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DNAGAM SIGNED

DNA-guided self-organized active materials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DNAGAM project word cloud

Explore the words cloud of the DNAGAM project. It provides you a very rough idea of what is the project "DNAGAM" about.

man    macroscale    force    dependent    exert    multiscale    soft    single    morphogens    elusive    pioneered    clusters    fronts    precise    act    programmable    multistep    ordered    combined    environments    mechanical    inspired    diffusion    autonomy    shape    patterns    predictably    patterning    latter    spatiotemporal    synthetic    precision    robotics    microtubules    shapes    morphogenesis    active    cells    indispensable    biocompatible    exerting    stranded    morphogenetic    kinesin    shapeless    guiding    morphological    later    molecular    morphogen    networks    motor    collective    dna    entire    modular    patterned    physicochemical    travelling    transformations    kinesins    material    chemical    nanoscale    starting    programming    levels    fabricated    network    apart    manner    waves    biomolecules    group    action    natural    linker    conceptually    stark    equilibrium    methodology    biological    gels    autonomous    linking    unknown    instruct    preparation    organism    organization    self    proteins    diverse    generates    accomplished    embryo    host    first    stable    cross    integration    concentrations    living    contrast    structuring    made   

Project "DNAGAM" data sheet

The following table provides information about the project.

Coordinator
SORBONNE UNIVERSITE 

Organization address
address: 21 RUE DE L'ECOLE DE MEDECINE
city: PARIS
postcode: 75006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated, force-exerting synthetic soft matter with the potential of integration in soft robotics and biological environments.

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The information about "DNAGAM" are provided by the European Opendata Portal: CORDIS opendata.

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