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HumanPlacenta SIGNED

Human Placental Development and the Uterine Microenvironment

Total Cost €

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EC-Contrib. €

0

Partnership

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 HumanPlacenta project word cloud

Explore the words cloud of the HumanPlacenta project. It provides you a very rough idea of what is the project "HumanPlacenta" about.

trophectoderm    evt    placentation    fetal    glands    balance    miscarriage    limitations    cas9    extra    central    cultures    restriction    stages    underlying    culture    earliest    infiltrate    combined    wall    engineering    placenta    spiral    mechanisms    arterial    dilated    genomics    ranging    successful    cellular    conductance    placental    stromal    environment    vessel    organoid    depends    how    single    tissue    organ    lineage    excessive    immune    influenced    potentially    invasion    faithfully    3d    pregnancy    boundary    dangerous    invade    models    drawn    uterine    reproductive    arteries    regulating    vitro    decidua    fetus    model    decidual    mucosa    genome    normal    cells    specify    ethical    extravillous    cell    editing    capitalises    collagen    made    remarkable    maternal    paracrine    embryonic    territorial    signalling    crispr    transform    interactions    microenvironment    questions    physiology    seeded    organoids    eclampsia    lack    tools    remodelling    molecular    human    stillbirth    scaffolds    practical    deficient    artificial    trophoblast    glandular   

Project "HumanPlacenta" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙992˙098 €
 EC max contribution 1˙992˙098 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙992˙098.00

Map

 Project objective

How does the human placenta develop and how is this influenced by the maternal uterine microenvironment? These are the central questions addressed in my proposal. Normal growth and development of the fetus depends on the placenta, the extra-embryonic organ derived from trophectoderm. Successful pregnancy depends on the earliest stages of development when placental extravillous trophoblast cells (EVT) infiltrate the uterine mucosa, the decidua. EVT invade the decidua to transform the uterine spiral arteries into a dilated vessel capable of high conductance. Deficient arterial remodelling by EVT results in miscarriage, pre-eclampsia, fetal growth restriction and stillbirth. However, excessive invasion into the uterine wall is also potentially dangerous. Thus, to achieve a successful pregnancy, a territorial boundary is drawn with a balance between fetal EVT invasion and maternal decidual cells. Understanding the molecular and cellular mechanisms underlying these maternal/fetal interactions has been challenging due both to practical and ethical limitations and lack of reliable in vitro models. I have recently derived 3D culture systems (organoids) from human decidua and placenta that will provide the essential tools. I will use these organoids combined with single cell genomics, Crispr/Cas9 genome editing and tissue engineering to study: (i) the molecular mechanisms that specify the EVT lineage (ii) the role of paracrine signalling from maternal decidual glands in regulating placental development (iii) cell-cell interactions between decidua and EVT by creating an artificial model of decidua made from tailored collagen scaffolds seeded with stromal, glandular and immune cells. My proposal capitalises on the remarkable ability of organoid cultures to faithfully model human physiology. The human uterine environment in early pregnancy is crucial for reproductive success and development of an in vitro model of placentation will have a wide-ranging impact.

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The information about "HUMANPLACENTA" are provided by the European Opendata Portal: CORDIS opendata.

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