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DNAGAM SIGNED

DNA-guided self-organized active materials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DNAGAM project word cloud

Explore the words cloud of the DNAGAM project. It provides you a very rough idea of what is the project "DNAGAM" about.

exerting    manner    morphogens    patterning    molecular    indispensable    synthetic    conceptually    combined    active    concentrations    living    preparation    mechanical    apart    modular    macroscale    biocompatible    single    action    latter    force    contrast    equilibrium    pioneered    autonomy    morphogen    generates    stark    ordered    stable    kinesin    shape    linking    cross    morphogenetic    integration    inspired    microtubules    starting    natural    cells    instruct    unknown    methodology    multistep    linker    shapes    man    biomolecules    physicochemical    travelling    structuring    act    material    patterns    elusive    diverse    biological    kinesins    host    motor    programming    first    precision    robotics    transformations    autonomous    networks    later    spatiotemporal    multiscale    gels    entire    guiding    patterned    proteins    morphological    group    nanoscale    made    dependent    embryo    morphogenesis    environments    organism    exert    predictably    network    shapeless    clusters    levels    dna    organization    waves    precise    programmable    soft    accomplished    fabricated    diffusion    fronts    collective    stranded    chemical    self   

Project "DNAGAM" data sheet

The following table provides information about the project.

Coordinator
SORBONNE UNIVERSITE 

Organization address
address: 21 RUE DE L'ECOLE DE MEDECINE
city: PARIS
postcode: 75006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated, force-exerting synthetic soft matter with the potential of integration in soft robotics and biological environments.

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The information about "DNAGAM" are provided by the European Opendata Portal: CORDIS opendata.

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