Opendata, web and dolomites

LAF-GRAFT

An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LAF-GRAFT project word cloud

Explore the words cloud of the LAF-GRAFT project. It provides you a very rough idea of what is the project "LAF-GRAFT" about.

repertoire    technique    segments    capacity    cellular    tevgs    career    investigation    implanting    patent    evolve    graft    expand    render    engineered    tevg    hold    vorp    regulatory    culture    setting    surgeons    cardiovascular    manipulated    complementary    clinicians    phd    function    levels    appropriate    aspirate    laf    royal    scaling    cell    isolation    me    incorporating    burden    pittsburgh    act    efficient    vivo    college    fellowship    consolidate    promise    interposition    oject    skills    outgoing    ireland    lab    unviable    clinical    fluid    revolutionise    mechanical    characterisation    true    manipulation    brien    prof    regenerative    regarding    decrease    disease    vascular    morphological    medicine    treat    possess    tissue    cells    model    small    promotes    independent    digestion    viability    pr    return    david    liposuction    professional    scaffold    animal    date    bypass    biodegradable    onto    size    university    minimally    diseased    learned    stability    safer    untested    grafts    source    human    treatment    fergal    environment   

Project "LAF-GRAFT" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 248˙063 €
 EC max contribution 248˙063 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 248˙063.00
2    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00

Map

 Project objective

Tissue engineered vascular grafts (TEVGs) hold great promise in the field of regenerative medicine and also possess the true potential to revolutionise the way in which clinicians treat the growing burden of cardiovascular disease. Treatment is achieved by incorporating an appropriate cell source onto a biodegradable scaffold and implanting the graft to bypass non-patent vascular segments. However, numerous issues regarding TEVG cell source render the technique unviable in a clinical setting as the cells require high levels of manipulation including digestion, isolation and culture. These issues increase processing costs, decrease cell stability and raise numerous regulatory issues. The use of minimally manipulated liposuction aspirate fluid (LAF) may offer a safer and more efficient cellular source in regenerative TEVGs. However, the capacity of LAF to act as a viable cell source for TEVGs is untested. The aim of this pr oject is to determine the capacity of LAF derived cells to act as a viable cell source for TEVGs. This will be achieved through characterisation of the LAF cells, investigation of the environment that best promotes favourable cellular behaviour, an in vivo study on the viability of the graft to act as a vascular interposition in a small animal model, scaling of the graft to appropriate human size and finally an in vivo study of the grafts ability to function as a vascular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to expand my existing repertoire of research and complementary skills to consolidate and build upon what I have learned to date as I evolve my independent, professional research career.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LAF-GRAFT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LAF-GRAFT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

Mel.Photo.Protect (2019)

Unraveling the Photoprotecting Mechanism of Melanin - From a Library of Fragments to Simulation of Spectra and Function

Read More