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SinFonia SIGNED

Synthetic biology-guided engineering of Pseudomonas putida for biofluorination

Total Cost €

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EC-Contrib. €

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Partnership

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SinFonia project word cloud

Explore the words cloud of the SinFonia project. It provides you a very rough idea of what is the project "SinFonia" about.

generating source biofluorinations naf versatile fouling dependent compounds polyesters pseudomonas engineering natural point nature energy fluoropolymers smart membranes substrates corrosive environment toxic harsh carbon components halogen self earth designing extremely resistance coatings environmental communication biofluorination agents pathogenic fluorinated cleaning sugars interactive fluorine cells alternative biochemical unfulfilled containing uses surfaces exclusively inexpensive economic salt fluorinating platform fuel organic microbial view execute chemical bacterial market metabolically materials ideal proposes safe physicochemical serves kt2440 coupled synthesize lubricants benefits material technologies strain family bioproduction engineer bioprocesses sought added safer renewable hardly surface soil enhanced strains fluorochemicals synthesized industrial negative usually abundant involve reagents sinfonia anti fluorination bio social putida unlike engineered sustainable stressful bacterium extraordinary easily reactions worldwide

Project "SinFonia" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	7˙948˙503 €
EC max contribution	7˙948˙503 € (100%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2018-two-stage
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	1˙811˙921.00
2	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	1˙010˙875.00
3	BIOPLASTECH LTD BIOPLASTECH LTD Organization address address: CASHEL ROAD UNIT 9 BLOCK C CASHEL BUSINESS CENTRE city: DUBLIN postcode: 12 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	715˙103.00
4	UNIVERSITE DU LUXEMBOURG UNIVERSITE DU LUXEMBOURG Organization address address: 2 AVENUE DE L'UNIVERSITE city: ESCH-SUR-ALZETTE postcode: 4365 website: http://wwwen.uni.lu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (ESCH-SUR-ALZETTE)	participant	631˙590.00
5	CHEMOURS NETHERLANDS BV CHEMOURS NETHERLANDS BV Organization address address: BAANHOEKWEG 22 city: Dordrecht postcode: 3313 LA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Dordrecht)	participant	595˙000.00
6	THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Organization address address: NORTH STREET 66 COLLEGE GATE city: ST ANDREWS postcode: KY16 9AJ website: www.st-andrews.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ST ANDREWS)	participant	481˙250.00
7	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	443˙965.00
8	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	435˙287.00
9	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	390˙000.00
10	IN SRL IN SRL Organization address address: VIA CARDUCCI 9A city: UDINE postcode: 33100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (UDINE)	participant	382˙682.00
11	BIOFACTION KG BIOFACTION KG Organization address address: KUNDMANNGASSE 39/12 city: WIEN postcode: 1030 website: www.biofaction.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	375˙268.00
12	IFEU - INSTITUT FUR ENERGIE UND UMWELTFORSCHUNG HEIDELBERG GMBH IFEU - INSTITUT FUR ENERGIE UND UMWELTFORSCHUNG HEIDELBERG GMBH Organization address address: IM WEIHER 10 city: HEIDELBERG postcode: 69121 website: www.ifeu.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	373˙000.00
13	ALTAR ALTAR Organization address address: 5 RUE HENRI DESBRUERES BIO CLUSTER GENOPOLE CAMPUS 1 city: EVRY postcode: 91030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (EVRY)	participant	302˙560.00

Map

Project objective

Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic benefits of the new fluorination technology, and interactive communication of social benefits associated with target products, are essential components of SinFonia.

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