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ExpoBiome SIGNED

Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

Total Cost €

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EC-Contrib. €

0

Partnership

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 ExpoBiome project word cloud

Explore the words cloud of the ExpoBiome project. It provides you a very rough idea of what is the project "ExpoBiome" about.

elucidation    proteins    newly    health    neurodegenerative    biomarker    host    eluded    peptides    autoimmune    integrate    chronic    immune    diagnostic    pd    ecosystem    functions    patients    insights    inflammation    validate    rheumatoid    effector    metabolites    healthy    fasting    treatment    track    screened    individuals    causal    intervention    relationships    personalised    omic    physiology    outcomes    chip    combination    immunophenotypes    comprehensively    learning    limiting    quantitative    humix    base    perform    genes    interactions    model    acids    levels    basis    predict    human    compounds    microbial    generate    comprising    unknown    data    microbiome    samples    diagnosed    ra    time    therapeutic    disease    gut    inflammatory    prior    nucleic    map    contributes    parkinson    gap    characterised    molecules    anti    clinical    poly    functional    diseases    models    first    arthritis    constituents    signature    expobiome    contextualised    collected    microbes    machine    resolution    systematic    molecular    mechanistic   

Project "ExpoBiome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DU LUXEMBOURG 

Organization address
address: 2 AVENUE DE L'UNIVERSITE
city: ESCH-SUR-ALZETTE
postcode: 4365
website: http://wwwen.uni.lu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Luxembourg [LU]
 Total cost 1˙998˙620 €
 EC max contribution 1˙998˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) coordinator 1˙998˙620.00

Map

 Project objective

The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.

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The information about "EXPOBIOME" are provided by the European Opendata Portal: CORDIS opendata.

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