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SinFonia SIGNED

Synthetic biology-guided engineering of Pseudomonas putida for biofluorination

Total Cost €

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EC-Contrib. €

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Partnership

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 SinFonia project word cloud

Explore the words cloud of the SinFonia project. It provides you a very rough idea of what is the project "SinFonia" about.

worldwide    uses    compounds    polyesters    economic    resistance    engineering    fluorination    biofluorinations    fluorinating    market    added    self    salt    usually    toxic    halogen    unfulfilled    cleaning    surfaces    bacterium    interactive    synthesize    safer    platform    source    extremely    sustainable    bio    versatile    pseudomonas    designing    serves    harsh    fluoropolymers    communication    fluorine    point    sought    components    smart    containing    sinfonia    technologies    benefits    microbial    strains    bacterial    organic    sugars    cells    bioprocesses    industrial    involve    negative    fluorinated    environment    dependent    materials    social    stressful    engineer    enhanced    execute    abundant    agents    earth    alternative    hardly    fouling    reactions    easily    synthesized    physicochemical    substrates    family    soil    putida    proposes    extraordinary    engineered    chemical    biofluorination    strain    kt2440    energy    biochemical    corrosive    coatings    fluorochemicals    lubricants    membranes    reagents    environmental    nature    coupled    inexpensive    safe    carbon    material    anti    unlike    surface    natural    fuel    pathogenic    naf    view    exclusively    renewable    metabolically    bioproduction    ideal    generating   

Project "SinFonia" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 7˙948˙503 €
 EC max contribution 7˙948˙503 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙811˙921.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙010˙875.00
3    BIOPLASTECH LTD IE (DUBLIN) participant 715˙103.00
4    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 631˙590.00
5    CHEMOURS NETHERLANDS BV NL (Dordrecht) participant 595˙000.00
6    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 481˙250.00
7    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 443˙965.00
8    Masarykova univerzita CZ (BRNO STRED) participant 435˙287.00
9    TARTU ULIKOOL EE (TARTU) participant 390˙000.00
10    IN SRL IT (UDINE) participant 382˙682.00
11    BIOFACTION KG AT (WIEN) participant 375˙268.00
12    IFEU - INSTITUT FUR ENERGIE UND UMWELTFORSCHUNG HEIDELBERG GMBH DE (HEIDELBERG) participant 373˙000.00
13    ALTAR FR (EVRY) participant 302˙560.00

Map

 Project objective

Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic benefits of the new fluorination technology, and interactive communication of social benefits associated with target products, are essential components of SinFonia.

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The information about "SINFONIA" are provided by the European Opendata Portal: CORDIS opendata.

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