RBC MIRNA

The role of microRNAs in the Retinal Bipolar Cell

Coordinatore	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH    more  Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 contact info Titolo: Ms. Nome: Dorothy Cognome: Searles Email: send email Telefono: 41616972982 Fax: 41616973976
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	192˙622 €
EC contributo	192˙622 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IIF
Funding Scheme	MC-IIF
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-02-01   -   2015-06-06

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH  Organization address address: MAULBEERSTRASSE 66 city: BASEL postcode: 4058 contact info Titolo: Ms. Nome: Dorothy Cognome: Searles Email: send email Telefono: 41616972982 Fax: 41616973976	CH (BASEL)	coordinator	192˙622.20
2	Novartis Forschungsstiftung  Organization address address: Maulbeerstrasse 66 city: BASEL postcode: 4058 contact info Titolo: Ms. Nome: Dorothy Cognome: Searles Email: send email Telefono: +41 61 6972982 Fax: +41 61 6973976	CH (BASEL)	participant	0.00

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 Obiettivo del progetto (Objective)

Studies conducted at the Friedrich Meischer Institute (FMI) in Basel have focused on the roles of miRNAs specific to the retina. They have recently shown that absence of functional miRNA expression has severe consequences on mature cone photoreceptors of the mouse retina; a selective and dramatic reduction of cone-specific gene expression arises with the cone-specific loss of regulation by miRNAs in adult mice. The bipolar cells act post-synaptically to the photoreceptors where they not only transmit but also process the light signal received from rods and cones. In this proposal I wish to examine whether absence of functional miRNAs have as severe implications for the bipolar cells as they do for cone photoreceptors. In addition by profiling the miRNA population of these highly specialised neurons I hope to uncover miRNA/mRNA interactions that can fine-tune synaptic transmission and thus contribute to visual processing.