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MELGEN SIGNED

MELanoma GENetics - understanding and biomarking the genetic and immunological determinants of melanoma survival

Total Cost €

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EC-Contrib. €

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 MELGEN project word cloud

Explore the words cloud of the MELGEN project. It provides you a very rough idea of what is the project "MELGEN" about.

tumour    immunogenic    progression    immunid    interoperable    eagle    education    clinical    controls    treat    datasets    tests    applicable    communications    interdisciplinary    biomarking    ultimate    survival    report    private    genomics    insufficient    genetics    servicexs    cancer    models    15    biomarkers    potentially    commercial    collaborative    determinants    esrs    immunological    statistics    digitronix    etn    environment    recruit    2012    public    underpin    made    inter    science    melanoma    drivers    medicine    predictive    innovative    foundation    digital    recommendations    personalised    bioinformatics    tools    professionals    drive    melanomas    core    sectorial    stage    host    recommended    melgen    industry    frameworks    provision    considerable    accessible    genetic    precision    generation    therapy    leaders    translational    suppress    network    training    immunology    decision    prognostic    progress    immunity    cancers    applies    biotech    create    genomic   

Project "MELGEN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.melgen.org
 Total cost 3˙988˙365 €
 EC max contribution 3˙988˙365 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 819˙863.00
2    LUNDS UNIVERSITET SE (LUND) participant 790˙977.00
3    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 747˙649.00
4    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 572˙550.00
5    GENOME RESEARCH LIMITED UK (LONDON) participant 546˙575.00
6    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 510˙748.00

Map

 Project objective

MELGEN (MELanoma GENetics) – understanding and biomarking the genetic and immunological determinants of melanoma survival

The MELGEN European Training Network (ETN) will create an environment for long-term, collaborative, inter-sectorial cancer genetics research with the ultimate aim of improving precision (personalised) medicine. In a 2012 report the European Science Foundation identified the importance of precision medicine and recommended that there should be 1) provision of comprehensive, accessible and interoperable datasets 2) improved models and decision-making processes, 3) interdisciplinary, public-private partnerships and translational research, and 4) dedicated funding including access to core technology and frameworks for education and training of professionals. This application addresses all four recommendations and applies them to melanoma. Considerable, but insufficient, progress has been made in understanding the genetic changes within melanomas that drive tumour progression, and how those drivers can be targeted to treat melanoma. Melanoma is also an especially immunogenic cancer and much more needs to be understood of how melanomas suppress host immunological responses. Understanding what controls immunity in melanoma will be potentially applicable to other cancers. Finally, we need prognostic and predictive biomarkers for selection of precision therapy. This ETN will recruit 15 early stage researchers (ESRs) to address these issues. It will bring together leaders in clinical research, genomics, statistics, bioinformatics, and the biotech industry to exploit the new genomic tools and tumour immunology. MELGEN’s commercial partners are developing immunological tests (ImmunID), bioinformatics (Eagle Genomics), commercial genomics (ServiceXS) and digital design/communications (Digitronix) and they will underpin an innovative, interdisciplinary training programme for the next generation of melanoma researchers.

 Deliverables

List of deliverables.
D7.1 Documents, reports 2019-04-30 15:37:08
D6.2 Other 2019-04-30 15:37:08
D6.1 Other 2019-04-30 15:37:08

Take a look to the deliverables list in detail:  detailed list of MELGEN deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Shamik Mitra, Martin Lauss, Rita Cabrita, Jiyeon Choi, Tongwu Zhang, Karolin Isaksson, Håkan Olsson, Christian Ingvar, Ana Carneiro, Johan Staaf, Markus Ringnér, Kari Nielsen, Kevin M. Brown, Göran Jönsson
Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma
published pages: , ISSN: 1574-7891, DOI: 10.1002/1878-0261.12663
Molecular Oncology 2020-03-13
2017 Rahul Metri, Abhilash Mohan, Jérémie Nsengimana, Joanna Pozniak, Carmen Molina-Paris, Julia Newton-Bishop, David Bishop, Nagasuma Chandra
Identification of a gene signature for discriminating metastatic from primary melanoma using a molecular interaction network approach
published pages: 17314, ISSN: 2045-2322, DOI: 10.1038/s41598-017-17330-0
Scientific Reports 7/1 2020-03-05
2018 Sabrina A. Hogan, Mitchell P. Levesque, Phil F. Cheng
Melanoma Immunotherapy: Next-Generation Biomarkers
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2018.00178
Frontiers in Oncology 8 2020-03-05
2020 Metzenmacher, Váraljai, Hegedüs, Cima, Forster, Schramm, Scheffler, Horn, Klein, Szarvas, Reis, Bielefeld, Roesch, Aigner, Kunzmann, Wiesweg, Siveke, Schuler, Lueong
Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer
published pages: 353, ISSN: 2072-6694, DOI: 10.3390/cancers12020353
Cancers 12/2 2020-03-05
2019 Marina Juraleviciute, Joanna Pozniak, Jérémie Nsengimana, Mark Harland, Juliette Randerson‐Moor, Patrik Wernhoff, Assia Bassarova, Geir Frode Øy, Gunhild Trøen, Vivi Ann Flørenes, David Timothy Bishop, Meenhard Herlyn, Julia Newton‐Bishop, Ana Slipicevic
MX 2 is a novel regulator of cell cycle in melanoma cells
published pages: , ISSN: 1755-1471, DOI: 10.1111/pcmr.12837
Pigment Cell & Melanoma Research 2020-03-05
2019 Rohit Thakur, Jonathan P. Laye, Martin Lauss, Joey Mark S. Diaz, Sally Jane O\'Shea, Joanna Poźniak, Anastasia Filia, Mark Harland, Joanne Gascoyne, Juliette A. Randerson-Moor, May Chan, Tracey Mell, Göran Jönsson, D. Timothy Bishop, Julia Newton-Bishop, Jennifer H. Barrett, Jérémie Nsengimana
Transcriptomic Analysis Reveals Prognostic Molecular Signatures of Stage I Melanoma
published pages: 7424-7435, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-18-3659
Clinical Cancer Research 25/24 2020-03-05
2019 Anastasia Filia, Alastair Droop, Mark Harland, Helene Thygesen, Juliette Randerson-Moor, Helen Snowden, Claire Taylor, Joey Mark S. Diaz, Joanna Pozniak, Jérémie Nsengimana, Jon Laye, Julia A. Newton-Bishop, D. Timothy Bishop
High-Resolution Copy Number Patterns From Clinically Relevant FFPE Material
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45210-2
Scientific Reports 9/1 2020-03-05
2017 Reinhard Dummer, Egle Ramelyte, Sabrina Schindler, Olaf Thürigen, Mitchell P. Levesque, Peter Koelblinger
MEK inhibition and immune responses in advanced melanoma
published pages: e1335843, ISSN: 2162-402X, DOI: 10.1080/2162402X.2017.1335843
OncoImmunology 6/8 2020-03-05
2019 Sabrina A. Hogan, Anaïs Courtier, Phil F. Cheng, Nicoletta F. Jaberg-Bentele, Simone M. Goldinger, Manuarii Manuel, Solène Perez, Nadia Plantier, Jean-François Mouret, Thi Dan Linh Nguyen-Kim, Marieke I.G. Raaijmakers, Pia Kvistborg, Nicolas Pasqual, John B.A.G. Haanen, Reinhard Dummer, Mitchell P. Levesque
Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma
published pages: 77-85, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-18-0136
Cancer Immunology Research 7/1 2020-03-05
2019 Joanna Poźniak, Jérémie Nsengimana, Jonathan P. Laye, Sally J. O’Shea, Joey Mark S. Diaz, Alastair P. Droop, Anastasia Filia, Mark Harland, John R. Davies, Tracey Mell, Juliette A. Randerson-Moor, Sathya Muralidhar, Sabrina A. Hogan, Sandra Nicole Freiberger, Mitchell P. Levesque, Graham P. Cook, D. Timothy Bishop, Julia Newton-Bishop
Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
published pages: 2684-2696, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-2864
Cancer Research 79/10 2020-03-05
2019 Sathya Muralidhar, Anastasia Filia, Jérémie Nsengimana, Joanna Poźniak, Sally J. O\'Shea, Joey M. Diaz, Mark Harland, Juliette A. Randerson-Moor, Jörg Reichrath, Jonathan P. Laye, Louise van der Weyden, David J. Adams, D.T. Bishop, Julia Newton-Bishop
Vitamin D–VDR Signaling Inhibits Wnt/β-Catenin–Mediated Melanoma Progression and Promotes Antitumor Immunity
published pages: 5986-5998, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-3927
Cancer Research 79/23 2020-03-05
2018 Jérémie Nsengimana, Jon Laye, Anastasia Filia, Sally O’Shea, Sathya Muralidhar, Joanna Poźniak, Alastair Droop, May Chan, Christy Walker, Louise Parkinson, Joanne Gascoyne, Tracey Mell, Minttu Polso, Rosalyn Jewell, Juliette Randerson-Moor, Graham P. Cook, D. Timothy Bishop, Julia Newton-Bishop
β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas
published pages: 2048-2063, ISSN: 0021-9738, DOI: 10.1172/JCI95351
Journal of Clinical Investigation 128/5 2020-03-05
2019 Bengt Phung, Maciej Cieśla, Adriana Sanna, Nicola Guzzi, Giulia Beneventi, Phuong Cao Thi Ngoc, Martin Lauss, Rita Cabrita, Eugenia Cordero, Ana Bosch, Frida Rosengren, Jari Häkkinen, Klaus Griewank, Annette Paschen, Katja Harbst, Håkan Olsson, Christian Ingvar, Ana Carneiro, Hensin Tsao, Dirk Schadendorf, Kristian Pietras, Cristian Bellodi, Göran Jönsson
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma
published pages: 3573-3586.e7, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.05.069
Cell Reports 27/12 2020-03-05
2019 Renáta Váraljai, Kilian Wistuba-Hamprecht, Teofila Seremet, Joey Mark S. Diaz, Jérémie Nsengimana, Antje Sucker, Klaus Griewank, Jan-Malte Placke, Peter A. Horn, Nils von Neuhoff, Batool Shannan, Heike Chauvistré, Felix C. E. Vogel, Susanne Horn, Jürgen C. Becker, Julia Newton-Bishop, Andreas Stang, Bart Neyns, Benjamin Weide, Dirk Schadendorf, Alexander Roesch
Application of Circulating Cell-Free Tumor DNA Profiles for Therapeutic Monitoring and Outcome Prediction in Genetically Heterogeneous Metastatic Melanoma
published pages: 1-10, ISSN: 2473-4284, DOI: 10.1200/po.18.00229
JCO Precision Oncology 3 2020-03-05
2018 R. Varaljai, N. Neuhoff, A. Sucker, J. Newton‐Bishop, D. Schadendorf, A. Roesch
45th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) Zurich, Switzerland, March 7-10, 2018
published pages: e2-e106, ISSN: 0906-6705, DOI: 10.1111/exd.13486
Experimental Dermatology 27/3 2020-03-05
2019 E. Christodoulou, M. Visser, T. P. Potjer, N. van der Stoep, M. Rodríguez-Girondo, R. van Doorn, N. Gruis
Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers
published pages: 439-444, ISSN: 1389-9600, DOI: 10.1007/s10689-019-00137-5
Familial Cancer 18/4 2020-03-05
2018 S Leonardelli, S Horn, A Sucker, D Schadendorf, K Griewank, A Paschen
PO-399 Tumour CDKN2A loss predisposes to immunotherapy resistance
published pages: A386.1-A386, ISSN: , DOI: 10.1136/esmoopen-2018-eacr25.911
Genomic Alterations in Cancer 3 (Suppl 2) 2020-03-05
2019 Catarina Salgado, Eliza Mari Kwesi-Maliepaard, Aart G. Jochemsen, Mijke Visser, Mark Harland, Fred van Leeuwen, Remco van Doorn, Nelleke Gruis
A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma
published pages: 582-589, ISSN: 0960-8931, DOI: 10.1097/cmr.0000000000000640
Melanoma Research 29/6 2020-03-05
2020 Eirini Christodoulou, Remco van Doorn, Mijke Visser, Amina Teunisse, Mieke Versluis, Pieter van der Velden, Nicholas K Hayward, Aart Jochemsen, Nelleke Gruis
NEK11 as a candidate high-penetrance melanoma susceptibility gene
published pages: 203-210, ISSN: 0022-2593, DOI: 10.1136/jmedgenet-2019-106134
Journal of Medical Genetics 57/3 2020-03-05
2020 Rita Cabrita, Martin Lauss, Adriana Sanna, Marco Donia, Mathilde Skaarup Larsen, Shamik Mitra, Iva Johansson, Bengt Phung, Katja Harbst, Johan Vallon-Christersson, Alison van Schoiack, Kristina Lövgren, Sarah Warren, Karin Jirström, Håkan Olsson, Kristian Pietras, Christian Ingvar, Karolin Isaksson, Dirk Schadendorf, Henrik Schmidt, Lars Bastholt, Ana Carneiro, Jennifer A. Wargo, Inge Marie Sva
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
published pages: 561-565, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1914-8
Nature 577/7791 2020-03-05
2018 Sofia Y. Chen, Rashid Mamunur, Jon Laye, D. Timothy Bishop, Julia A. Newton-Bishop, David J. Adams
Abstract 5372: The mutational landscape of primary cutaneous melanoma
published pages: 5372-5372, ISSN: , DOI: 10.1158/1538-7445.am2018-5372
Molecular and Cellular Biology / Genetics 78(13 Suppl) 2020-03-05
2019 Adriana Sanna, Katja Harbst, Iva Johansson, Gustav Christensen, Martin Lauss, Shamik Mitra, Frida Rosengren, Jari Häkkinen, Johan Vallon‐Christersson, Håkan Olsson, Åsa Ingvar, Karolin Isaksson, Christian Ingvar, Kari Nielsen, Göran Jönsson
Tumor genetic heterogeneity analysis of chronic sun‐damaged melanoma
published pages: , ISSN: 1755-1471, DOI: 10.1111/pcmr.12851
Pigment Cell & Melanoma Research 2020-03-05
2018 Carsten Krieg, Malgorzata Nowicka, Silvia Guglietta, Sabrina Schindler, Felix J Hartmann, Lukas M Weber, Reinhard Dummer, Mark D Robinson, Mitchell P Levesque, Burkhard Becher
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
published pages: 144-153, ISSN: 1078-8956, DOI: 10.1038/nm.4466
Nature Medicine 24/2 2020-03-05
2019 Lazaro Hiram Betancourt, Krzysztof Pawłowski, Jonatan Eriksson, A. Marcell Szasz, Shamik Mitra, Indira Pla, Charlotte Welinder, Henrik Ekedahl, Per Broberg, Roger Appelqvist, Maria Yakovleva, Yutaka Sugihara, Kenichi Miharada, Christian Ingvar, Lotta Lundgren, Bo Baldetorp, Håkan Olsson, Melinda Rezeli, Elisabet Wieslander, Peter Horvatovich, Johan Malm, Göran Jönsson, György Marko-Varga
Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41625-z
Scientific Reports 9/1 2020-03-05
2017 Martin Lauss, Marco Donia, Katja Harbst, Rikke Andersen, Shamik Mitra, Frida Rosengren, Maryem Salim, Johan Vallon-Christersson, Therese Törngren, Anders Kvist, Markus Ringnér, Inge Marie Svane, Göran Jönsson
Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
published pages: 1738, ISSN: 2041-1723, DOI: 10.1038/s41467-017-01460-0
Nature Communications 8/1 2020-03-05
2019 Renata Varaljai, Kilian Wistuba-Hamprecht, Teofila Seremet, Joey Mark Santiago Diaz, Jeremie Nsengimana, Antje Sucker, Klaus Griewank, Peter Horn, Nils von Neuhoff, Batool Shannan, Heike Chauvistré, Felix Christian Eduard Vogel, Susanne Horn, Jürgen C. Becker, Julia Newton-Bishop, Andreas Stang, Bart Neyns, Benjamin Weide, Dirk Schadendorf, Alexander Roesch
ctDNA as a noninvasive monitoring tool in metastatic melanoma.
published pages: 9548-9548, ISSN: 0732-183X, DOI: 10.1200/jco.2019.37.15_suppl.9548
Journal of Clinical Oncology 37/15_suppl 2020-03-05
2018 Multiple abstracts from multiple ESRs: Joanna Pozniak, Sathya Muralidhar, Rohit Thakur, Joey Mark Diaz, Shamik Mitra, Adriana Sanna, Rita Cabrita, Sonia Leonardelli, Ishani Banik
SMR Congress 2018 Abstracts
published pages: 92-172, ISSN: 1755-1471, DOI: 10.1111/pcmr.12738
Pigment Cell & Melanoma Research 32/1 2020-03-05
2018 R Varaljai, N Von Neuhoff, A Sucker, J Newton-Bishop, D Schadendorf, A Roesch
PO-493 ctDNA profiles of metastatic melanoma patients under therapy
published pages: A423.1-A423, ISSN: , DOI: 10.1136/esmoopen-2018-eacr25.995
Poster Presentation: Translational Research 3 (Suppl 2) 2020-03-05
2018 Joanna Pozniak, Jeremie Nsengimana, Jon Laye, Sally O\'Shea, Sabrina Schindler, Mitch Levesque, Tim Bishop, Julia Newton-Bishop
Abstract 5204: MYC expression and smoking as drivers of failure of immune response to melanoma
published pages: 5204-5204, ISSN: , DOI: 10.1158/1538-7445.am2018-5204
Tumor Biology 78(13 Suppl) 2020-03-05
2020 Catarina Salgado, Jan Oosting, Bart Janssen, Rajiv Kumar, Nelleke Gruis, Remco Doorn
Genome‐wide characterization of 5‐hydoxymethylcytosine in melanoma reveals major differences with nevus
published pages: , ISSN: 1045-2257, DOI: 10.1002/gcc.22837
Genes, Chromosomes and Cancer 2020-03-05
2018 Sathya Muralidhar, Jeremie Nsengimana, Joanna Pozniak, Sally O\'Shea, Jonathan Laye, David Adams, Louise van der Weyden, Timothy Bishop, Julia Newton-Bishop
Abstract 5205: Primary melanoma expression of the vitamin D receptor ( VDR ) is protective for melanoma survival and is associated with increased tumor immune response, decreased Wnt/B-catenin signaling and tumor proliferation
published pages: 5205-5205, ISSN: , DOI: 10.1158/1538-7445.am2018-5205
Tumor Biology 78(13 Suppl) 2020-03-05
2016 Egle Ramelyte, Sabrina A. Schindler, Reinhard Dummer
The safety of anti PD-1 therapeutics for the treatment of melanoma
published pages: 41-53, ISSN: 1474-0338, DOI: 10.1080/14740338.2016.1248402
Expert Opinion on Drug Safety 16/1 2020-03-05
2018 Abstracts from ESRs: Marina Juraleviciute, Sabrina Schindler
SMR Congress 2017 abstracts
published pages: 125-230, ISSN: 1755-1471, DOI: 10.1111/pcmr.12656
Pigment Cell & Melanoma Research 31/1 2020-03-05
2017 Mykyta Artomov, Alexander J. Stratigos, Ivana Kim, Raj Kumar, Martin Lauss, Bobby Y. Reddy, Benchun Miao, Carla Daniela Robles-Espinoza, Aravind Sankar, Ching-Ni Njauw, Kristen Shannon, Evangelos S. Gragoudas, Anne Marie Lane, Vivek Iyer, Julia A. Newton-Bishop, D. Timothy Bishop, Elizabeth A. Holland, Graham J. Mann, Tarjinder Singh, Jeffrey Barrett, David J. Adams, Göran Jönsson, Mark J. Daly, Hensin Tsao
Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing
published pages: , ISSN: 0027-8874, DOI: 10.1093/jnci/djx083
JNCI: Journal of the National Cancer Institute 109/12 2019-05-27
2017 Simone L. Scholz, Inga Möller, Henning Reis, Daniela Süßkind, Johannes A. P. van de Nes, Sonia Leonardelli, Bastian Schilling, Elisabeth Livingstone, Tobias Schimming, Annette Paschen, Antje Sucker, Rajmohan Murali, Klaus-Peter Steuhl, Dirk Schadendorf, Henrike Westekemper, Klaus G. Griewank
Frequent GNAQ, GNA11 , and EIF1AX Mutations in Iris Melanoma
published pages: 3464, ISSN: 1552-5783, DOI: 10.1167/iovs.17-21838
Investigative Opthalmology & Visual Science 58/9 2019-05-27

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