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Polycystic ovarian syndrome: novel molecular characterization and personalized in vitro maturation protocol.

Total Cost €


EC-Contrib. €






 POMOLIM project word cloud

Explore the words cloud of the POMOLIM project. It provides you a very rough idea of what is the project "POMOLIM" about.

pioneering    found    cells    vitro    infertility    dr    pathogenesis    sensitivity    hyperstimulation    create    safe    hyperandrogenism    crosstalk    conventional    generate    competence    sequencing    methylation    granted    women    anckaert    syndrome    reported    derive    cambridge    curtails    home    epigenetic    supervisors    benefit    disorder    embryo    host    risk    dysfunction    communications    uk    secondment    metabolic    laboratory    minimal    oocyte    protocol    gap    treatments    profiles    ovulatory    cumulus    ivm    paracrine    mild    efficiency    prevalence    gene    fertilization    ivf    smitz    hormonal    garnered    dna    profs    material    differentially    tissues    ovarian    signals    technologies    regulated    alterations    molecular    suffer    20    30    safety    patients    causative    kelsey    clinic    pcos    cell    single    polycystic    oocytes    specialized    morphology    paired    ccs    unknown    seeking    fertility    stimulation    endocrine    acquisition    maturation    ovaries    parallel    expression    alternative    human   

Project "POMOLIM" data sheet

The following table provides information about the project.


Organization address
address: PLEINLAAN 2
postcode: 1050

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) coordinator 166˙320.00


 Project objective

Polycystic ovarian syndrome (PCOS) is the leading endocrine and metabolic disorder in women, with a prevalence of 5-20%. It is characterized by hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology and infertility. Epigenetic factors have garnered attention in the pathogenesis of PCOS since changes in DNA methylation and gene expression have been reported in various tissues. Whether these alterations are also found in PCOS oocytes remains unknown. Cumulus cells (CCs) are specialized cells that maintain paracrine signals and cell-to-cell communications with the oocyte to support the acquisition of competence to derive an embryo. This crosstalk is important in PCOS since the reduced oocyte competence is considered the potential causative factor of infertility. PCOS women seeking in vitro fertilization (IVF) treatments suffer greater sensitivity to hormonal treatments, which can lead to a high risk of ovarian hyperstimulation. In vitro maturation (IVM) of oocytes has been introduced in the human fertility clinic as a mild-approach alternative to conventional IVF as it requires minimal stimulation of the ovaries. However, there is a need to further develop a better protocol that curtails the 30% gap efficiency existing between IVM and IVF. This project aims to 1) generate DNA methylation and gene expression profiles of PCOS oocytes and paired CCs using single-cell and low-cell parallel sequencing, 2) create an improved, safe and robust IVM system that can increase oocyte competence for these patients and 3) define the molecular pathways that are differentially regulated in oocytes and CCs after in vitro maturation. The project will benefit from the experience in fertility treatments and safety assessment of the host supervisors, Profs. Smitz and Anckaert. The access to human material will be granted by the home institution. In addition, a secondment in Dr. Kelsey’s laboratory (Cambridge, UK) will provide pioneering single-cell technologies.

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The information about "POMOLIM" are provided by the European Opendata Portal: CORDIS opendata.

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