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HumanPlacenta SIGNED

Human Placental Development and the Uterine Microenvironment

Total Cost €

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EC-Contrib. €

0

Partnership

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 HumanPlacenta project word cloud

Explore the words cloud of the HumanPlacenta project. It provides you a very rough idea of what is the project "HumanPlacenta" about.

placental    decidua    culture    arteries    glands    maternal    crispr    genome    influenced    reproductive    human    ethical    tissue    normal    how    extra    scaffolds    3d    earliest    transform    stages    regulating    infiltrate    specify    successful    mechanisms    limitations    signalling    central    organ    spiral    collagen    molecular    genomics    miscarriage    microenvironment    made    vitro    drawn    eclampsia    balance    vessel    single    immune    territorial    models    organoids    wall    organoid    uterine    underlying    conductance    environment    cell    embryonic    evt    capitalises    editing    cellular    paracrine    dangerous    tools    physiology    fetal    fetus    cas9    practical    invasion    model    cultures    combined    faithfully    restriction    remarkable    remodelling    cells    stromal    arterial    seeded    deficient    mucosa    boundary    trophoblast    stillbirth    excessive    decidual    placenta    artificial    pregnancy    ranging    trophectoderm    dilated    lineage    placentation    glandular    invade    lack    extravillous    depends    interactions    potentially    engineering    questions   

Project "HumanPlacenta" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙992˙098 €
 EC max contribution 1˙992˙098 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙992˙098.00

Map

 Project objective

How does the human placenta develop and how is this influenced by the maternal uterine microenvironment? These are the central questions addressed in my proposal. Normal growth and development of the fetus depends on the placenta, the extra-embryonic organ derived from trophectoderm. Successful pregnancy depends on the earliest stages of development when placental extravillous trophoblast cells (EVT) infiltrate the uterine mucosa, the decidua. EVT invade the decidua to transform the uterine spiral arteries into a dilated vessel capable of high conductance. Deficient arterial remodelling by EVT results in miscarriage, pre-eclampsia, fetal growth restriction and stillbirth. However, excessive invasion into the uterine wall is also potentially dangerous. Thus, to achieve a successful pregnancy, a territorial boundary is drawn with a balance between fetal EVT invasion and maternal decidual cells. Understanding the molecular and cellular mechanisms underlying these maternal/fetal interactions has been challenging due both to practical and ethical limitations and lack of reliable in vitro models. I have recently derived 3D culture systems (organoids) from human decidua and placenta that will provide the essential tools. I will use these organoids combined with single cell genomics, Crispr/Cas9 genome editing and tissue engineering to study: (i) the molecular mechanisms that specify the EVT lineage (ii) the role of paracrine signalling from maternal decidual glands in regulating placental development (iii) cell-cell interactions between decidua and EVT by creating an artificial model of decidua made from tailored collagen scaffolds seeded with stromal, glandular and immune cells. My proposal capitalises on the remarkable ability of organoid cultures to faithfully model human physiology. The human uterine environment in early pregnancy is crucial for reproductive success and development of an in vitro model of placentation will have a wide-ranging impact.

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The information about "HUMANPLACENTA" are provided by the European Opendata Portal: CORDIS opendata.

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