The development of precision and personalized medicine, notably in cancer, leads to an explosion in the cost of research, clinical trials, diagnosis and treatment. It calls for a change of paradigm in cell-based personalized models, allowing-high throughput screening of large panels of drugs at low cost and on minute samples. We invented in ERCadg CellO a new technology “Free-Flow Textile Chips” (FFTC) proving a solution to the above problem. It allows the production of high-resolution complex microfluidic devices at very low cost using the power of the textile industry. Using this technology we developed an automated platform able to generate, from a single micro-biopsy, a large number of 3D tumor cell spheroids encapsulated within individual nanoliter droplets, and to screen them against tens of drug combinations. This platform will reduce the time, sample size, cost of screening and drugs consumption per assay by factors ranging from 10 to 1000. This will in turn replace animal testing, and allow low-cost high-content drug screening and affordable precision medicine. This new platform will be tested versus conventional techniques in a real world context, and steps towards industrialization will be taken. We shall first target the market of research laboratories and drug development in the pharmaceutical industry, but also prepare clinical applications to the personalization of anticancer treatments. Beyond this, FFTC represents a major breakthrough in microfluidics, a technological field that is currently revolutionizing biology and medicine. Currently its democratization and societal impact are limited by fabrication costs. FFTC will overcome this barrier. COMMiT will thus pave the route to a wide range of other applications, such as “point-of-care” devices or “organs-on-chip” to replace animal testing.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COMMIT" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "COMMIT" are provided by the European Opendata Portal: CORDIS opendata.
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AllergenDetect (2019)
Comprehensive allergen detection using synthetic DNA libraries
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