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StartAct SIGNED

Controlling forelimb actions through basal ganglia to brainstem signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 StartAct project word cloud

Explore the words cloud of the StartAct project. It provides you a very rough idea of what is the project "StartAct" about.

arber    executive    distributed    pcrt    expertise    spinal    nigra    initiates    independent    projections    stone    linked    motor    circuit    lab    isolate    machinery    arises    therapies    snr    physically    centers    parvocellular    ganglia    movement    designed    me    neurons    inhibitory    actions    circuits    reaching    output    building    impaired    reticulata    self    actors    harbors    perturbations    inputs    designing    leader    understand    expand    nature    initiated    basal    blocks    connections    stepping    forelimb    events    group    brainstem    disease    behavior    combination    foundations    signaling    discovered    cord    unravel    behavioral    behaviors    opportunity    operations    gain    mechanisms    fine    poorly    function    neuronal    fellowship    action    reticular    receive    disclose    unknown    sends    experiments    people    architecture    monitoring    combine    supports    substantia    career    anatomy    mouse    excellent    movements    parkinson    initiating   

Project "StartAct" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 203˙149.00

Map

 Project objective

Behavior arises through the combination of movements within distributed circuits. Most work in the past focused on high motor centers and executive circuits in the spinal cord, but how these systems are linked in order to function is poorly understood. The substantia nigra reticulata (SNR), a basal ganglia output, sends projections to the brainstem. Yet how the brainstem processes these inputs to control actions remains unknown. The Arber lab discovered that the parvocellular reticular formation (PCRt) of the mouse brainstem harbors neurons controlling forelimb behaviors including reaching. PCRt neurons receive inhibitory inputs from the SNR. Thus, the SNR-PCRt circuit is an excellent stepping stone for understanding the mechanisms behind self-initiated actions. I propose to investigate the impact of the SNR signaling on the activity of PCRt neurons when a mouse self-initiates forelimb reaching. I will characterize the anatomy and nature of SNR to PCRt connections to understand whether and how this architecture supports forelimb movement. I will combine a behavioral task designed to isolate the neuronal events around the triggering of a self-initiated action with loss- and gain of function perturbations to unravel the building blocks of self-initiated actions. Finally, I will use the task while monitoring the activity of specific SNR and PCRt neurons to understand how the different actors physically implement the operations for self-initiated actions. Together, my experiments will disclose the fine-scale machinery for initiating and controlling an action. This level of understanding is key for designing new therapies to help people impaired in self- initiating actions such in Parkinson’s disease. The fellowship will provide me with the unique opportunity to expand my expertise and establish the foundations of my future career as an independent group leader.

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The information about "STARTACT" are provided by the European Opendata Portal: CORDIS opendata.

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