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SinFonia SIGNED

Synthetic biology-guided engineering of Pseudomonas putida for biofluorination

Total Cost €

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EC-Contrib. €

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Partnership

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 SinFonia project word cloud

Explore the words cloud of the SinFonia project. It provides you a very rough idea of what is the project "SinFonia" about.

fouling    microbial    unfulfilled    biofluorination    fluoropolymers    self    reactions    natural    putida    engineer    resistance    sought    coatings    compounds    bioproduction    smart    fluorine    naf    designing    anti    communication    agents    fuel    cells    sugars    technologies    renewable    polyesters    physicochemical    bio    biofluorinations    fluorination    biochemical    carbon    soil    worldwide    stressful    uses    components    harsh    reagents    industrial    exclusively    nature    salt    bacterial    synthesized    involve    extraordinary    pathogenic    sustainable    serves    safer    extremely    market    kt2440    engineering    generating    easily    cleaning    engineered    material    proposes    synthesize    surface    negative    added    dependent    toxic    family    materials    unlike    fluorinated    benefits    surfaces    fluorinating    inexpensive    bacterium    containing    substrates    economic    lubricants    view    earth    pseudomonas    organic    abundant    enhanced    strain    interactive    bioprocesses    alternative    coupled    fluorochemicals    environmental    social    energy    versatile    usually    sinfonia    membranes    point    chemical    platform    safe    source    corrosive    execute    halogen    environment    ideal    strains    metabolically    hardly   

Project "SinFonia" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 7˙948˙503 €
 EC max contribution 7˙948˙503 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙811˙921.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙010˙875.00
3    BIOPLASTECH LTD IE (DUBLIN) participant 715˙103.00
4    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 631˙590.00
5    CHEMOURS NETHERLANDS BV NL (Dordrecht) participant 595˙000.00
6    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) participant 481˙250.00
7    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 443˙965.00
8    Masarykova univerzita CZ (BRNO STRED) participant 435˙287.00
9    TARTU ULIKOOL EE (TARTU) participant 390˙000.00
10    IN SRL IT (UDINE) participant 382˙682.00
11    BIOFACTION KG AT (WIEN) participant 375˙268.00
12    IFEU - INSTITUT FUR ENERGIE UND UMWELTFORSCHUNG HEIDELBERG GMBH DE (HEIDELBERG) participant 373˙000.00
13    ALTAR FR (EVRY) participant 302˙560.00

Map

 Project objective

Nature has hardly evolved biochemical reactions involving fluorine (F), the most abundant halogen on Earth. Organic compounds containing F (fluorochemicals) are, however, extremely relevant from an industrial point of view. Fluoropolymers are the main fluorochemicals in the market worldwide, and are exclusively synthesized using chemical methods. Moreover, current fluorination technologies usually involve corrosive and toxic reagents that have a negative impact on the environment. Designing sustainable bioprocesses based on alternative and safer fluorinating agents from renewable substrates is thus a long-sought-after, yet unfulfilled goal. SinFonia proposes to engineer the metabolically-versatile bacterium Pseudomonas putida to execute biofluorinations for generating novel fluoropolymers from renewable substrates. P. putida KT2440, a non-pathogenic soil bacterium, serves as an ideal microbial platform for F-dependent biochemical reactions due to its extraordinary resistance to harsh and stressful operating conditions. SinFonia will exploit natural selection to enhance bioproduction through a smart strain engineering approach in which bacterial growth will be coupled to biofluorination. Our target compounds are a whole family of fluorinated polyesters with enhanced physicochemical and material properties, with uses as self-cleaning surfaces, low-surface-energy coatings, bio-based lubricants, membranes for fuel cells, and anti-fouling materials. The versatile P. putida strains engineered during the project can be easily adapted to synthesize other added-value fluorochemicals. Unlike chemical processes, the source of F in our system will be NaF, an inexpensive and safe salt, and sugars as the main carbon source. In-depth analysis of all the environmental and economic benefits of the new fluorination technology, and interactive communication of social benefits associated with target products, are essential components of SinFonia.

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The information about "SINFONIA" are provided by the European Opendata Portal: CORDIS opendata.

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