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POMOLIM SIGNED

Polycystic ovarian syndrome: novel molecular characterization and personalized in vitro maturation protocol.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 POMOLIM project word cloud

Explore the words cloud of the POMOLIM project. It provides you a very rough idea of what is the project "POMOLIM" about.

kelsey    material    polycystic    profiles    create    hyperstimulation    fertilization    ovaries    supervisors    epigenetic    prevalence    derive    ivm    profs    oocytes    efficiency    hormonal    stimulation    cambridge    expression    unknown    pathogenesis    ivf    30    benefit    sensitivity    paracrine    morphology    infertility    treatments    minimal    endocrine    reported    ovarian    uk    crosstalk    risk    molecular    vitro    maturation    pcos    disorder    curtails    seeking    conventional    syndrome    fertility    competence    secondment    ccs    suffer    single    sequencing    communications    tissues    embryo    gap    found    dr    regulated    safe    metabolic    cell    women    ovulatory    causative    dysfunction    anckaert    cumulus    dna    granted    garnered    smitz    host    paired    laboratory    alternative    generate    alterations    differentially    methylation    human    protocol    signals    technologies    patients    safety    pioneering    gene    specialized    20    home    parallel    mild    hyperandrogenism    oocyte    clinic    cells    acquisition   

Project "POMOLIM" data sheet

The following table provides information about the project.

Coordinator
VRIJE UNIVERSITEIT BRUSSEL 

Organization address
address: PLEINLAAN 2
city: BRUSSEL
postcode: 1050
website: www.vub.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) coordinator 166˙320.00

Map

 Project objective

Polycystic ovarian syndrome (PCOS) is the leading endocrine and metabolic disorder in women, with a prevalence of 5-20%. It is characterized by hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology and infertility. Epigenetic factors have garnered attention in the pathogenesis of PCOS since changes in DNA methylation and gene expression have been reported in various tissues. Whether these alterations are also found in PCOS oocytes remains unknown. Cumulus cells (CCs) are specialized cells that maintain paracrine signals and cell-to-cell communications with the oocyte to support the acquisition of competence to derive an embryo. This crosstalk is important in PCOS since the reduced oocyte competence is considered the potential causative factor of infertility. PCOS women seeking in vitro fertilization (IVF) treatments suffer greater sensitivity to hormonal treatments, which can lead to a high risk of ovarian hyperstimulation. In vitro maturation (IVM) of oocytes has been introduced in the human fertility clinic as a mild-approach alternative to conventional IVF as it requires minimal stimulation of the ovaries. However, there is a need to further develop a better protocol that curtails the 30% gap efficiency existing between IVM and IVF. This project aims to 1) generate DNA methylation and gene expression profiles of PCOS oocytes and paired CCs using single-cell and low-cell parallel sequencing, 2) create an improved, safe and robust IVM system that can increase oocyte competence for these patients and 3) define the molecular pathways that are differentially regulated in oocytes and CCs after in vitro maturation. The project will benefit from the experience in fertility treatments and safety assessment of the host supervisors, Profs. Smitz and Anckaert. The access to human material will be granted by the home institution. In addition, a secondment in Dr. Kelsey’s laboratory (Cambridge, UK) will provide pioneering single-cell technologies.

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The information about "POMOLIM" are provided by the European Opendata Portal: CORDIS opendata.

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