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ANTIBIOCLICKS SIGNED

BioInspired Clicked Siderophore-Antibiotics

Total Cost €

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EC-Contrib. €

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Partnership

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 ANTIBIOCLICKS project word cloud

Explore the words cloud of the ANTIBIOCLICKS project. It provides you a very rough idea of what is the project "ANTIBIOCLICKS" about.

classes    click    coli    prioritised    acquisition    therapeutics    scarce    bacterial    highest    tuberculosis    subsequently    uncovered    organisation    conjugation    mechanism    trojan    examples    frightening    iron    despite    sideromycins    bacteria    containing    threatening    nosocomial    surprisingly    obstacle    strategies    probe    machinery    bioinspired    antibiotic    library    combinatorial    discovery    catecholate    world    engagement    piggyback    coupling    baumannii    discovered    drug    antibiotics    illuminating    exemplified    strategy    healthcare    conjugates    siderophores    enter    stealth    global    generate    antibioclicks    reaction    intracellular    chemical    negative    aeruginosa    natural    inspired    programs    resistance    inhibitors    molecules    diagnostic    preclinical    fluorophores    chemistry    diagnostics    facile    gram    decoupling    sideromycin    cefiderocol    exact    siderophore    horse    candidate    synthesis    ideal    pneumonia    infections    newly    health   

Project "ANTIBIOCLICKS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙000˙000.00

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 Project objective

The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback the bacterial iron acquisition machinery to enter bacteria. This Trojan-horse strategy has inspired the chemical synthesis of numerous sideromycin conjugates, with cefiderocol a current preclinical candidate. Despite the advances in this field, natural examples of sideromycins are still scarce, and finding new examples may provide further insight into siderophore antibiotic formation and delivery.

ANTIBIOCLICKS will investigate a unique bioinspired conjugation chemistry that has been uncovered from a newly discovered natural sideromycin. This natural “click” chemistry is ideal for the coupling of catecholate containing siderophores (such as those of the WHO prioritised M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia) to antibiotics or other molecules. This project will aim to define the exact chemical mechanism behind this novel and surprisingly simple conjugation reaction, and use this unique and facile chemistry to generate a combinatorial library of siderophores with antibiotics and fluorophores. These products will subsequently be used to probe the exact mechanism of bacterial sideromycin uptake, potential intracellular decoupling and target engagement. Finally, the antibiotic and diagnostic potential of the generated siderophore conjugates will be evaluated. To this extent, ANTIBIOCLICKS will provide illuminating insight into new bioinspired conjugation chemistry, and evaluate its potential for novel bacterial therapeutics and diagnostics.

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The information about "ANTIBIOCLICKS" are provided by the European Opendata Portal: CORDIS opendata.

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