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ANTIBIOCLICKS SIGNED

BioInspired Clicked Siderophore-Antibiotics

Total Cost €

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EC-Contrib. €

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Partnership

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 ANTIBIOCLICKS project word cloud

Explore the words cloud of the ANTIBIOCLICKS project. It provides you a very rough idea of what is the project "ANTIBIOCLICKS" about.

sideromycins    illuminating    candidate    reaction    fluorophores    click    surprisingly    inspired    drug    diagnostic    discovered    decoupling    preclinical    aeruginosa    examples    organisation    subsequently    exemplified    natural    classes    threatening    antibiotic    cefiderocol    nosocomial    iron    enter    stealth    synthesis    pneumonia    global    bacteria    highest    siderophore    frightening    library    facile    antibioclicks    sideromycin    engagement    intracellular    probe    piggyback    infections    mechanism    chemical    horse    generate    trojan    antibiotics    inhibitors    bacterial    health    combinatorial    chemistry    programs    newly    bioinspired    molecules    resistance    discovery    ideal    coli    obstacle    siderophores    prioritised    catecholate    containing    tuberculosis    gram    therapeutics    strategy    world    conjugation    baumannii    diagnostics    despite    acquisition    uncovered    conjugates    exact    machinery    scarce    negative    coupling    strategies    healthcare   

Project "ANTIBIOCLICKS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2025-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙000˙000.00

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 Project objective

The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback the bacterial iron acquisition machinery to enter bacteria. This Trojan-horse strategy has inspired the chemical synthesis of numerous sideromycin conjugates, with cefiderocol a current preclinical candidate. Despite the advances in this field, natural examples of sideromycins are still scarce, and finding new examples may provide further insight into siderophore antibiotic formation and delivery.

ANTIBIOCLICKS will investigate a unique bioinspired conjugation chemistry that has been uncovered from a newly discovered natural sideromycin. This natural “click” chemistry is ideal for the coupling of catecholate containing siderophores (such as those of the WHO prioritised M. tuberculosis, A. baumannii, E. coli, P. aeruginosa and K. pneumonia) to antibiotics or other molecules. This project will aim to define the exact chemical mechanism behind this novel and surprisingly simple conjugation reaction, and use this unique and facile chemistry to generate a combinatorial library of siderophores with antibiotics and fluorophores. These products will subsequently be used to probe the exact mechanism of bacterial sideromycin uptake, potential intracellular decoupling and target engagement. Finally, the antibiotic and diagnostic potential of the generated siderophore conjugates will be evaluated. To this extent, ANTIBIOCLICKS will provide illuminating insight into new bioinspired conjugation chemistry, and evaluate its potential for novel bacterial therapeutics and diagnostics.

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The information about "ANTIBIOCLICKS" are provided by the European Opendata Portal: CORDIS opendata.

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