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StartAct SIGNED

Controlling forelimb actions through basal ganglia to brainstem signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 StartAct project word cloud

Explore the words cloud of the StartAct project. It provides you a very rough idea of what is the project "StartAct" about.

poorly    blocks    fellowship    combination    disease    group    mouse    nature    circuit    neuronal    executive    substantia    anatomy    therapies    actors    reticulata    nigra    physically    arber    expand    forelimb    signaling    inputs    action    lab    architecture    career    sends    supports    pcrt    movement    reticular    cord    mechanisms    designing    connections    fine    initiating    operations    initiated    centers    movements    monitoring    brainstem    basal    behavioral    isolate    combine    inhibitory    spinal    harbors    gain    understand    perturbations    actions    discovered    unknown    distributed    expertise    stepping    behavior    parvocellular    motor    snr    experiments    excellent    neurons    projections    building    output    designed    events    circuits    behaviors    impaired    arises    independent    disclose    ganglia    self    parkinson    reaching    receive    linked    people    machinery    me    stone    opportunity    unravel    leader    initiates    foundations    function   

Project "StartAct" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 203˙149.00

Map

 Project objective

Behavior arises through the combination of movements within distributed circuits. Most work in the past focused on high motor centers and executive circuits in the spinal cord, but how these systems are linked in order to function is poorly understood. The substantia nigra reticulata (SNR), a basal ganglia output, sends projections to the brainstem. Yet how the brainstem processes these inputs to control actions remains unknown. The Arber lab discovered that the parvocellular reticular formation (PCRt) of the mouse brainstem harbors neurons controlling forelimb behaviors including reaching. PCRt neurons receive inhibitory inputs from the SNR. Thus, the SNR-PCRt circuit is an excellent stepping stone for understanding the mechanisms behind self-initiated actions. I propose to investigate the impact of the SNR signaling on the activity of PCRt neurons when a mouse self-initiates forelimb reaching. I will characterize the anatomy and nature of SNR to PCRt connections to understand whether and how this architecture supports forelimb movement. I will combine a behavioral task designed to isolate the neuronal events around the triggering of a self-initiated action with loss- and gain of function perturbations to unravel the building blocks of self-initiated actions. Finally, I will use the task while monitoring the activity of specific SNR and PCRt neurons to understand how the different actors physically implement the operations for self-initiated actions. Together, my experiments will disclose the fine-scale machinery for initiating and controlling an action. This level of understanding is key for designing new therapies to help people impaired in self- initiating actions such in Parkinson’s disease. The fellowship will provide me with the unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

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The information about "STARTACT" are provided by the European Opendata Portal: CORDIS opendata.

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