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Damocles SIGNED

Modelling brain aneurysm to elucidate the role of platelets

Total Cost €

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EC-Contrib. €

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Partnership

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 Damocles project word cloud

Explore the words cloud of the Damocles project. It provides you a very rough idea of what is the project "Damocles" about.

biophysical    subarachnoid    aneurysm    activation    integrity    mainly    yield    inflammation    clot    shear    therapeutic    efficient    platelet    interdisciplinary    local    interestingly    rupture    preclinical    later    unruptured    protective    ominous    intervene    hypothesize    hemorrhage    signaling    recruitment    sac    discovery    biology    diagnosed    thrombus    stress    delineate    initially    mouse    union    hemodynamic    intrasaccular    3d    platelets    edge    of    patients    vivo    inflammatory    people    designed    evolve    science    invasive    form    forming    disease    pathogenesis    day    questions    mechanisms    activated    pharmacological    ruptured    reconstruction    situations    safe    lack    life    million    quandary    independently    therapies    model    haemorrhage    insights    clots    ia    prevent    window    answer    lingers    15    plug    event    sites    points    occurring    cutting    playing    medicine    functions    maintenance    cardiovascular    anti    leukocyte    intracranial    cell    underlying    clinical    vascular    sah   

Project "Damocles" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙498˙618 €
 EC max contribution 1˙498˙618 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙498˙618.00

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 Project objective

In the European Union, 15 million people have an unruptured intracranial aneurysm (IA) that may rupture one day and lead to subarachnoid haemorrhage (SAH). The IA rupture event is ominous and lingers as a clinical quandary. No safe and effective non-invasive therapies have, as of yet, been identified and implemented in clinical practice mainly because of a lack of knowledge of the underlying mechanisms. Increasing evidence points to inflammation as one of the leading factors in the pathogenesis of IA. Intrasaccular clot formation is a common feature of IA occurring unruptured and ruptured IA. In addition to forming clots, activated platelets support leukocyte recruitment. Interestingly, platelets also prevent local hemorrhage in inflammatory situations independently of their ability to form a platelet plug.

We hypothesize that the role of platelet may evolve throughout the development of IA: initially playing a protective role of in the maintenance of vascular integrity in response to inflammation and contributing later to intrasaccular thrombus formation. What are the platelet signaling pathways and responses involved and to what extent do they contribute to the disease and the rupture event?

To answer these questions, we designed an interdisciplinary proposal, which gathers biophysical, pharmacological, and in-vivo approaches, with the following objectives: I) To investigate platelet functions from patients diagnosed with intracranial aneurysm at the sites of aneurysm sac. II) To delineate platelet mechanisms and responses in a cutting-edge technology of a 3D reconstruction of IA that will take into account the hemodynamic shear stress. III) To test in a preclinical mouse model of IA efficient anti-platelet therapies and define a therapeutic window to intervene on platelet activation. The proposed project will yield new insights in IA disease and in life science, from cell biology to the discovery of potential new targets in cardiovascular medicine.

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The information about "DAMOCLES" are provided by the European Opendata Portal: CORDIS opendata.

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