Opendata, web and dolomites

TRANSLATIONAL SIGNED

A new translational strategy for tailored treatment of type 2 diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TRANSLATIONAL project word cloud

Explore the words cloud of the TRANSLATIONAL project. It provides you a very rough idea of what is the project "TRANSLATIONAL" about.

cells    progression    strategies    intervention    devastating    archetypes    disease    variability    understand    resistance    attempted    patient    type    pathophysiological    underlying    metabolic    characterised    fashion    preservation    enormous    methodology    proportions    unable    pathophysiology    expression    guidelines    secretory    mechanistic    central    pointing    secretion    error    sulforaphane    training    extends    clusters    leads    ultimately    relevance    conduct    complications    dedifferentiate    unusual    prevent    combined    bioinformatics    influenced    point    previously    patients    physiology    firmly    pronounced    divided    whilst    gut    functional    stop    drugs    severe    health    insights    prevention    t2d    builds    clinical    diabetes    poor    demonstration    escalating    respectively    proposition    disciplinary    microbiota    questions    ideally    cell    expand    trial    found    compounds    gene    causes    treatment    emphasise    diabetic    personalized    medicine    insulin    starting    anti   

Project "TRANSLATIONAL" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙957˙230 €
 EC max contribution 1˙957˙230 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2025-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 1˙957˙230.00

Map

 Project objective

Type 2 diabetes (T2D) is an escalating health problem of enormous proportions. Current treatment strategies are unable to stop disease progression and prevent the devastating complications. Clinical guidelines emphasise the need for personalized treatment. However, this is currently implemented on trial-and-error fashion. We have recently found that T2D patients can be divided into four clusters, each with different characteristics. This represents a major step forward by pointing out the high variability of the pathophysiology and leads us to propose that anti-diabetic treatment should ideally target the underlying pathophysiology of each patient. The overall goal is to test this proposition by targeting existing and new treatment to patients who are archetypes of the two most severe T2D clusters, characterised by poor insulin secretion and pronounced insulin resistance, respectively. As a starting point, we will study how treatment response to existing drugs is influenced by pathophysiological features and also the gut microbiota. Next, we will expand on our recent demonstration that b-cells dedifferentiate in T2D and define the functional and gene expression changes that cause secretory failure. These mechanistic insights will be used to identify new targets for b-cell preservation, which is essential to stop disease progression, in particular in patients with poor secretion. Finally, we will study new compounds for tailored treatment, including sulforaphane as an early intervention for those with severe insulin resistance. My combined training in cell-physiology, bioinformatics and clinical medicine is unusual but necessary to conduct this multi-disciplinary programme. Whilst the programme builds firmly on my past research, it extends far beyond what I have attempted previously by exploiting novel state-of-the-art methodology to address central metabolic questions of high relevance to understand the causes, management and – ultimately – prevention of diabetes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRANSLATIONAL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRANSLATIONAL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More