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DNAGAM SIGNED

DNA-guided self-organized active materials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DNAGAM project word cloud

Explore the words cloud of the DNAGAM project. It provides you a very rough idea of what is the project "DNAGAM" about.

integration    self    unknown    single    gels    embryo    soft    later    autonomous    networks    force    first    multistep    network    action    accomplished    molecular    kinesin    living    exerting    morphogenetic    starting    elusive    morphogenesis    structuring    travelling    inspired    programmable    chemical    apart    proteins    made    biomolecules    instruct    precise    act    levels    biological    precision    morphogen    multiscale    stark    concentrations    spatiotemporal    dependent    indispensable    waves    macroscale    environments    diffusion    latter    kinesins    material    cross    preparation    shape    transformations    host    exert    cells    equilibrium    natural    group    organism    manner    collective    programming    methodology    physicochemical    patterns    modular    organization    biocompatible    shapeless    autonomy    fabricated    conceptually    microtubules    ordered    combined    fronts    entire    morphogens    dna    stranded    diverse    patterned    clusters    morphological    linker    mechanical    predictably    generates    contrast    nanoscale    motor    synthetic    stable    shapes    active    pioneered    man    patterning    guiding    robotics    linking   

Project "DNAGAM" data sheet

The following table provides information about the project.

Coordinator
SORBONNE UNIVERSITE 

Organization address
address: 21 RUE DE L'ECOLE DE MEDECINE
city: PARIS
postcode: 75006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated, force-exerting synthetic soft matter with the potential of integration in soft robotics and biological environments.

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The information about "DNAGAM" are provided by the European Opendata Portal: CORDIS opendata.

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