Opendata, web and dolomites

HumanPlacenta SIGNED

Human Placental Development and the Uterine Microenvironment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HumanPlacenta project word cloud

Explore the words cloud of the HumanPlacenta project. It provides you a very rough idea of what is the project "HumanPlacenta" about.

deficient    combined    drawn    dangerous    paracrine    evt    mucosa    fetus    transform    regulating    ethical    placenta    scaffolds    placentation    normal    cas9    physiology    stromal    central    influenced    earliest    trophectoderm    cells    interactions    how    models    wall    crispr    invasion    glandular    immune    infiltrate    culture    stillbirth    arteries    questions    lineage    practical    human    faithfully    cultures    excessive    depends    signalling    organ    genome    pregnancy    mechanisms    vitro    environment    lack    placental    extra    3d    microenvironment    potentially    eclampsia    organoids    territorial    editing    remodelling    capitalises    dilated    cell    trophoblast    seeded    stages    arterial    engineering    decidua    remarkable    conductance    genomics    fetal    maternal    single    glands    specify    invade    extravillous    miscarriage    reproductive    cellular    boundary    limitations    molecular    restriction    artificial    model    collagen    balance    embryonic    organoid    decidual    underlying    uterine    tissue    ranging    successful    tools    spiral    vessel    made   

Project "HumanPlacenta" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙992˙098 €
 EC max contribution 1˙992˙098 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙992˙098.00

Map

 Project objective

How does the human placenta develop and how is this influenced by the maternal uterine microenvironment? These are the central questions addressed in my proposal. Normal growth and development of the fetus depends on the placenta, the extra-embryonic organ derived from trophectoderm. Successful pregnancy depends on the earliest stages of development when placental extravillous trophoblast cells (EVT) infiltrate the uterine mucosa, the decidua. EVT invade the decidua to transform the uterine spiral arteries into a dilated vessel capable of high conductance. Deficient arterial remodelling by EVT results in miscarriage, pre-eclampsia, fetal growth restriction and stillbirth. However, excessive invasion into the uterine wall is also potentially dangerous. Thus, to achieve a successful pregnancy, a territorial boundary is drawn with a balance between fetal EVT invasion and maternal decidual cells. Understanding the molecular and cellular mechanisms underlying these maternal/fetal interactions has been challenging due both to practical and ethical limitations and lack of reliable in vitro models. I have recently derived 3D culture systems (organoids) from human decidua and placenta that will provide the essential tools. I will use these organoids combined with single cell genomics, Crispr/Cas9 genome editing and tissue engineering to study: (i) the molecular mechanisms that specify the EVT lineage (ii) the role of paracrine signalling from maternal decidual glands in regulating placental development (iii) cell-cell interactions between decidua and EVT by creating an artificial model of decidua made from tailored collagen scaffolds seeded with stromal, glandular and immune cells. My proposal capitalises on the remarkable ability of organoid cultures to faithfully model human physiology. The human uterine environment in early pregnancy is crucial for reproductive success and development of an in vitro model of placentation will have a wide-ranging impact.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HUMANPLACENTA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HUMANPLACENTA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RESOURCE Q (2019)

Efficient Conversion of Quantum Information Resources

Read More  

CohoSing (2019)

Cohomology and Singularities

Read More  

EXTREME (2020)

The Epistemology and Ethics of Fundamentalism

Read More