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HumanPlacenta SIGNED

Human Placental Development and the Uterine Microenvironment

Total Cost €

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EC-Contrib. €

0

Partnership

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 HumanPlacenta project word cloud

Explore the words cloud of the HumanPlacenta project. It provides you a very rough idea of what is the project "HumanPlacenta" about.

depends    combined    engineering    restriction    placenta    crispr    pregnancy    signalling    interactions    immune    territorial    organoids    miscarriage    dilated    genome    specify    trophectoderm    eclampsia    3d    lack    underlying    remarkable    arteries    arterial    tools    fetal    made    physiology    lineage    scaffolds    trophoblast    potentially    glandular    stillbirth    invasion    human    vessel    ranging    capitalises    models    cells    transform    evt    deficient    cultures    single    model    earliest    faithfully    reproductive    ethical    collagen    artificial    questions    culture    cas9    drawn    placental    cell    microenvironment    mucosa    how    limitations    editing    decidual    successful    extra    decidua    infiltrate    mechanisms    organoid    genomics    maternal    uterine    tissue    fetus    excessive    balance    wall    regulating    cellular    central    glands    spiral    stages    remodelling    organ    stromal    placentation    paracrine    embryonic    normal    vitro    seeded    dangerous    conductance    boundary    molecular    extravillous    influenced    practical    invade    environment   

Project "HumanPlacenta" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙992˙098 €
 EC max contribution 1˙992˙098 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙992˙098.00

Map

 Project objective

How does the human placenta develop and how is this influenced by the maternal uterine microenvironment? These are the central questions addressed in my proposal. Normal growth and development of the fetus depends on the placenta, the extra-embryonic organ derived from trophectoderm. Successful pregnancy depends on the earliest stages of development when placental extravillous trophoblast cells (EVT) infiltrate the uterine mucosa, the decidua. EVT invade the decidua to transform the uterine spiral arteries into a dilated vessel capable of high conductance. Deficient arterial remodelling by EVT results in miscarriage, pre-eclampsia, fetal growth restriction and stillbirth. However, excessive invasion into the uterine wall is also potentially dangerous. Thus, to achieve a successful pregnancy, a territorial boundary is drawn with a balance between fetal EVT invasion and maternal decidual cells. Understanding the molecular and cellular mechanisms underlying these maternal/fetal interactions has been challenging due both to practical and ethical limitations and lack of reliable in vitro models. I have recently derived 3D culture systems (organoids) from human decidua and placenta that will provide the essential tools. I will use these organoids combined with single cell genomics, Crispr/Cas9 genome editing and tissue engineering to study: (i) the molecular mechanisms that specify the EVT lineage (ii) the role of paracrine signalling from maternal decidual glands in regulating placental development (iii) cell-cell interactions between decidua and EVT by creating an artificial model of decidua made from tailored collagen scaffolds seeded with stromal, glandular and immune cells. My proposal capitalises on the remarkable ability of organoid cultures to faithfully model human physiology. The human uterine environment in early pregnancy is crucial for reproductive success and development of an in vitro model of placentation will have a wide-ranging impact.

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The information about "HUMANPLACENTA" are provided by the European Opendata Portal: CORDIS opendata.

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