An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts
Total Cost €
0
EC-Contrib. €
0
Partnership
0
Views
0
LAF-GRAFT project word cloud
Explore the words cloud of the LAF-GRAFT project. It provides you a very rough idea of what is the project "LAF-GRAFT" about.
Tissue engineered vascular grafts (TEVGs) hold great promise in the field of regenerative medicine and also possess the true potential to revolutionise the way in which clinicians treat the growing burden of cardiovascular disease. Treatment is achieved by incorporating an appropriate cell source onto a biodegradable scaffold and implanting the graft to bypass non-patent vascular segments. However, numerous issues regarding TEVG cell source render the technique unviable in a clinical setting as the cells require high levels of manipulation including digestion, isolation and culture. These issues increase processing costs, decrease cell stability and raise numerous regulatory issues. The use of minimally manipulated liposuction aspirate fluid (LAF) may offer a safer and more efficient cellular source in regenerative TEVGs. However, the capacity of LAF to act as a viable cell source for TEVGs is untested. The aim of this pr oject is to determine the capacity of LAF derived cells to act as a viable cell source for TEVGs. This will be achieved through characterisation of the LAF cells, investigation of the environment that best promotes favourable cellular behaviour, an in vivo study on the viability of the graft to act as a vascular interposition in a small animal model, scaling of the graft to appropriate human size and finally an in vivo study of the grafts ability to function as a vascular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to expand my existing repertoire of research and complementary skills to consolidate and build upon what I have learned to date as I evolve my independent, professional research career.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LAF-GRAFT" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "LAF-GRAFT" are provided by the European Opendata Portal: CORDIS opendata.
More projects from the same programme (H2020-EU.1.3.2.)
DiMaS (2019)
Retrospective genomic analyses of shortfin Mako shark (Isurus oxyrinchus) using DNA from archived jaws
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:8: parser error : Specification mandates value for attribute defer in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): <script defer src="//europa.eu/webtools/load.js" type="text/javascript"></scri in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:8: parser error : attributes construct error in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): <script defer src="//europa.eu/webtools/load.js" type="text/javascript"></scri in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:8: parser error : Couldn't find end of Start Tag script line 8 in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): <script defer src="//europa.eu/webtools/load.js" type="text/javascript"></scri in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:8: parser error : Opening and ending tag mismatch: meta line 6 and script in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): <script defer src="//europa.eu/webtools/load.js" type="text/javascript"></script in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:9: parser error : Opening and ending tag mismatch: link line 6 and noscript in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ><noscript><link rel="stylesheet" href="styles.9d673bcf1fc678af.css"></noscript> in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:9: parser error : Opening and ending tag mismatch: noscript line 6 and head in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ript><link rel="stylesheet" href="styles.9d673bcf1fc678af.css"></noscript></head in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:60: parser error : Specification mandates value for attribute defer in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): b0dcb.js" type="module"></script><script src="scripts.ea5372c71b6a43a6.js" defer in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:62: parser error : Opening and ending tag mismatch: link line 6 and html in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): </body></html><!-- random-length HTML comment: buHlEKtT25LDQ5NtvvfRHVi78y177yiYi in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): http://cordis.europa.eu/project/rcn/226994_en.xml:62: parser error : EndTag: '</' not found in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): 10Eg3lx9fYsle2itFDyi9dRg9cUPRJcIAen1Ga0jxiKRYq8crwArPSNNufa9o2HoUueaJU861GNP --> in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
Warning: simplexml_load_file(): ^ in /var/www/vhosts/fabiodisconzi.com/httpdocs/open-eu/h2020/show-project.php on line 1287
No valid XML