BIONANOMUTT

Multi-compartmental Biomolecular Nanocarriers for Multi-modal Targeted Therapies

Coordinatore	UNIVERSITY OF LEEDS    more  Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT contact info Titolo: Mr. Nome: Martin Cognome: Hamilton Email: send email Telefono: +44 113 343 4090 Fax: +44 113 343 4058
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-01   -   2015-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF LEEDS  Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT contact info Titolo: Mr. Nome: Martin Cognome: Hamilton Email: send email Telefono: +44 113 343 4090 Fax: +44 113 343 4058	UK (LEEDS)	coordinator	100˙000.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Nanomedicine is an interdisciplinary field of research that aims to use nanotechnology to improve the pharmacokinetic profile of therapeutics and/or the contrast and information from medical imaging and diagnostics. The advances in medical treatments that nanomedicine strategies will provide will have a significant socioeconomic impact for the E.U. and is particularly timely due to the aging populations in E.U. member states. This work will use a multi-strategy approach to design novel multicompartmental, multifunctional nanoarchitectures for nanomedicine applications. Lipid nanodiscs will be evaluated as a novel hydrophobic drug carrier and the versatility of the scaffold protein for these discs will be explored by assessing its capacity to form similar complexes with synthetic block copolymers. Multicompartmental, size-limited nanostructures will be developed by using the self-organisation of functional amphiphiles into anisotropic subunits as building blocks for superstructures of greater complexity and functionality. The basic building blocks explored will consist of liposomes, polymersomes and hydrid lipopolymersome structures as well as protein-stabilised lipid nanodiscs. This project will also explore incorporating quantum dots into these nanoarchitectures as an added imaging modality. Finally, through multidisciplinary collaboration of basic scientists through to clinicians, an adjuvant nanomedicine therapy will be developed for treatment of superficial bladder cancers. These therapeutic nanoparticles will contain therapeutic, imaging and active targeting functionalities to remove residual malignant cells following the surgical resection of tumours.'