Opendata, web and dolomites

ProArc SIGNED

The protein archive: preservation potential of ancient human diets and diseases.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProArc project word cloud

Explore the words cloud of the ProArc project. It provides you a very rough idea of what is the project "ProArc" about.

tissues    surfaces    shown    energy    energetics    minerals    ancient    environmental    world    frontier    tissue    dna    migration    biomolecules    gibbs    paleoecological    ceramics    retrieved    vitro    adsorption    decrease    quantitative    proarc    disease    idea    human    fossil    desorption    span    bulk    interacting    calculus    longevity    interactions    archaeological    composition    onto    solution    mineral    adsorbed    lipid    date    peptide    nature    history    associations    individuals    serve    fraction    gbu    africa    quantify    free    examine    organisms    eggshell    implying    bound    kinetic    bonds    significantly    environments    interaction    zooms    molecules    almost    decay    proteins    samples    sediments    routinely    model    persist    parts    tool    palaeogenetic    assessing    despite    ma    sequence    rate    microbial    qualitative    single    communities    preservative    delta    realization    sex    protein    preservation    bond    artefacts    conceptual    sequences    stability   

Project "ProArc" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

DNA and proteins are now almost routinely being retrieved from sediments and archaeological artefacts. Despite the realization that adsorption of DNA molecules onto the surfaces of minerals can significantly decrease the DNA and protein decay rate, the longevity of mineral bound biomolecules is a still-standing frontier. Recently it was shown that peptide sequences in eggshell proteins persist to 3.8 Ma in Africa, implying that protein sequences will span the whole of human history in all parts of the world. Ancient protein sequences, therefore, persist beyond the lipid or DNA sequence and can be used to identify organisms (ZooMS), identify specific tissues, sex individuals, and identify tissue responses to disease. Understanding the protein-mineral interaction and environmental preservative conditions of adsorbed biomolecules – proteins can thus allow us to a) target such environments for paleoecological and palaeogenetic studies and; b) serve as a quantitative tool for assessing protein sequence migration i.e. ancient microbial communities. To date, we only have a qualitative idea of how solution composition affects the protein-mineral adsorption/desorption at the bulk level, and we have no quantitative insight into the single bond level energetics as well as the nature and fraction of the interacting bonds. With ProArc I will: a) assess the proteins preservation state in archaeological samples like calculus and ceramics and other fossil samples. I will also: (b) quantify the Gibbs free energy (ΔGbu) and kinetic bond parameters of in vitro protein-mineral interactions; and (c) examine the nature, fraction and stability of interacting bonds of in vitro protein-mineral associations at the bulk level. (d) Finally, I will make a conceptual model for addressing the characteristics and longevity of different protein-mineral systems.

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The information about "PROARC" are provided by the European Opendata Portal: CORDIS opendata.

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