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ChRONAM-H SIGNED

Chromatin Regulation Of Normal And Malignant Haematopoiesis

Total Cost €

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EC-Contrib. €

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Partnership

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 ChRONAM-H project word cloud

Explore the words cloud of the ChRONAM-H project. It provides you a very rough idea of what is the project "ChRONAM-H" about.

transcription    loci    fusions    snf    throughput    central    largely    regulatory    orthogonally    chronam    govern    epigenetic    functional    polycomb    works    alterations    recurrently    proven    chromatin    swi    comprise    networks    determinants    composition    transformation    orchestrate    dependent    toolkit    compass    specification    lineage    genome    decisions    locus    tf    heterogeneous    malignancies    light    dynamic    commitment    normal    molecular    malignant    protein    combine    category    diverse    assemble    behavior    profiling    therapeutically    haematopoiesis    fight    of    group    little    static    hematopoietic    centric    shown    cell    framework    hematopoiesis    insights    elicit    roles    assembly    technologies    proposes    specifying    unexplored    contribution    enzymes    proteins    leukemia    relevance    explore    multidisciplinary    shed    drivers    mechanisms    functions    link    fate    tfs    mutated    cfs    mll    unveil    family    fates    cellular    fact    blood    regulation    developmental    complexes    exquisite   

Project "ChRONAM-H" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

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 Project objective

Chromatin Factors (CFs) comprise a diverse family of proteins that elicit key regulatory epigenetic activities during the regulation of cellular fates. Although this heterogeneous group has been traditionally considered a static toolkit of epigenetic enzymes deployed to lineage-specific loci under the control of Transcription Factors (TFs), recent works have shown that CFs are crucial determinants of developmental lineage decisions that assemble into dynamic chromatin regulatory complexes with exquisite cell-type-specific composition. Hematopoiesis is a key developmental process largely dependent on Chromatin Factors. Importantly, CFs are the most recurrently mutated protein category across diverse blood malignancies. In fact, alterations in some of these proteins, like MLL fusions, have been proven to be central drivers of malignant transformation. However, in spite of this proven relevance, the contribution of most Chromatin Factors to blood lineage commitment remains largely unexplored; moreover, even for well-studied complexes such as SWI/SNF Polycomb or COMPASS, very little is known about the mechanisms that govern their locus-specific assembly and activity during cell fate specification. My project Chromatin Regulation Of Normal And Malignant Haematopoiesis (ChRONAM-H) proposes a multidisciplinary framework to explore the functions of CFs during hematopoietic lineage commitment and malignant transformation. I will combine high-throughput functional measurements with state-of-the-art chromatin profiling technologies to unveil the lineage specifying roles of a large number of CFs and orthogonally link them within existing TF-centric networks in both normal and malignant hematopoiesis. This will shed light on the molecular behavior of chromatin regulatory complexes, providing new insights about the genome regulatory mechanisms that orchestrate hematopoiesis and how they might be therapeutically targeted to fight leukemia.

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The information about "CHRONAM-H" are provided by the European Opendata Portal: CORDIS opendata.

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