Opendata, web and dolomites

SPHERES SIGNED

Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SPHERES project word cloud

Explore the words cloud of the SPHERES project. It provides you a very rough idea of what is the project "SPHERES" about.

achievable    individual    functional    cultures    mechanisms    adipocytes    workers    droplet    lipases    phospholipid    inter    deleterious    lds    size    alter    questions    antonny    reconstitution    phenotype    link    tgs    specialized    interactions    pathological    investigations    ryd    surface    irrespective    biophysical    identification    pis    hypertrophy    tg    investigation    perilipins    triglycerides    effort    understand    maintenance    regulate    unanswered    proteins    spheres    cides    joint    ld    mass    energy    native    discover    gene    human    prevalent    core    cellular    strategies    molecular    pathogenic    preparation    proximity    imaging    therapeutic    expertise    vivo    co    ex    monolayer    fat    determines    spheroid    variations    adipocyte    notably    cell    clinical    composition    postulate    organelle    fundamental    lipid    labelling    spanning    dynamics    eacute    stability    enlargement    jointly    langin    altogether    mouse    body    disturbances    structure    models    turnover    diseases    editing    cardiometabolic    storing   

Project "SPHERES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PAUL SABATIER TOULOUSE III 

Organization address
address: ROUTE DE NARBONNE 118
city: TOULOUSE CEDEX 9
postcode: 31062
website: www.ups-tlse.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 9˙741˙774 €
 EC max contribution 9˙741˙774 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2026-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PAUL SABATIER TOULOUSE III FR (TOULOUSE CEDEX 9) coordinator 3˙537˙143.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 3˙199˙750.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 3˙004˙881.00

Map

 Project objective

The goal of SPHERES is to understand the dynamics and consequences of adipocyte hypertrophy (enlargement) through investigation of its large lipid droplet (LD). The adipocyte LD is a unique organelle specialized in storing energy in triglycerides (TGs). Its surface is composed of a phospholipid monolayer and specific LD-associated proteins (such as perilipins, CIDEs and lipases), which jointly regulate LD stability and TG turnover. Adipocyte hypertrophy due to an increase in LD size may, irrespective of body fat mass, cause a wide range of pathological conditions, notably cardiometabolic diseases. SPHERES PIs (Langin, Rydén, Antonny) postulate that disturbances in the interactions between LD proteins and LD lipid composition lead to adipocyte hypertrophy and its deleterious consequences. We have identified three fundamental unanswered questions: what determines the unique structure and dynamics of large LD; why does increased LD size alter the functional phenotype of the adipocyte; which factors cause inter-individual variations in LD size. To address these questions, SPHERES gathers expertise in clinical and cellular studies on human adipocytes, in/ex vivo investigations in mouse models, and biophysical analyses of LDs. At the core of this application is the development of beyond-state-of-the-art models and methods (spheroid cultures, native large LD preparation and reconstitution, proximity labelling of LD proteins, gene editing in cell and mouse models, and advanced LD imaging), only achievable through joint integrated effort of the PIs and co-workers. Spanning from molecular, cellular to the whole-body level, SPHERES will link new knowledge on the formation and maintenance of large adipocyte LDs to the deleterious impact of adipocyte hypertrophy. Altogether, SPHERES has a strong potential to discover novel pathogenic mechanisms, leading to a better understanding of highly prevalent diseases and identification of therapeutic strategies targeting adipocytes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SPHERES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SPHERES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More