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COMMiT SIGNED

Cancer Organoids Multiplexed Screening in Microfluidic Textile chips

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 COMMiT project word cloud

Explore the words cloud of the COMMiT project. It provides you a very rough idea of what is the project "COMMiT" about.

diagnosis    route    breakthrough    chip    spheroids    assay    models    personalization    droplets    generate    prepare    panels    affordable    screen    3d    organs    fftc    proving    cello    textile    trials    societal    individual    biology    world    turn    laboratories    leads    point    content    democratization    minute    1000    precision    treatments    chips    context    first    treatment    biopsy    explosion    anticancer    tumor    fabrication    animal    throughput    tested    calls    samples    replace    micro    limited    barrier    care    microfluidic    microfluidics    nanoliter    reduce    ercadg    drug    screening    invented    encapsulated    versus    resolution    automated    solution    consumption    notably    cancer    power    pharmaceutical    free    cell    revolutionizing    flow    time    ranging    single    medicine    pave    platform    commit    conventional    market    drugs    overcome    technological    techniques    industrialization    industry    size    tens    clinical    personalized    combinations    paradigm   

Project "COMMiT" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 150˙000.00

Map

 Project objective

The development of precision and personalized medicine, notably in cancer, leads to an explosion in the cost of research, clinical trials, diagnosis and treatment. It calls for a change of paradigm in cell-based personalized models, allowing-high throughput screening of large panels of drugs at low cost and on minute samples. We invented in ERCadg CellO a new technology “Free-Flow Textile Chips” (FFTC) proving a solution to the above problem. It allows the production of high-resolution complex microfluidic devices at very low cost using the power of the textile industry. Using this technology we developed an automated platform able to generate, from a single micro-biopsy, a large number of 3D tumor cell spheroids encapsulated within individual nanoliter droplets, and to screen them against tens of drug combinations. This platform will reduce the time, sample size, cost of screening and drugs consumption per assay by factors ranging from 10 to 1000. This will in turn replace animal testing, and allow low-cost high-content drug screening and affordable precision medicine. This new platform will be tested versus conventional techniques in a real world context, and steps towards industrialization will be taken. We shall first target the market of research laboratories and drug development in the pharmaceutical industry, but also prepare clinical applications to the personalization of anticancer treatments. Beyond this, FFTC represents a major breakthrough in microfluidics, a technological field that is currently revolutionizing biology and medicine. Currently its democratization and societal impact are limited by fabrication costs. FFTC will overcome this barrier. COMMiT will thus pave the route to a wide range of other applications, such as “point-of-care” devices or “organs-on-chip” to replace animal testing.

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The information about "COMMIT" are provided by the European Opendata Portal: CORDIS opendata.

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