MIC-SN

Microbial Ion Channels for Synthetic Neurobiology

 Coordinatore Institute of Science and Technology Austria 

 Organization address address: Am Campus 1
city: Klosterneuburg
postcode: 3400

contact info
Titolo: Ms.
Nome: Willetta
Cognome: Barnhill
Email: send email
Telefono: +43 2243 9000 1051

 Nazionalità Coordinatore Austria [AT]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-03-01   -   2016-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Institute of Science and Technology Austria

 Organization address address: Am Campus 1
city: Klosterneuburg
postcode: 3400

contact info
Titolo: Ms.
Nome: Willetta
Cognome: Barnhill
Email: send email
Telefono: +43 2243 9000 1051

AT (Klosterneuburg) coordinator 100˙000.00

Mappa

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signalling    first    microbial    lgics      

 Obiettivo del progetto (Objective)

'The goal of this project is to control signalling in the mammalian nervous system with ‘hi-jacked’ microbial receptor proteins. We will first compile a comprehensive library of microbial ligand-gated ion channels (m-LGICs), and we will then characterize the function of selected m-LGICs in molecular detail. In order to exploit the technological potential of m-LGICs, we will employ them to control signalling in a model of epilepsy. This project provides the first systematic characterization of m-LGIC diversity and the first application thereof for the re-engineering of biological systems. It will develop the orthogonal manipulation of neuronal electrical signals with potential for treating neurological diseases. It will also open the door to new agents that target microbes threatening health and agriculture. The applicant Harald Janovjak from the University of California Berkeley has taken up a five-year post at the Institute of Science and Technology Austria. He will receive project support, mentoring and career development to build up an independent research group, supervise students and maintain international collaborations. His background brings new research opportunities to Europe and seamlessly integrates with research at the host institution.'

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