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DNAGAM SIGNED

DNA-guided self-organized active materials

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 DNAGAM project word cloud

Explore the words cloud of the DNAGAM project. It provides you a very rough idea of what is the project "DNAGAM" about.

dna    entire    molecular    exerting    active    soft    pioneered    programmable    nanoscale    kinesin    autonomy    self    predictably    robotics    gels    motor    stable    generates    man    structuring    morphogens    networks    linker    stark    patterned    concentrations    ordered    later    equilibrium    patterns    waves    fabricated    physicochemical    embryo    biocompatible    levels    dependent    cells    indispensable    autonomous    morphogenetic    collective    action    shapes    synthetic    biological    environments    travelling    accomplished    guiding    preparation    living    fronts    natural    morphogen    morphogenesis    force    integration    morphological    shape    mechanical    multiscale    microtubules    macroscale    single    precise    unknown    diverse    act    chemical    shapeless    cross    manner    clusters    organization    group    exert    made    proteins    organism    modular    programming    instruct    transformations    linking    multistep    combined    elusive    network    contrast    spatiotemporal    first    latter    methodology    diffusion    apart    kinesins    conceptually    stranded    starting    patterning    biomolecules    inspired    material    precision    host   

Project "DNAGAM" data sheet

The following table provides information about the project.

Coordinator
SORBONNE UNIVERSITE 

Organization address
address: 21 RUE DE L'ECOLE DE MEDECINE
city: PARIS
postcode: 75006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated, force-exerting synthetic soft matter with the potential of integration in soft robotics and biological environments.

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The information about "DNAGAM" are provided by the European Opendata Portal: CORDIS opendata.

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