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Damocles SIGNED

Modelling brain aneurysm to elucidate the role of platelets

Total Cost €

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EC-Contrib. €

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Partnership

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 Damocles project word cloud

Explore the words cloud of the Damocles project. It provides you a very rough idea of what is the project "Damocles" about.

questions    recruitment    biophysical    initially    reconstruction    sites    anti    platelet    delineate    intracranial    occurring    hypothesize    mechanisms    interestingly    protective    independently    playing    15    plug    situations    efficient    patients    intervene    subarachnoid    medicine    mainly    pathogenesis    pharmacological    intrasaccular    of    prevent    sah    model    diagnosed    edge    clots    insights    integrity    hemorrhage    vascular    science    aneurysm    activated    evolve    event    functions    life    clinical    hemodynamic    cell    platelets    lack    ruptured    disease    designed    quandary    clot    discovery    therapeutic    invasive    people    thrombus    maintenance    unruptured    ominous    haemorrhage    shear    cardiovascular    inflammation    points    cutting    mouse    preclinical    answer    vivo    yield    window    sac    local    interdisciplinary    inflammatory    union    underlying    biology    safe    signaling    ia    therapies    activation    3d    lingers    rupture    forming    leukocyte    day    stress    later    form    million   

Project "Damocles" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙498˙618 €
 EC max contribution 1˙498˙618 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙498˙618.00

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 Project objective

In the European Union, 15 million people have an unruptured intracranial aneurysm (IA) that may rupture one day and lead to subarachnoid haemorrhage (SAH). The IA rupture event is ominous and lingers as a clinical quandary. No safe and effective non-invasive therapies have, as of yet, been identified and implemented in clinical practice mainly because of a lack of knowledge of the underlying mechanisms. Increasing evidence points to inflammation as one of the leading factors in the pathogenesis of IA. Intrasaccular clot formation is a common feature of IA occurring unruptured and ruptured IA. In addition to forming clots, activated platelets support leukocyte recruitment. Interestingly, platelets also prevent local hemorrhage in inflammatory situations independently of their ability to form a platelet plug.

We hypothesize that the role of platelet may evolve throughout the development of IA: initially playing a protective role of in the maintenance of vascular integrity in response to inflammation and contributing later to intrasaccular thrombus formation. What are the platelet signaling pathways and responses involved and to what extent do they contribute to the disease and the rupture event?

To answer these questions, we designed an interdisciplinary proposal, which gathers biophysical, pharmacological, and in-vivo approaches, with the following objectives: I) To investigate platelet functions from patients diagnosed with intracranial aneurysm at the sites of aneurysm sac. II) To delineate platelet mechanisms and responses in a cutting-edge technology of a 3D reconstruction of IA that will take into account the hemodynamic shear stress. III) To test in a preclinical mouse model of IA efficient anti-platelet therapies and define a therapeutic window to intervene on platelet activation. The proposed project will yield new insights in IA disease and in life science, from cell biology to the discovery of potential new targets in cardiovascular medicine.

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The information about "DAMOCLES" are provided by the European Opendata Portal: CORDIS opendata.

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