Opendata, web and dolomites

SPHERES SIGNED

Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SPHERES project word cloud

Explore the words cloud of the SPHERES project. It provides you a very rough idea of what is the project "SPHERES" about.

cides    irrespective    turnover    vivo    ld    understand    variations    maintenance    tgs    pathological    joint    mouse    gene    disturbances    phospholipid    core    link    droplet    functional    organelle    dynamics    determines    mass    therapeutic    clinical    interactions    jointly    size    effort    energy    pis    stability    storing    spheroid    individual    cellular    eacute    cultures    alter    imaging    mechanisms    regulate    diseases    monolayer    deleterious    investigations    postulate    lds    labelling    specialized    notably    composition    spheres    prevalent    biophysical    body    ryd    reconstitution    phenotype    inter    investigation    expertise    unanswered    native    human    adipocyte    structure    adipocytes    editing    lipases    strategies    workers    antonny    langin    identification    molecular    cell    questions    lipid    fat    cardiometabolic    co    preparation    models    discover    altogether    surface    triglycerides    pathogenic    ex    hypertrophy    proteins    spanning    proximity    achievable    enlargement    perilipins    tg    fundamental   

Project "SPHERES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PAUL SABATIER TOULOUSE III 

Organization address
address: ROUTE DE NARBONNE 118
city: TOULOUSE CEDEX 9
postcode: 31062
website: www.ups-tlse.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 9˙741˙774 €
 EC max contribution 9˙741˙774 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2026-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PAUL SABATIER TOULOUSE III FR (TOULOUSE CEDEX 9) coordinator 3˙537˙143.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 3˙199˙750.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 3˙004˙881.00

Map

 Project objective

The goal of SPHERES is to understand the dynamics and consequences of adipocyte hypertrophy (enlargement) through investigation of its large lipid droplet (LD). The adipocyte LD is a unique organelle specialized in storing energy in triglycerides (TGs). Its surface is composed of a phospholipid monolayer and specific LD-associated proteins (such as perilipins, CIDEs and lipases), which jointly regulate LD stability and TG turnover. Adipocyte hypertrophy due to an increase in LD size may, irrespective of body fat mass, cause a wide range of pathological conditions, notably cardiometabolic diseases. SPHERES PIs (Langin, Rydén, Antonny) postulate that disturbances in the interactions between LD proteins and LD lipid composition lead to adipocyte hypertrophy and its deleterious consequences. We have identified three fundamental unanswered questions: what determines the unique structure and dynamics of large LD; why does increased LD size alter the functional phenotype of the adipocyte; which factors cause inter-individual variations in LD size. To address these questions, SPHERES gathers expertise in clinical and cellular studies on human adipocytes, in/ex vivo investigations in mouse models, and biophysical analyses of LDs. At the core of this application is the development of beyond-state-of-the-art models and methods (spheroid cultures, native large LD preparation and reconstitution, proximity labelling of LD proteins, gene editing in cell and mouse models, and advanced LD imaging), only achievable through joint integrated effort of the PIs and co-workers. Spanning from molecular, cellular to the whole-body level, SPHERES will link new knowledge on the formation and maintenance of large adipocyte LDs to the deleterious impact of adipocyte hypertrophy. Altogether, SPHERES has a strong potential to discover novel pathogenic mechanisms, leading to a better understanding of highly prevalent diseases and identification of therapeutic strategies targeting adipocytes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SPHERES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SPHERES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SmartForests (2020)

Smart Forests: Transforming Environments into Social-Political Technologies

Read More  

DYNAPOL (2019)

Modeling approaches toward bioinspired dynamic materials

Read More  

INFANT MEMORIES (2020)

Dissecting hippocampal circuits for the encoding of early-life memories

Read More