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BatSECoV SIGNED

Canonical and non-canonical secretory mechanisms of cytokines in bat and human cell cultures in response to coronavirus infection: a comparative study

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BatSECoV project word cloud

Explore the words cloud of the BatSECoV project. It provides you a very rough idea of what is the project "BatSECoV" about.

zoonotic    majority    activation    transfer    innate    cells    science    human    secretion    sars    supernatants    candidate    pathology    releases    interleukins    bats    ifns    divulgation    wellbeing    international    line    subjected    il    implicated    mers    nature    participation    context    coronavirus    interactions    interferons    consist    scientific    strategies    receptors    cytokines    insights    gaps    mechanisms    biology    listed    canonical    community    demographic    viruses    virology    publications    cov    skills    events    analyzing    techniques    press    infections    secretions    molecular    journals    serve    societal    host    culture    details    coronaviruses    multidisciplinary    peer    outcome    responsible    bat    cell    tolerance    combination    lack    health    platform    influence    ifn    strategy    transferable    emerged    congresses    molecules    secretory    fight    virus    training    cytokine    species    knockdowns    mechanistic    immune    reservoir    infected    pathogenic    originally    antiviral   

Project "BatSECoV" data sheet

The following table provides information about the project.

Coordinator		 CHARITE - UNIVERSITAETSMEDIZIN BERLIN 

Organization address
address: Chariteplatz 1
city: BERLIN
postcode: 10117
website: www.charite.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 162˙806 €
 EC max contribution 162˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) coordinator 162˙806.00

Map

 Project objective

The majority of coronaviruses (CoV) originally emerged from bats including highly pathogenic SARS- and MERS-CoV. Bats evolved unique innate immune mechanisms that are likely responsible for the lack of immune pathology. One key process of the immune response is the secretion of cytokines, like interleukins (IL) and type I interferons (IFNs), however molecular details of cytokine secretions and their influence on the outcome of virus infections have not been studied in context of reservoir host species like bats. The aim of this research proposal is to determine the molecular mechanisms involved in the secretion of IL-1 and IFN in human and bat cells that could explain why bats have developed a tolerance against coronavirus infections. The training-through-research of the candidate will consist in analyzing the secretion of IFNs and IL-1 in cell culture supernatants of bat and human CoV-infected cells subjected to knockdowns of different molecules implicated in canonical or non-canonical secretory pathways, as well as activation and interactions between receptors of both secretory pathways. The multidisciplinary nature of the project is strong, involving a combination of well developed molecular biology, cell biology, and virology. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques and transferable skills. The results will show in-depth mechanistic insights into bat cytokine secretion, which still has some gaps in its knowledge, and will serve as a promising platform for the development of new antiviral strategies to fight emerging zoonotic viruses, in line with the EU strategy listed Societal Changes of H2020 for the health, demographic change and wellbeing. The dissemination of the results to the scientific community will be done by publications in international open-access peer-reviewed journals, congresses, press releases and participation at science divulgation events.

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The information about "BATSECOV" are provided by the European Opendata Portal: CORDIS opendata.

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