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DNAGAM SIGNED

DNA-guided self-organized active materials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DNAGAM project word cloud

Explore the words cloud of the DNAGAM project. It provides you a very rough idea of what is the project "DNAGAM" about.

chemical    act    cross    single    gels    fronts    group    structuring    proteins    organization    pioneered    programming    dna    biomolecules    instruct    waves    environments    linking    levels    man    predictably    starting    patterns    entire    autonomy    physicochemical    patterning    biological    stranded    morphogenesis    self    organism    autonomous    preparation    generates    active    equilibrium    action    elusive    biocompatible    molecular    mechanical    soft    modular    linker    concentrations    fabricated    natural    morphogenetic    later    precise    kinesin    multiscale    exerting    exert    synthetic    made    latter    embryo    spatiotemporal    collective    stark    first    apart    ordered    morphogens    cells    clusters    force    indispensable    kinesins    contrast    accomplished    diffusion    morphogen    inspired    integration    programmable    patterned    travelling    diverse    macroscale    shapeless    motor    host    living    dependent    robotics    combined    network    conceptually    shape    unknown    transformations    microtubules    manner    shapes    methodology    nanoscale    guiding    multistep    stable    networks    morphological    precision    material   

Project "DNAGAM" data sheet

The following table provides information about the project.

Coordinator
SORBONNE UNIVERSITE 

Organization address
address: 21 RUE DE L'ECOLE DE MEDECINE
city: PARIS
postcode: 75006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated, force-exerting synthetic soft matter with the potential of integration in soft robotics and biological environments.

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The information about "DNAGAM" are provided by the European Opendata Portal: CORDIS opendata.

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