Opendata, web and dolomites

ProArc SIGNED

The protein archive: preservation potential of ancient human diets and diseases.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProArc project word cloud

Explore the words cloud of the ProArc project. It provides you a very rough idea of what is the project "ProArc" about.

stability    artefacts    fossil    proteins    energy    protein    retrieved    migration    samples    desorption    tool    adsorbed    interactions    archaeological    examine    composition    organisms    associations    ceramics    paleoecological    frontier    delta    parts    ancient    bonds    decay    communities    africa    zooms    persist    longevity    sequences    mineral    microbial    proarc    molecules    sex    sequence    bound    interacting    kinetic    adsorption    idea    nature    almost    realization    onto    span    dna    tissue    model    vitro    surfaces    history    environmental    human    minerals    gbu    date    fraction    calculus    disease    lipid    tissues    shown    individuals    single    assessing    free    qualitative    interaction    biomolecules    quantitative    ma    despite    significantly    palaeogenetic    environments    world    gibbs    peptide    decrease    eggshell    sediments    serve    implying    quantify    preservative    bulk    rate    routinely    bond    preservation    solution    conceptual    energetics   

Project "ProArc" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

DNA and proteins are now almost routinely being retrieved from sediments and archaeological artefacts. Despite the realization that adsorption of DNA molecules onto the surfaces of minerals can significantly decrease the DNA and protein decay rate, the longevity of mineral bound biomolecules is a still-standing frontier. Recently it was shown that peptide sequences in eggshell proteins persist to 3.8 Ma in Africa, implying that protein sequences will span the whole of human history in all parts of the world. Ancient protein sequences, therefore, persist beyond the lipid or DNA sequence and can be used to identify organisms (ZooMS), identify specific tissues, sex individuals, and identify tissue responses to disease. Understanding the protein-mineral interaction and environmental preservative conditions of adsorbed biomolecules – proteins can thus allow us to a) target such environments for paleoecological and palaeogenetic studies and; b) serve as a quantitative tool for assessing protein sequence migration i.e. ancient microbial communities. To date, we only have a qualitative idea of how solution composition affects the protein-mineral adsorption/desorption at the bulk level, and we have no quantitative insight into the single bond level energetics as well as the nature and fraction of the interacting bonds. With ProArc I will: a) assess the proteins preservation state in archaeological samples like calculus and ceramics and other fossil samples. I will also: (b) quantify the Gibbs free energy (ΔGbu) and kinetic bond parameters of in vitro protein-mineral interactions; and (c) examine the nature, fraction and stability of interacting bonds of in vitro protein-mineral associations at the bulk level. (d) Finally, I will make a conceptual model for addressing the characteristics and longevity of different protein-mineral systems.

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The information about "PROARC" are provided by the European Opendata Portal: CORDIS opendata.

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