Opendata, web and dolomites

LAF-GRAFT

An Investigation into the viability of employing lipoaspirate fluid as a cellular source in the production of small diameter tissue engineered vascular grafts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LAF-GRAFT project word cloud

Explore the words cloud of the LAF-GRAFT project. It provides you a very rough idea of what is the project "LAF-GRAFT" about.

isolation    animal    cellular    possess    stability    ireland    liposuction    function    prof    segments    biodegradable    skills    manipulated    patent    implanting    minimally    capacity    digestion    appropriate    morphological    scaling    decrease    setting    grafts    viability    medicine    david    hold    untested    college    mechanical    treat    characterisation    graft    clinical    clinicians    tevg    efficient    human    professional    university    fellowship    laf    promise    brien    pittsburgh    model    independent    complementary    burden    learned    unviable    pr    return    manipulation    tevgs    cells    diseased    true    fergal    vascular    promotes    environment    me    source    cell    expand    investigation    bypass    fluid    safer    culture    interposition    revolutionise    outgoing    tissue    phd    disease    repertoire    evolve    vivo    regenerative    render    treatment    vorp    consolidate    cardiovascular    onto    oject    career    regarding    incorporating    size    small    scaffold    regulatory    surgeons    technique    lab    levels    engineered    date    aspirate    royal    act   

Project "LAF-GRAFT" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 248˙063 €
 EC max contribution 248˙063 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 248˙063.00
2    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00

Map

 Project objective

Tissue engineered vascular grafts (TEVGs) hold great promise in the field of regenerative medicine and also possess the true potential to revolutionise the way in which clinicians treat the growing burden of cardiovascular disease. Treatment is achieved by incorporating an appropriate cell source onto a biodegradable scaffold and implanting the graft to bypass non-patent vascular segments. However, numerous issues regarding TEVG cell source render the technique unviable in a clinical setting as the cells require high levels of manipulation including digestion, isolation and culture. These issues increase processing costs, decrease cell stability and raise numerous regulatory issues. The use of minimally manipulated liposuction aspirate fluid (LAF) may offer a safer and more efficient cellular source in regenerative TEVGs. However, the capacity of LAF to act as a viable cell source for TEVGs is untested. The aim of this pr oject is to determine the capacity of LAF derived cells to act as a viable cell source for TEVGs. This will be achieved through characterisation of the LAF cells, investigation of the environment that best promotes favourable cellular behaviour, an in vivo study on the viability of the graft to act as a vascular interposition in a small animal model, scaling of the graft to appropriate human size and finally an in vivo study of the grafts ability to function as a vascular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to expand my existing repertoire of research and complementary skills to consolidate and build upon what I have learned to date as I evolve my independent, professional research career.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LAF-GRAFT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LAF-GRAFT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

E-CLIPS (2019)

Effects of Cross-Linguistic Interactions on Perception of Speech

Read More  

Topo-circuit (2019)

Exploring topological phenomenon in RF circuits

Read More