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POMOLIM SIGNED

Polycystic ovarian syndrome: novel molecular characterization and personalized in vitro maturation protocol.

Total Cost €

0

EC-Contrib. €

0

Partnership

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 POMOLIM project word cloud

Explore the words cloud of the POMOLIM project. It provides you a very rough idea of what is the project "POMOLIM" about.

safety    stimulation    found    expression    infertility    parallel    oocyte    cells    home    reported    unknown    safe    pathogenesis    paired    minimal    anckaert    host    ivf    20    kelsey    ccs    women    metabolic    hyperstimulation    derive    dysfunction    acquisition    causative    mild    technologies    risk    hyperandrogenism    paracrine    syndrome    fertilization    human    30    create    granted    sensitivity    hormonal    efficiency    patients    cumulus    signals    vitro    material    ovaries    garnered    sequencing    alterations    epigenetic    gap    tissues    fertility    competence    pcos    single    polycystic    endocrine    morphology    protocol    ovulatory    alternative    treatments    profs    cell    conventional    benefit    generate    secondment    clinic    dr    methylation    cambridge    ivm    molecular    specialized    disorder    suffer    dna    communications    smitz    gene    regulated    ovarian    embryo    profiles    laboratory    pioneering    seeking    prevalence    curtails    maturation    differentially    uk    oocytes    crosstalk    supervisors   

Project "POMOLIM" data sheet

The following table provides information about the project.

Coordinator
VRIJE UNIVERSITEIT BRUSSEL 

Organization address
address: PLEINLAAN 2
city: BRUSSEL
postcode: 1050
website: www.vub.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) coordinator 166˙320.00

Map

 Project objective

Polycystic ovarian syndrome (PCOS) is the leading endocrine and metabolic disorder in women, with a prevalence of 5-20%. It is characterized by hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology and infertility. Epigenetic factors have garnered attention in the pathogenesis of PCOS since changes in DNA methylation and gene expression have been reported in various tissues. Whether these alterations are also found in PCOS oocytes remains unknown. Cumulus cells (CCs) are specialized cells that maintain paracrine signals and cell-to-cell communications with the oocyte to support the acquisition of competence to derive an embryo. This crosstalk is important in PCOS since the reduced oocyte competence is considered the potential causative factor of infertility. PCOS women seeking in vitro fertilization (IVF) treatments suffer greater sensitivity to hormonal treatments, which can lead to a high risk of ovarian hyperstimulation. In vitro maturation (IVM) of oocytes has been introduced in the human fertility clinic as a mild-approach alternative to conventional IVF as it requires minimal stimulation of the ovaries. However, there is a need to further develop a better protocol that curtails the 30% gap efficiency existing between IVM and IVF. This project aims to 1) generate DNA methylation and gene expression profiles of PCOS oocytes and paired CCs using single-cell and low-cell parallel sequencing, 2) create an improved, safe and robust IVM system that can increase oocyte competence for these patients and 3) define the molecular pathways that are differentially regulated in oocytes and CCs after in vitro maturation. The project will benefit from the experience in fertility treatments and safety assessment of the host supervisors, Profs. Smitz and Anckaert. The access to human material will be granted by the home institution. In addition, a secondment in Dr. Kelsey’s laboratory (Cambridge, UK) will provide pioneering single-cell technologies.

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The information about "POMOLIM" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-14 11:49:34) correctly updated