ANT

Mining for new antimicrobials in ant associated actinomycetes

Coordinatore	THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS    more  Organization address address: NORTH STREET 66 COLLEGE GATE city: ST ANDREWS FIFE postcode: KY16 9AJ contact info Titolo: Ms. Nome: Trish Cognome: Starrs Email: send email Telefono: +44 1334 467286 Fax: +44 1334 462217
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	210˙092 €
EC contributo	210˙092 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IIF
Funding Scheme	MC-IIF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-10-05   -   2014-02-05

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS  Organization address address: NORTH STREET 66 COLLEGE GATE city: ST ANDREWS FIFE postcode: KY16 9AJ contact info Titolo: Ms. Nome: Trish Cognome: Starrs Email: send email Telefono: +44 1334 467286 Fax: +44 1334 462217	UK (ST ANDREWS FIFE)	coordinator	105˙046.40
2	UNIVERSITY OF EAST ANGLIA  Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ contact info Titolo: Ms. Nome: Sandra Cognome: Hall Email: send email Telefono: +44 1603 593216	UK (NORWICH)	participant	105˙046.40

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 Obiettivo del progetto (Objective)

The proposed research is multidisciplinary and involves using state-of-the-art technologies (combined genomic and metabolomic approaches) to discover new antifungal compounds from an untapped environmental niche that the groups of Goss and Hutchings are currently mining. Novel methodologies developed by Dr Gao within Professor Lixin Zhang’s group will be utilized to rapidly mine the ant associated microbes for novel bioactive natural products and to engineer enhanced levels of antibiotic and antifungal production. Synergic interactions of the antibiotics will be explored using high through put assays developed by Dr Gao and Professor Zhang

Introduzione (Teaser)

Infectious diseases are a leading cause of death worldwide, necessitating the urgent discovery of new antimicrobial and anti-fungal agents. By exploiting genomic technologies, European researchers disclosed a series of natural compounds present in ant-associated bacteria.