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SinFonia SIGNED

Synthetic biology-guided engineering of Pseudomonas putida for biofluorination

Total Cost €

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EC-Contrib. €

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Partnership

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 SinFonia project word cloud

Explore the words cloud of the SinFonia project. It provides you a very rough idea of what is the project "SinFonia" about.

exclusively    biofluorinations    fluoropolymers    social    biofluorination    technologies    synthesize    engineered    material    point    designing    fuel    worldwide    putida    strain    toxic    surfaces    safe    dependent    interactive    negative    ideal    chemical    view    surface    fluorinating    alternative    engineering    environmental    engineer    anti    membranes    polyesters    substrates    stressful    pseudomonas    components    cleaning    sought    proposes    strains    easily    sinfonia    harsh    kt2440    energy    added    abundant    usually    bioprocesses    soil    inexpensive    safer    fluorine    sugars    communication    extremely    family    renewable    halogen    agents    source    self    industrial    nature    hardly    platform    bacterium    generating    fluorination    containing    microbial    bioproduction    sustainable    uses    salt    fouling    fluorochemicals    unlike    extraordinary    naf    reactions    lubricants    environment    bacterial    organic    market    synthesized    smart    coupled    benefits    metabolically    coatings    serves    pathogenic    enhanced    economic    compounds    resistance    natural    corrosive    earth    physicochemical    reagents    unfulfilled    execute    fluorinated    biochemical    bio    involve    cells    versatile    carbon    materials   

Project "SinFonia" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 7˙948˙503 €
 EC max contribution 7˙948˙503 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙811˙921.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙010˙875.00
3    BIOPLASTECH LTD IE (DUBLIN) participant 715˙103.00
4    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 631˙590.00
5    CHEMOURS NETHERLANDS BV NL (Dordrecht) participant 595˙000.00
6    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 481˙250.00
7    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 443˙965.00
8    Masarykova univerzita CZ (BRNO STRED) participant 435˙287.00
9    TARTU ULIKOOL EE (TARTU) participant 390˙000.00
10    IN SRL IT (UDINE) participant 382˙682.00
11    BIOFACTION KG AT (WIEN) participant 375˙268.00
12    IFEU - INSTITUT FUR ENERGIE UND UMWELTFORSCHUNG HEIDELBERG GMBH DE (HEIDELBERG) participant 373˙000.00
13    ALTAR FR (EVRY) participant 302˙560.00

Map

 Project objective

Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic benefits of the new fluorination technology, and interactive communication of social benefits associated with target products, are essential components of SinFonia.

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The information about "SINFONIA" are provided by the European Opendata Portal: CORDIS opendata.

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