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StartAct SIGNED

Controlling forelimb actions through basal ganglia to brainstem signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 StartAct project word cloud

Explore the words cloud of the StartAct project. It provides you a very rough idea of what is the project "StartAct" about.

neurons    spinal    initiates    understand    centers    self    expertise    neuronal    experiments    supports    machinery    unravel    pcrt    designed    group    movements    basal    excellent    career    behavior    fine    actions    parkinson    distributed    output    disease    monitoring    blocks    brainstem    perturbations    opportunity    fellowship    mouse    ganglia    executive    behavioral    people    initiated    parvocellular    receive    behaviors    initiating    expand    linked    stepping    connections    substantia    reaching    lab    forelimb    nature    reticular    circuit    inputs    anatomy    architecture    action    movement    cord    discovered    stone    leader    harbors    operations    motor    designing    inhibitory    unknown    therapies    gain    reticulata    events    poorly    combine    impaired    arber    physically    me    arises    disclose    nigra    isolate    building    mechanisms    projections    actors    sends    circuits    snr    signaling    foundations    independent    combination    function   

Project "StartAct" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 203˙149.00

Map

 Project objective

Behavior arises through the combination of movements within distributed circuits. Most work in the past focused on high motor centers and executive circuits in the spinal cord, but how these systems are linked in order to function is poorly understood. The substantia nigra reticulata (SNR), a basal ganglia output, sends projections to the brainstem. Yet how the brainstem processes these inputs to control actions remains unknown. The Arber lab discovered that the parvocellular reticular formation (PCRt) of the mouse brainstem harbors neurons controlling forelimb behaviors including reaching. PCRt neurons receive inhibitory inputs from the SNR. Thus, the SNR-PCRt circuit is an excellent stepping stone for understanding the mechanisms behind self-initiated actions. I propose to investigate the impact of the SNR signaling on the activity of PCRt neurons when a mouse self-initiates forelimb reaching. I will characterize the anatomy and nature of SNR to PCRt connections to understand whether and how this architecture supports forelimb movement. I will combine a behavioral task designed to isolate the neuronal events around the triggering of a self-initiated action with loss- and gain of function perturbations to unravel the building blocks of self-initiated actions. Finally, I will use the task while monitoring the activity of specific SNR and PCRt neurons to understand how the different actors physically implement the operations for self-initiated actions. Together, my experiments will disclose the fine-scale machinery for initiating and controlling an action. This level of understanding is key for designing new therapies to help people impaired in self- initiating actions such in Parkinson’s disease. The fellowship will provide me with the unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

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The information about "STARTACT" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-18 16:17:27) correctly updated