Explore the words cloud of the PHOTO-CYCLE project. It provides you a very rough idea of what is the project "PHOTO-CYCLE" about.
The following table provides information about the project.
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
|Coordinator Country||Spain [ES]|
|Total cost||160˙932 €|
|EC max contribution||160˙932 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2020-03-01 to 2022-02-28|
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|1||FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA||ES (TARRAGONA)||coordinator||160˙932.00|
We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection of optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. PHOTO-CYCLE seeks to provide some solutions by developing effective technology to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Specifically, we will use photochemical organocatalytic cascade processes to synthesise polycyclic lactones and polyfunctionalized cyclohexanols, which are common motifs in biologically active molecules. We will combine asymmetric organocatalysis and photochemistry, two powerful strategies of modern chemical research. They have extraordinary potential for the sustainable preparation of novel organic molecules, which are needed to drive innovation in the pharmaceutical industry. PHOTO-CYCLE aims to combine the fellow’s experience in allene chemistry and organocatalysis and the host’s experience in photo-triggered asymmetric processes to develop otherwise unachievable catalytic asymmetric cascade reactions. Specifically, we will focus on the rich reactivity of excited chiral iminium ions to activate readily available allenes and trigger cascade processes. The resulting strategies will be used as an ideal platform for assembling libraries comprising chiral polycyclic lactones and cyclohexanols, which, along with biological screening carried out in collaboration with Lundbeck A/S, will increase the probability of success in identifying drug-candidate structures. The multi-cultural and intersectorial nature of this project will greatly contribute to broaden the fellow’s competencies and will place him in a competitive position for the next career move.
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The information about "PHOTO-CYCLE" are provided by the European Opendata Portal: CORDIS opendata.