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SPHERES SIGNED

Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Total Cost €

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EC-Contrib. €

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Partnership

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 SPHERES project word cloud

Explore the words cloud of the SPHERES project. It provides you a very rough idea of what is the project "SPHERES" about.

co    langin    lipid    phospholipid    ex    cell    specialized    mouse    lds    functional    investigation    reconstitution    adipocytes    preparation    therapeutic    perilipins    dynamics    prevalent    maintenance    triglycerides    expertise    core    vivo    investigations    workers    adipocyte    understand    unanswered    link    variations    strategies    body    spheres    achievable    cides    fundamental    eacute    structure    diseases    organelle    surface    effort    discover    pis    postulate    cardiometabolic    hypertrophy    jointly    native    notably    ryd    biophysical    deleterious    storing    molecular    tg    mass    pathological    cellular    pathogenic    clinical    proximity    phenotype    gene    cultures    fat    questions    lipases    enlargement    disturbances    irrespective    joint    regulate    labelling    human    altogether    turnover    inter    ld    imaging    alter    interactions    stability    antonny    proteins    identification    tgs    determines    droplet    mechanisms    individual    size    spanning    monolayer    energy    models    editing    spheroid    composition   

Project "SPHERES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PAUL SABATIER TOULOUSE III 

Organization address
address: ROUTE DE NARBONNE 118
city: TOULOUSE CEDEX 9
postcode: 31062
website: www.ups-tlse.fr

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country France [FR]
 Total cost 9˙741˙774 €
 EC max contribution 9˙741˙774 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2026-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PAUL SABATIER TOULOUSE III FR (TOULOUSE CEDEX 9) coordinator 3˙537˙143.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 3˙199˙750.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 3˙004˙881.00

Map

 Project objective

The goal of SPHERES is to understand the dynamics and consequences of adipocyte hypertrophy (enlargement) through investigation of its large lipid droplet (LD). The adipocyte LD is a unique organelle specialized in storing energy in triglycerides (TGs). Its surface is composed of a phospholipid monolayer and specific LD-associated proteins (such as perilipins, CIDEs and lipases), which jointly regulate LD stability and TG turnover. Adipocyte hypertrophy due to an increase in LD size may, irrespective of body fat mass, cause a wide range of pathological conditions, notably cardiometabolic diseases. SPHERES PIs (Langin, Rydén, Antonny) postulate that disturbances in the interactions between LD proteins and LD lipid composition lead to adipocyte hypertrophy and its deleterious consequences. We have identified three fundamental unanswered questions: what determines the unique structure and dynamics of large LD; why does increased LD size alter the functional phenotype of the adipocyte; which factors cause inter-individual variations in LD size. To address these questions, SPHERES gathers expertise in clinical and cellular studies on human adipocytes, in/ex vivo investigations in mouse models, and biophysical analyses of LDs. At the core of this application is the development of beyond-state-of-the-art models and methods (spheroid cultures, native large LD preparation and reconstitution, proximity labelling of LD proteins, gene editing in cell and mouse models, and advanced LD imaging), only achievable through joint integrated effort of the PIs and co-workers. Spanning from molecular, cellular to the whole-body level, SPHERES will link new knowledge on the formation and maintenance of large adipocyte LDs to the deleterious impact of adipocyte hypertrophy. Altogether, SPHERES has a strong potential to discover novel pathogenic mechanisms, leading to a better understanding of highly prevalent diseases and identification of therapeutic strategies targeting adipocytes.

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The information about "SPHERES" are provided by the European Opendata Portal: CORDIS opendata.

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