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StartAct SIGNED

Controlling forelimb actions through basal ganglia to brainstem signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 StartAct project word cloud

Explore the words cloud of the StartAct project. It provides you a very rough idea of what is the project "StartAct" about.

reticulata    combine    self    unknown    behavioral    discovered    expertise    movement    movements    initiating    career    projections    cord    events    combination    brainstem    ganglia    parvocellular    fine    experiments    pcrt    designed    architecture    understand    forelimb    poorly    stepping    stone    gain    nature    group    neurons    machinery    nigra    leader    independent    designing    behavior    output    anatomy    actions    isolate    impaired    initiates    spinal    opportunity    substantia    sends    initiated    actors    neuronal    lab    reticular    monitoring    basal    foundations    executive    action    centers    blocks    therapies    circuit    linked    signaling    people    arber    receive    behaviors    harbors    inputs    mechanisms    inhibitory    function    distributed    expand    operations    connections    unravel    snr    me    motor    excellent    fellowship    building    supports    mouse    perturbations    disease    physically    circuits    arises    reaching    parkinson    disclose   

Project "StartAct" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 203˙149.00

Map

 Project objective

Behavior arises through the combination of movements within distributed circuits. Most work in the past focused on high motor centers and executive circuits in the spinal cord, but how these systems are linked in order to function is poorly understood. The substantia nigra reticulata (SNR), a basal ganglia output, sends projections to the brainstem. Yet how the brainstem processes these inputs to control actions remains unknown. The Arber lab discovered that the parvocellular reticular formation (PCRt) of the mouse brainstem harbors neurons controlling forelimb behaviors including reaching. PCRt neurons receive inhibitory inputs from the SNR. Thus, the SNR-PCRt circuit is an excellent stepping stone for understanding the mechanisms behind self-initiated actions. I propose to investigate the impact of the SNR signaling on the activity of PCRt neurons when a mouse self-initiates forelimb reaching. I will characterize the anatomy and nature of SNR to PCRt connections to understand whether and how this architecture supports forelimb movement. I will combine a behavioral task designed to isolate the neuronal events around the triggering of a self-initiated action with loss- and gain of function perturbations to unravel the building blocks of self-initiated actions. Finally, I will use the task while monitoring the activity of specific SNR and PCRt neurons to understand how the different actors physically implement the operations for self-initiated actions. Together, my experiments will disclose the fine-scale machinery for initiating and controlling an action. This level of understanding is key for designing new therapies to help people impaired in self- initiating actions such in Parkinson’s disease. The fellowship will provide me with the unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

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The information about "STARTACT" are provided by the European Opendata Portal: CORDIS opendata.

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