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ANTIBIOCLICKS SIGNED

BioInspired Clicked Siderophore-Antibiotics

Total Cost €

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EC-Contrib. €

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Partnership

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 ANTIBIOCLICKS project word cloud

Explore the words cloud of the ANTIBIOCLICKS project. It provides you a very rough idea of what is the project "ANTIBIOCLICKS" about.

acquisition    despite    illuminating    negative    library    aeruginosa    mechanism    coli    horse    baumannii    strategies    click    preclinical    siderophores    nosocomial    trojan    containing    exemplified    reaction    sideromycin    therapeutics    highest    antibiotic    antibiotics    global    bacterial    pneumonia    diagnostic    combinatorial    strategy    antibioclicks    diagnostics    conjugates    tuberculosis    chemistry    examples    drug    conjugation    surprisingly    obstacle    catecholate    bacteria    probe    machinery    cefiderocol    scarce    infections    ideal    uncovered    frightening    bioinspired    inhibitors    healthcare    decoupling    iron    synthesis    chemical    inspired    piggyback    facile    exact    organisation    prioritised    gram    discovery    stealth    subsequently    sideromycins    world    resistance    intracellular    health    programs    molecules    newly    threatening    natural    siderophore    enter    engagement    coupling    generate    candidate    discovered    classes    fluorophores   

Project "ANTIBIOCLICKS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙000˙000.00

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 Project objective

The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback the bacterial iron acquisition machinery to enter bacteria. This Trojan-horse strategy has inspired the chemical synthesis of numerous sideromycin conjugates, with cefiderocol a current preclinical candidate. Despite the advances in this field, natural examples of sideromycins are still scarce, and finding new examples may provide further insight into siderophore antibiotic formation and delivery.

ANTIBIOCLICKS will investigate a unique bioinspired conjugation chemistry that has been uncovered from a newly discovered natural sideromycin. This natural “click” chemistry is ideal for the coupling of catecholate containing siderophores (such as those of the WHO prioritised M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia) to antibiotics or other molecules. This project will aim to define the exact chemical mechanism behind this novel and surprisingly simple conjugation reaction, and use this unique and facile chemistry to generate a combinatorial library of siderophores with antibiotics and fluorophores. These products will subsequently be used to probe the exact mechanism of bacterial sideromycin uptake, potential intracellular decoupling and target engagement. Finally, the antibiotic and diagnostic potential of the generated siderophore conjugates will be evaluated. To this extent, ANTIBIOCLICKS will provide illuminating insight into new bioinspired conjugation chemistry, and evaluate its potential for novel bacterial therapeutics and diagnostics.

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The information about "ANTIBIOCLICKS" are provided by the European Opendata Portal: CORDIS opendata.

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