RHINOSPEC

Dissecting speciation using a genomics approach

Coordinatore	EAST CHINA NORMAL UNIVERSITY ECNU    more  Organization address address: NORTH ZHONGSHAN ROAD 3663 city: SHANGHAI postcode: 200062 contact info Titolo: Mr. Nome: Shuyi Cognome: Zhang Email: send email Telefono: +86 021 62235786 Fax: +86 021 62235786
Nazionalità Coordinatore	China [CN]
Totale costo	15˙000 €
EC contributo	15˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IIF
Funding Scheme	MC-IIFR
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-04-14   -   2015-04-13

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	EAST CHINA NORMAL UNIVERSITY ECNU  Organization address address: NORTH ZHONGSHAN ROAD 3663 city: SHANGHAI postcode: 200062 contact info Titolo: Mr. Nome: Shuyi Cognome: Zhang Email: send email Telefono: +86 021 62235786 Fax: +86 021 62235786	CN (SHANGHAI)	coordinator	15˙000.00

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 Obiettivo del progetto (Objective)

'Our proposal will tackle a central issue in biology: what is the genetic basis of species differentiation? Recent evidence of genetic exchange among species has led many to reject the traditional view that speciation requires complete reproductive isolation. Instead, the emerging new concept of so-called ‘genic speciation’ asserts that reproductive barriers can be established by divergence at only a few loci against a background of gene flow. We will combine novel and powerful analytical methods with new and traditional genetic technologies to investigate the genetic basis of species differences, and the process of divergence, in a model system of two co-distributed species of horseshoe bat (R. yunanensis and R. p. pearsoni). The Incoming Fellow has previously shown that, in these taxa, there is strong evidence of extensive past replacement of the nuclear genome in spite of clear phenotypic, acoustic and karyotypic differences. This unusual system provides an exceptional opportunity to identify and characterize genes that encode phenotypic differences among taxa, and also to determine the functional characteristics of ‘leaky genes’ versus ‘non-leaky genes’ (or ‘species genes’). Such knowledge of a natural mammalian system at a genome scale would take us beyond the current state-of-the art of research in this field, and would have impact in frontier science as well as potential benefits to conservation, genetics and evolutionary biologists. We will use Next Generation Sequencing and a highly novel statistical pipeline to identify key loci and larger ‘genomic islands’ that have resisted introgressive hybridization between our focal taxa. Our phylogenomic approach will then be extended to a larger sample to study whether these loci are under selection. Finally, we will apply chromosomal genetics methods to establish whether non-leaky loci and islands are influenced by the presence of chromosomal rearrangements, such as inversions.'