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ChRONAM-H SIGNED

Chromatin Regulation Of Normal And Malignant Haematopoiesis

Total Cost €

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EC-Contrib. €

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Partnership

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 ChRONAM-H project word cloud

Explore the words cloud of the ChRONAM-H project. It provides you a very rough idea of what is the project "ChRONAM-H" about.

proteins    proposes    category    fight    cellular    proven    insights    central    cfs    compass    molecular    regulatory    dynamic    unexplored    roles    dependent    enzymes    therapeutically    determinants    functions    recurrently    fate    composition    normal    link    regulation    decisions    heterogeneous    fact    largely    centric    works    diverse    unveil    group    polycomb    haematopoiesis    complexes    mechanisms    tfs    multidisciplinary    hematopoiesis    snf    malignancies    swi    locus    chromatin    genome    toolkit    fates    transformation    alterations    fusions    cell    specifying    behavior    of    orthogonally    developmental    profiling    exquisite    throughput    shown    shed    lineage    family    mll    hematopoietic    explore    technologies    blood    protein    networks    epigenetic    little    static    assemble    govern    mutated    combine    light    specification    comprise    drivers    elicit    commitment    transcription    chronam    contribution    leukemia    tf    orchestrate    assembly    relevance    loci    functional    framework    malignant   

Project "ChRONAM-H" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

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 Project objective

Chromatin Factors (CFs) comprise a diverse family of proteins that elicit key regulatory epigenetic activities during the regulation of cellular fates. Although this heterogeneous group has been traditionally considered a static toolkit of epigenetic enzymes deployed to lineage-specific loci under the control of Transcription Factors (TFs), recent works have shown that CFs are crucial determinants of developmental lineage decisions that assemble into dynamic chromatin regulatory complexes with exquisite cell-type-specific composition. Hematopoiesis is a key developmental process largely dependent on Chromatin Factors. Importantly, CFs are the most recurrently mutated protein category across diverse blood malignancies. In fact, alterations in some of these proteins, like MLL fusions, have been proven to be central drivers of malignant transformation. However, in spite of this proven relevance, the contribution of most Chromatin Factors to blood lineage commitment remains largely unexplored; moreover, even for well-studied complexes such as SWI/SNF Polycomb or COMPASS, very little is known about the mechanisms that govern their locus-specific assembly and activity during cell fate specification. My project Chromatin Regulation Of Normal And Malignant Haematopoiesis (ChRONAM-H) proposes a multidisciplinary framework to explore the functions of CFs during hematopoietic lineage commitment and malignant transformation. I will combine high-throughput functional measurements with state-of-the-art chromatin profiling technologies to unveil the lineage specifying roles of a large number of CFs and orthogonally link them within existing TF-centric networks in both normal and malignant hematopoiesis. This will shed light on the molecular behavior of chromatin regulatory complexes, providing new insights about the genome regulatory mechanisms that orchestrate hematopoiesis and how they might be therapeutically targeted to fight leukemia.

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The information about "CHRONAM-H" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-11-27 14:41:53) correctly updated