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LAF-GRAFT

An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LAF-GRAFT project word cloud

Explore the words cloud of the LAF-GRAFT project. It provides you a very rough idea of what is the project "LAF-GRAFT" about.

fergal    vorp    clinicians    minimally    return    graft    fellowship    complementary    promise    isolation    incorporating    university    burden    expand    appropriate    setting    professional    segments    treat    decrease    pittsburgh    outgoing    laf    disease    david    tissue    revolutionise    medicine    ireland    act    evolve    date    fluid    model    culture    capacity    cardiovascular    independent    animal    regarding    efficient    morphological    untested    scaffold    render    skills    patent    viability    grafts    function    implanting    technique    royal    aspirate    manipulation    oject    hold    cell    source    regenerative    brien    career    pr    small    investigation    size    engineered    scaling    tevgs    onto    levels    promotes    digestion    prof    vivo    college    clinical    cellular    interposition    characterisation    biodegradable    tevg    consolidate    unviable    mechanical    repertoire    stability    safer    liposuction    possess    true    human    vascular    surgeons    diseased    learned    bypass    me    environment    cells    lab    regulatory    manipulated    phd    treatment   

Project "LAF-GRAFT" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND    more Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	248˙063 €
EC max contribution	248˙063 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2016
Duration (year-month-day)	from 2016-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND × ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a. Close	IE (DUBLIN)	coordinator	248˙063.00
2	UNIVERSITY OF PITTSBURGH × UNIVERSITY OF PITTSBURGH Organization address address: University Place 123 city: PITTSBURGH postcode: 15213 website: www.pitt.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a. Close	US (PITTSBURGH)	partner	0.00

Map

 Project objective

Tissue engineered vascular grafts (TEVGs) hold great promise in the field of regenerative medicine and also possess the true potential to revolutionise the way in which clinicians treat the growing burden of cardiovascular disease. Treatment is achieved by incorporating an appropriate cell source onto a biodegradable scaffold and implanting the graft to bypass non-patent vascular segments. However, numerous issues regarding TEVG cell source render the technique unviable in a clinical setting as the cells require high levels of manipulation including digestion, isolation and culture. These issues increase processing costs, decrease cell stability and raise numerous regulatory issues. The use of minimally manipulated liposuction aspirate fluid (LAF) may offer a safer and more efficient cellular source in regenerative TEVGs. However, the capacity of LAF to act as a viable cell source for TEVGs is untested. The aim of this pr oject is to determine the capacity of LAF derived cells to act as a viable cell source for TEVGs. This will be achieved through characterisation of the LAF cells, investigation of the environment that best promotes favourable cellular behaviour, an in vivo study on the viability of the graft to act as a vascular interposition in a small animal model, scaling of the graft to appropriate human size and finally an in vivo study of the grafts ability to function as a vascular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to expand my existing repertoire of research and complementary skills to consolidate and build upon what I have learned to date as I evolve my independent, professional research career.

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