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Turbo-MPMI-Discovery SIGNED

TurboID-charging discovery of plant pathogen virulence and host resistance mechanisms

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Turbo-MPMI-Discovery project word cloud

Explore the words cloud of the Turbo-MPMI-Discovery project. It provides you a very rough idea of what is the project "Turbo-MPMI-Discovery" about.

albugo    allele    tagged    recognition    goals    training    me    break    plant    capacity    provides    effector    activate    tcp14    pl    intracellular    turboid    modified    dramatically    interactions    ms    pathogens    opportunity    mpmi    pairs    suppression    kingdoms    multidisciplinary    microbe    isolate    identification    active    protein    chilling    chs3    vicinity    candida    mobility    manipulate    temperatures    international    proteins    leadership    employability    broad    discovery    professional    canada    proximity    ccg    biotin    benefit    sensitive    interactor    immune    boost    host    detect    transcription    transferrable    accelerate    taxonomic    receptors    ambient    advantage    interacting    shed    alongside    visibility    pathogen    msca    receptor    skills    confer    bioid    molecular    bottleneck    effectors    cells    labelling    oomycete    inject    uk    arabidopsis    undertaking    tsl    virulence    china    light    extensive   

Project "Turbo-MPMI-Discovery" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 212˙933.00

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 Project objective

'Extensive studies in the field of Molecular Plant-Microbe Interactions (MPMI) show that pathogens inject virulence factors ('effectors') into host cells to manipulate host proteins and promote pathogen success. Recognition of effectors or their modified host proteins by plant intracellular receptors can activate immune responses. Identification of effector-host interactor (host target and intracellular receptor) pairs remains challenging. A more sensitive and specific approach to define effector-host interactor pairs would greatly accelerate discovery in plant-microbe interactions. Proximity labelling (PL) with biotin ('BioID') provides a novel method to detect proteins in the vicinity of a tagged protein. Taking advantage of the recently developed ('TurboID') allele that is highly active at ambient plant temperatures, the main goals of this project are to: 1) establish a sensitive and specific method (TurboID-based PL-MS) to identify effector-host interactor pairs; 2) use this method to identify host targets of 6 CCG effectors of oomycete Albugo candida that confer immune suppression to Arabidopsis; 3) isolate host target transcription factor TCP14-interacting effectors from pathogens from three taxonomic kingdoms, and to identify intracellular receptors CHS3 (Chilling sensitive 3)-interacting effectors. The method proposed here will break the bottleneck of defining effector-host interactor pairs and dramatically accelerate discovery in plant-microbe interactions. The identification of CCG effector targets will shed light on the strong immune suppression capacity of A. candida. My MSCA is a great opportunity for me to build on my previous international mobility from China to Canada and now to the UK, by undertaking advanced multidisciplinary ‘training-through-research’ at TSL. I shall benefit from broad technical and transferrable skills training alongside many dissemination opportunities to boost my professional visibility, leadership capacity and employability.'

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