Opendata, web and dolomites

ProArc SIGNED

The protein archive: preservation potential of ancient human diets and diseases.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProArc project word cloud

Explore the words cloud of the ProArc project. It provides you a very rough idea of what is the project "ProArc" about.

decay    peptide    proarc    minerals    despite    africa    rate    model    interacting    energetics    bonds    ceramics    associations    biomolecules    quantify    proteins    span    molecules    interactions    bound    date    organisms    parts    qualitative    migration    artefacts    ma    human    delta    decrease    history    idea    adsorbed    gibbs    desorption    single    composition    adsorption    implying    dna    gbu    lipid    assessing    communities    surfaces    individuals    mineral    routinely    tissue    persist    paleoecological    longevity    onto    stability    conceptual    almost    preservation    nature    sediments    interaction    calculus    ancient    realization    bond    energy    fossil    zooms    protein    vitro    environmental    serve    world    preservative    sequences    free    palaeogenetic    disease    kinetic    retrieved    bulk    microbial    examine    sequence    eggshell    frontier    shown    sex    significantly    fraction    archaeological    samples    environments    tool    solution    tissues    quantitative   

Project "ProArc" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

DNA and proteins are now almost routinely being retrieved from sediments and archaeological artefacts. Despite the realization that adsorption of DNA molecules onto the surfaces of minerals can significantly decrease the DNA and protein decay rate, the longevity of mineral bound biomolecules is a still-standing frontier. Recently it was shown that peptide sequences in eggshell proteins persist to 3.8 Ma in Africa, implying that protein sequences will span the whole of human history in all parts of the world. Ancient protein sequences, therefore, persist beyond the lipid or DNA sequence and can be used to identify organisms (ZooMS), identify specific tissues, sex individuals, and identify tissue responses to disease. Understanding the protein-mineral interaction and environmental preservative conditions of adsorbed biomolecules – proteins can thus allow us to a) target such environments for paleoecological and palaeogenetic studies and; b) serve as a quantitative tool for assessing protein sequence migration i.e. ancient microbial communities. To date, we only have a qualitative idea of how solution composition affects the protein-mineral adsorption/desorption at the bulk level, and we have no quantitative insight into the single bond level energetics as well as the nature and fraction of the interacting bonds. With ProArc I will: a) assess the proteins preservation state in archaeological samples like calculus and ceramics and other fossil samples. I will also: (b) quantify the Gibbs free energy (ΔGbu) and kinetic bond parameters of in vitro protein-mineral interactions; and (c) examine the nature, fraction and stability of interacting bonds of in vitro protein-mineral associations at the bulk level. (d) Finally, I will make a conceptual model for addressing the characteristics and longevity of different protein-mineral systems.

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The information about "PROARC" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-12 6:55:10) correctly updated