Opendata, web and dolomites

ExpoBiome SIGNED

Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ExpoBiome project word cloud

Explore the words cloud of the ExpoBiome project. It provides you a very rough idea of what is the project "ExpoBiome" about.

model    personalised    poly    comprehensively    combination    perform    levels    immunophenotypes    autoimmune    acids    diseases    patients    individuals    gap    parkinson    basis    expobiome    interactions    arthritis    microbes    molecules    functional    validate    gut    ra    track    quantitative    contextualised    healthy    newly    elucidation    systematic    comprising    human    metabolites    effector    integrate    diagnosed    learning    microbial    anti    collected    constituents    functions    machine    rheumatoid    health    generate    neurodegenerative    time    samples    first    base    genes    characterised    therapeutic    diagnostic    contributes    unknown    map    inflammation    proteins    eluded    predict    molecular    compounds    peptides    fasting    limiting    intervention    data    resolution    microbiome    humix    omic    screened    chip    pd    insights    causal    treatment    physiology    signature    mechanistic    host    relationships    models    inflammatory    clinical    outcomes    nucleic    biomarker    prior    chronic    disease    immune    ecosystem   

Project "ExpoBiome" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DU LUXEMBOURG 

Organization address
address: 2 AVENUE DE L'UNIVERSITE
city: ESCH-SUR-ALZETTE
postcode: 4365
website: http://wwwen.uni.lu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Luxembourg [LU]
 Total cost 1˙998˙620 €
 EC max contribution 1˙998˙620 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-05-01   to  2025-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) coordinator 1˙998˙620.00

Map

 Project objective

The human gut microbiome is a complex ecosystem, which contributes essential functions to human physiology. Changes to the microbiome are associated with several chronic diseases characterised by inflammation, including neurodegenerative and autoimmune diseases. Microbiome-derived effector molecules comprising nucleic acids, (poly)peptides and metabolites are present at high levels in the gut but have so far eluded systematic study. This gap in knowledge is limiting mechanistic understanding of the microbiome’s functional impact on chronic diseases such as Parkinson’s disease (PD) and rheumatoid arthritis (RA). Here, I will for the first time integrate a combination of advanced high-resolution methodologies to comprehensively identify the constituents of this molecular complex and their impact on the human immune system. First, I will perform a quantitative, integrated multi-omic analysis on microbiome samples collected from healthy individuals and patients with newly diagnosed PD or RA. I will integrate and analyse the data using a newly developed knowledge base. Using contextualised prior knowledge (ExpoBiome Map) and machine learning methods, I will identify microbial molecules associated with condition-specific immunophenotypes. Second, I will validate and track the biomarker signature during a model clinical intervention (therapeutic fasting) to predict treatment outcomes. Third, microbes and molecules will be screened in personalised HuMiX gut-on-chip models to identify novel anti-inflammatory compounds. By providing mechanistic insights into the molecular basis of human-microbiome interactions, the project will generate essential new knowledge about causal relationships between the gut microbiome and the immune system in health and disease. By facilitating the elucidation of currently unknown microbiome-derived molecules, it will identify new genes, proteins, metabolites and host pathways for the development of future diagnostic and therapeutic applications.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EXPOBIOME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EXPOBIOME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

TRUST (2018)

Truth and Semantics

Read More