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Elemental Halogen-Free Reversible Construction and Deconstruction of 1,2-Dihalides via Shuttle Catalysis

Total Cost €


EC-Contrib. €






 HaloCat project word cloud

Explore the words cloud of the HaloCat project. It provides you a very rough idea of what is the project "HaloCat" about.

dihalogenation    competences    construct    reaction    enabled    chemicals    indispensable    versatile    mild    devoted    containing    brf    me    mechanism    hazardous    excellent    practical    transfers    safety    pharmaceuticals    play    interconversion    combined    multi    cl2    combination    serve    daily    fellowship    handling    halogenating    industry    reagents    realize    self    risks    agrochemicals    protocols    alkynes    rare    preliminary    significantly    blocks    chemical    morandi    formal    career    correcting    moiety    unprecedented    independent    suffer    proposes    launch    bromofluorination    first    reversibly    reversible    molecules    deconstruct    world    dramatically    compounds    asymmetric    br2    last    dihalides    harsh    excellence    feasibility    helping    releasing    catalysis    sustainable    expertise    besides    halogenated    materials    enantioselective    zurich    exceedingly    demonstrating    shuttle    corrosive    caused    alkenes    strategy    prof    environment    unmet    tackle    transfer    bromofluorine    eth    scientific    toxic    building    life    unrivaled   

Project "HaloCat" data sheet

The following table provides information about the project.


Organization address
address: Raemistrasse 101
postcode: 8092

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2022-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Multi-halogenated compounds play a significant role in our daily life, as they are not only widely used as materials, pharmaceuticals, and agrochemicals but also serve as practical and indispensable building blocks in the chemical industry. However, most of the existing halogenating protocols suffer from safety risks and harsh reaction conditions caused by toxic and corrosive halogenating reagents (Cl2, Br2). Moreover, the enantioselective 1,2-dihalogenation of alkenes remains an unmet challenge. Besides, practical approaches to the versatile 1,2-bromofluorine-containing building blocks are exceedingly rare. Recently, the shuttle catalysis strategy, which reversibly transfers a chemical moiety between two molecules to construct and deconstruct compounds without handling hazardous reagents, is emerging as a potential strategy to tackle these long-standing challenges. This proposal aims to achieve the shuttle catalysis enabled reversible interconversion of 1,2-dihalides and alkenes/alkynes without using or releasing hazardous chemicals (e.g., Br2, Cl2, and BrF) under mild conditions. The first part is devoted to developing the reversible interconversion between 1,2-dihalides and alkenes. The second part aims to realize the enantioselective Br2 transfer between 1,2-dihalides and alkenes. The last part proposes to develop the unprecedented formal transfer 1,2-bromofluorination of alkenes via a unique self-correcting mechanism. The world-leading research environment of ETH Zurich combined with Prof. Morandi’s unrivaled scientific expertise on shuttle catalysis and my excellent knowledge of asymmetric catalysis offer the best combination to achieve the proposed research. This fellowship will dramatically improve my knowledge and competences, helping me launch my independent career. With promising preliminary results demonstrating the project’s feasibility, the proposed work will significantly contribute to the research excellence and sustainable development of the EU.

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The information about "HALOCAT" are provided by the European Opendata Portal: CORDIS opendata.

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