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LAF-GRAFT

An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LAF-GRAFT project word cloud

Explore the words cloud of the LAF-GRAFT project. It provides you a very rough idea of what is the project "LAF-GRAFT" about.

cardiovascular    isolation    ireland    human    interposition    manipulated    fergal    decrease    oject    regulatory    diseased    untested    burden    fluid    manipulation    repertoire    source    date    minimally    characterisation    render    independent    function    treatment    appropriate    mechanical    lab    aspirate    laf    grafts    regenerative    professional    consolidate    brien    viability    digestion    learned    segments    environment    scaffold    culture    model    college    clinicians    skills    morphological    royal    stability    cell    safer    complementary    size    possess    medicine    hold    return    revolutionise    engineered    vascular    onto    prof    true    cells    promise    efficient    regarding    clinical    disease    liposuction    scaling    fellowship    capacity    animal    act    tevg    treat    outgoing    graft    bypass    implanting    me    surgeons    unviable    technique    vivo    career    setting    promotes    david    patent    pr    biodegradable    evolve    levels    tissue    expand    investigation    phd    incorporating    pittsburgh    tevgs    university    small    cellular    vorp   

Project "LAF-GRAFT" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 248˙063 €
 EC max contribution 248˙063 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 248˙063.00
2    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00

Map

 Project objective

Tissue engineered vascular grafts (TEVGs) hold great promise in the field of regenerative medicine and also possess the true potential to revolutionise the way in which clinicians treat the growing burden of cardiovascular disease. Treatment is achieved by incorporating an appropriate cell source onto a biodegradable scaffold and implanting the graft to bypass non-patent vascular segments. However, numerous issues regarding TEVG cell source render the technique unviable in a clinical setting as the cells require high levels of manipulation including digestion, isolation and culture. These issues increase processing costs, decrease cell stability and raise numerous regulatory issues. The use of minimally manipulated liposuction aspirate fluid (LAF) may offer a safer and more efficient cellular source in regenerative TEVGs. However, the capacity of LAF to act as a viable cell source for TEVGs is untested. The aim of this pr oject is to determine the capacity of LAF derived cells to act as a viable cell source for TEVGs. This will be achieved through characterisation of the LAF cells, investigation of the environment that best promotes favourable cellular behaviour, an in vivo study on the viability of the graft to act as a vascular interposition in a small animal model, scaling of the graft to appropriate human size and finally an in vivo study of the grafts ability to function as a vascular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to expand my existing repertoire of research and complementary skills to consolidate and build upon what I have learned to date as I evolve my independent, professional research career.

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The information about "LAF-GRAFT" are provided by the European Opendata Portal: CORDIS opendata.

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