Opendata, web and dolomites

ExpoBiome SIGNED

Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ExpoBiome project word cloud

Explore the words cloud of the ExpoBiome project. It provides you a very rough idea of what is the project "ExpoBiome" about.

pd    humix    poly    mechanistic    predict    microbes    basis    quantitative    resolution    levels    limiting    generate    proteins    molecular    gap    biomarker    chip    interactions    effector    machine    time    molecules    parkinson    inflammation    screened    elucidation    contextualised    insights    model    eluded    learning    therapeutic    clinical    anti    map    diseases    physiology    relationships    chronic    comprehensively    outcomes    host    human    immunophenotypes    newly    microbiome    diagnostic    prior    microbial    fasting    integrate    metabolites    compounds    patients    inflammatory    individuals    omic    validate    rheumatoid    ecosystem    unknown    treatment    data    nucleic    disease    gut    autoimmune    signature    neurodegenerative    diagnosed    constituents    comprising    personalised    collected    healthy    acids    combination    samples    peptides    expobiome    base    health    functions    causal    first    intervention    systematic    characterised    ra    genes    arthritis    perform    models    functional    track    immune    contributes   

Project "ExpoBiome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DU LUXEMBOURG 

Organization address
address: 2 AVENUE DE L'UNIVERSITE
city: ESCH-SUR-ALZETTE
postcode: 4365
website: http://wwwen.uni.lu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Luxembourg [LU]
 Total cost 1˙998˙620 €
 EC max contribution 1˙998˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) coordinator 1˙998˙620.00

Map

 Project objective

The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EXPOBIOME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EXPOBIOME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

E-DURA (2018)

Commercialization of novel soft neural interfaces

Read More