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ANTIBIOCLICKS SIGNED

BioInspired Clicked Siderophore-Antibiotics

Total Cost €

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EC-Contrib. €

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Partnership

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 ANTIBIOCLICKS project word cloud

Explore the words cloud of the ANTIBIOCLICKS project. It provides you a very rough idea of what is the project "ANTIBIOCLICKS" about.

resistance    combinatorial    inspired    antibioclicks    organisation    chemistry    natural    conjugation    infections    aeruginosa    tuberculosis    obstacle    library    pneumonia    uncovered    prioritised    fluorophores    siderophore    bacterial    programs    molecules    strategies    health    newly    decoupling    conjugates    threatening    illuminating    enter    coli    chemical    surprisingly    inhibitors    exact    global    classes    machinery    intracellular    engagement    drug    siderophores    acquisition    negative    exemplified    sideromycin    trojan    diagnostic    healthcare    facile    mechanism    scarce    synthesis    antibiotic    gram    subsequently    bacteria    nosocomial    stealth    sideromycins    frightening    world    preclinical    containing    horse    antibiotics    candidate    examples    discovered    probe    generate    coupling    iron    discovery    highest    cefiderocol    catecholate    ideal    diagnostics    click    strategy    therapeutics    bioinspired    baumannii    despite    piggyback    reaction   

Project "ANTIBIOCLICKS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙000˙000.00

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 Project objective

The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback the bacterial iron acquisition machinery to enter bacteria. This Trojan-horse strategy has inspired the chemical synthesis of numerous sideromycin conjugates, with cefiderocol a current preclinical candidate. Despite the advances in this field, natural examples of sideromycins are still scarce, and finding new examples may provide further insight into siderophore antibiotic formation and delivery.

ANTIBIOCLICKS will investigate a unique bioinspired conjugation chemistry that has been uncovered from a newly discovered natural sideromycin. This natural “click” chemistry is ideal for the coupling of catecholate containing siderophores (such as those of the WHO prioritised M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia) to antibiotics or other molecules. This project will aim to define the exact chemical mechanism behind this novel and surprisingly simple conjugation reaction, and use this unique and facile chemistry to generate a combinatorial library of siderophores with antibiotics and fluorophores. These products will subsequently be used to probe the exact mechanism of bacterial sideromycin uptake, potential intracellular decoupling and target engagement. Finally, the antibiotic and diagnostic potential of the generated siderophore conjugates will be evaluated. To this extent, ANTIBIOCLICKS will provide illuminating insight into new bioinspired conjugation chemistry, and evaluate its potential for novel bacterial therapeutics and diagnostics.

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The information about "ANTIBIOCLICKS" are provided by the European Opendata Portal: CORDIS opendata.

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