HND
Mechanisms of Human Neuronal Development and Functional Integration in Neural Network
| Coordinatore | UNIVERSITE D'AIX MARSEILLE
Organization address
address: Boulevard Charles Livon 58 contact info |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 232˙676 € |
| EC contributo | 232˙676 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-IOF |
| Funding Scheme | MC-IOF |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-05-01 - 2015-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITE D'AIX MARSEILLE
Organization address
address: Boulevard Charles Livon 58 contact info |
FR (Marseille) | coordinator | 232˙676.80 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
Despite the exponentially growing burden that neurodevelopment or neurodegenerative diseases represent in public health, the therapies are mostly inexistent or very limited. Intensive fundamental research on the biological mechanisms of neurological disorders is strongly needed to discover and validate pharmacological treatments. At the same time, there is a pressing need for treatment that would compensate the loss of neurons occurring in a multitude of neurological disorders. Rare clinical trials have promoted the feasibility of stem cell-based therapy in the human brain. However, when significant, the benefits of the treatment were transient, and did not completely stop the progression of the disease. Unfortunately, the physiological causes of success or failure of the grafts remain unclear. It seems thus crucial to develop new human experimental models to resolve those issues. In this context, the HND proposal is guided by the objective to study the key mechanisms of human neuronal development and more precisely to clarify how human neural progenitors may functionally integrate neural networks. To reach this aim, I will have to achieve the following specific objectives: 1) Developing human experimental neuron-based models, and 2) Developing new strategies to insure the appropriate maturation, integration, function and fate of neural progenitors. The HND project will be performed on neural cell culture obtained from human tissue, by using state-of-the-art genetic reprogramming techniques. The originality of the proposal is to combine several cutting-edge genetic and physiological technologies to approach the topic at cellular and neural network levels in living tissue. The outcomes of the project will be particularly important to research aiming to identify the biological mechanisms underlying neurological pathologies and validate pharmacological treatments, as well as to restorative cell therapies.