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SinFonia SIGNED

Synthetic biology-guided engineering of Pseudomonas putida for biofluorination

Total Cost €

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EC-Contrib. €

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Partnership

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 SinFonia project word cloud

Explore the words cloud of the SinFonia project. It provides you a very rough idea of what is the project "SinFonia" about.

pseudomonas    family    environment    involve    fluoropolymers    source    easily    reagents    serves    materials    engineered    sought    earth    bioprocesses    hardly    ideal    salt    safer    abundant    uses    biofluorination    polyesters    compounds    biochemical    safe    versatile    renewable    added    worldwide    engineering    sugars    environmental    view    natural    fluorinated    technologies    cells    membranes    enhanced    extremely    exclusively    coatings    metabolically    bacterial    components    stressful    carbon    smart    unlike    nature    usually    lubricants    fuel    fluorochemicals    halogen    soil    strain    sinfonia    harsh    cleaning    synthesized    putida    microbial    bioproduction    social    agents    proposes    interactive    dependent    biofluorinations    organic    fluorinating    strains    economic    execute    anti    chemical    corrosive    surfaces    industrial    kt2440    coupled    bacterium    communication    extraordinary    synthesize    platform    fluorine    benefits    fouling    toxic    physicochemical    pathogenic    engineer    alternative    bio    designing    energy    generating    naf    substrates    sustainable    containing    reactions    material    unfulfilled    market    self    negative    point    fluorination    surface    inexpensive    resistance   

Project "SinFonia" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 7˙948˙503 €
 EC max contribution 7˙948˙503 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙811˙921.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙010˙875.00
3    BIOPLASTECH LTD IE (DUBLIN) participant 715˙103.00
4    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 631˙590.00
5    CHEMOURS NETHERLANDS BV NL (Dordrecht) participant 595˙000.00
6    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 481˙250.00
7    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 443˙965.00
8    Masarykova univerzita CZ (BRNO STRED) participant 435˙287.00
9    TARTU ULIKOOL EE (TARTU) participant 390˙000.00
10    IN SRL IT (UDINE) participant 382˙682.00
11    BIOFACTION KG AT (WIEN) participant 375˙268.00
12    IFEU - INSTITUT FUR ENERGIE UND UMWELTFORSCHUNG HEIDELBERG GMBH DE (HEIDELBERG) participant 373˙000.00
13    ALTAR FR (EVRY) participant 302˙560.00

Map

 Project objective

Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic benefits of the new fluorination technology, and interactive communication of social benefits associated with target products, are essential components of SinFonia.

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The information about "SINFONIA" are provided by the European Opendata Portal: CORDIS opendata.

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