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ExpoBiome SIGNED

Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

Total Cost €

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EC-Contrib. €

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Partnership

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 ExpoBiome project word cloud

Explore the words cloud of the ExpoBiome project. It provides you a very rough idea of what is the project "ExpoBiome" about.

chronic    effector    machine    ecosystem    immune    neurodegenerative    fasting    learning    inflammation    intervention    model    interactions    eluded    acids    pd    disease    newly    limiting    samples    contributes    prior    systematic    signature    functional    clinical    expobiome    individuals    perform    mechanistic    parkinson    treatment    predict    comprehensively    gap    chip    validate    quantitative    time    anti    map    relationships    humix    constituents    outcomes    levels    integrate    health    diseases    track    nucleic    elucidation    physiology    human    molecules    causal    diagnosed    comprising    omic    rheumatoid    insights    ra    basis    screened    host    molecular    collected    microbial    contextualised    therapeutic    unknown    genes    healthy    combination    compounds    microbiome    inflammatory    microbes    biomarker    proteins    diagnostic    arthritis    functions    models    data    patients    personalised    autoimmune    base    characterised    generate    metabolites    immunophenotypes    resolution    gut    poly    first    peptides   

Project "ExpoBiome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DU LUXEMBOURG 

Organization address
address: 2 AVENUE DE L'UNIVERSITE
city: ESCH-SUR-ALZETTE
postcode: 4365
website: http://wwwen.uni.lu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Luxembourg [LU]
 Total cost 1˙998˙620 €
 EC max contribution 1˙998˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) coordinator 1˙998˙620.00

Map

 Project objective

The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.

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The information about "EXPOBIOME" are provided by the European Opendata Portal: CORDIS opendata.

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