EU H2020 Project "TURBO-MPMI-DISCOVERY (TurboID-charging discovery of plant pathogen virulence and host resistance..)": description, partecipants, costs and EC-fundings

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Turbo-MPMI-Discovery project word cloud

Explore the words cloud of the Turbo-MPMI-Discovery project. It provides you a very rough idea of what is the project "Turbo-MPMI-Discovery" about.

identification labelling accelerate interacting shed skills china alongside modified pl activate tsl suppression vicinity receptors detect virulence molecular me professional immune allele pathogen confer intracellular effectors goals kingdoms mobility employability taxonomic ambient isolate active transcription microbe tcp14 plant bottleneck dramatically interactions ms arabidopsis training capacity break sensitive mpmi host msca undertaking broad visibility tagged protein biotin effector provides turboid pathogens uk proteins oomycete canada benefit manipulate chs3 opportunity transferrable chilling multidisciplinary ccg candida boost inject interactor extensive albugo receptor pairs light cells discovery recognition temperatures international bioid leadership proximity advantage

Project "Turbo-MPMI-Discovery" data sheet

The following table provides information about the project.

Coordinator	THE SAINSBURY LABORATORY Organization address address: Norwich Research Park, Colney Lane city: NORWICH postcode: NR47UH website: http://www.tsl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	212˙933 €
EC max contribution	212˙933 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-EF-ST
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2022-03-31

#	participants	country	role	EC contrib. [€]
1	THE SAINSBURY LABORATORY	UK (NORWICH)	coordinator	212˙933.00

THE SAINSBURY LABORATORY

UK (NORWICH)

coordinator

212˙933.00

Project objective

'Extensive studies in the field of Molecular Plant-Microbe Interactions (MPMI) show that pathogens inject virulence factors ('effectors') into host cells to manipulate host proteins and promote pathogen success. Recognition of effectors or their modified host proteins by plant intracellular receptors can activate immune responses. Identification of effector-host interactor (host target and intracellular receptor) pairs remains challenging. A more sensitive and specific approach to define effector-host interactor pairs would greatly accelerate discovery in plant-microbe interactions. Proximity labelling (PL) with biotin ('BioID') provides a novel method to detect proteins in the vicinity of a tagged protein. Taking advantage of the recently developed ('TurboID') allele that is highly active at ambient plant temperatures, the main goals of this project are to: 1) establish a sensitive and specific method (TurboID-based PL-MS) to identify effector-host interactor pairs; 2) use this method to identify host targets of 6 CCG effectors of oomycete Albugo candida that confer immune suppression to Arabidopsis; 3) isolate host target transcription factor TCP14-interacting effectors from pathogens from three taxonomic kingdoms, and to identify intracellular receptors CHS3 (Chilling sensitive 3)-interacting effectors. The method proposed here will break the bottleneck of defining effector-host interactor pairs and dramatically accelerate discovery in plant-microbe interactions. The identification of CCG effector targets will shed light on the strong immune suppression capacity of A. candida. My MSCA is a great opportunity for me to build on my previous international mobility from China to Canada and now to the UK, by undertaking advanced multidisciplinary ‘training-through-research’ at TSL. I shall benefit from broad technical and transferrable skills training alongside many dissemination opportunities to boost my professional visibility, leadership capacity and employability.'

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