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Heart Fi-Re SIGNED

HEART FIne REgulation through mechanosensing in myosin filaments: merging theory and experiments into a multi-scale heart simulator

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Heart Fi-Re project word cloud

Explore the words cloud of the Heart Fi-Re project. It provides you a very rough idea of what is the project "Heart Fi-Re" about.

interdisciplinary    experimentally    concentration    models    heart    muscle    collaborations    mechanism    observations    cycle    excellence    regulates    cardiomyopathies    filament    evidences    multi    tension    generate    knowledges    treatments    respect    unresolved    finely    limited    network    purely    myosin    regulator    law    contraction    performance    frank    quantitatively    mathematical    description    establishing    ready    predicted    patient    deserving    clinical    ms    innovative    powerful    international    fibre    discovered    mechanosensing    sensing    motors    link    edge    sustained    model    clear    firm    stage    starling    fine    simulators    complementary    techniques    cutting    force    world    groups    validate    questions    foundation    calcium    cardiac    complimentary    node    career    host    health    experimental    basis    molecular    regulation    active    appears    simulator    expertise    phenomenological    few    interaction    institutes    relationships    macroscopic    theoretical    thick   

Project "Heart Fi-Re" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 276˙498 €
 EC max contribution 276˙498 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-GF
 Starting year 2021
 Duration (year-month-day) from 2021-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 276˙498.00
2    RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH JP (WAKO SHI SAITAMA) partner 0.00

Map

 Project objective

Multi-scale heart simulators for patient specific treatments are an important challenge for the development of the health system, but require interdisciplinary interaction of several techniques to link experimental observations at the molecular level to the cardiac performance. The mechanosensing (MS) mechanism active in the myosin thick filament, recently discovered, is promising for the understanding of several unresolved questions in muscle field, including the molecular basis of the Frank-Starling law of the heart. MS mechanism finely regulates the number of myosin motors ready to generate force, sensing the tension sustained by the thick filament in any stage of the heart cycle. The mechanism appears to be crucial for the fine regulation of muscle contraction, deserving as a second regulator respect the classical Calcium concentration. However, its theoretical description at present is limited to purely phenomenological models and very few groups in the world are already able to produce clear evidences on it. The present project aims at establishing a collaboration between researchers in this field with complementary theoretical and experimental expertise to quantitatively characterize the MS mechanism at the fibre level through an innovative mathematical model and experimentally validate it with cutting-edge techniques present in the host and partner institutes. The fibre model will be included into a powerful whole heart simulator, to evaluate the macroscopic impact of MS mechanism, and its predicted effects on clinical problems, including its recently discovered relationships with cardiomyopathies. The project will foster an international network of collaborations, where the host institution will be a crucial node. The complimentary knowledges and high excellence of the groups, is a firm foundation on which to build the impact of the project: at my career level, at the institutes level and also at the system level.

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The information about "HEART FI-RE" are provided by the European Opendata Portal: CORDIS opendata.

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