FISHIL10

Host and viral Interleukin-10 in fish: evolution of a regulatory cytokine

Coordinatore	WAGENINGEN UNIVERSITY    more  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Dr. Nome: Geert Cognome: Wiegertjes Email: send email Telefono: 31317482732 Fax: 31317483955
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	183˙805 €
EC contributo	183˙805 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-05-01   -   2014-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	WAGENINGEN UNIVERSITY  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Dr. Nome: Geert Cognome: Wiegertjes Email: send email Telefono: 31317482732 Fax: 31317483955	NL (WAGENINGEN)	coordinator	183˙805.80

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 Obiettivo del progetto (Objective)

'Interleukin (IL)-10 is a cytokine that, at least in mammals, plays a central role in innate and adaptive immunity. IL-10 limits inflammation by acting on macrophages and promotes anti-inflammatory responses via T-helper cells. Underlining the regulatory role of IL-10 is the presence of IL-10 homologues in viral genomes (vIL-10). IL-10 has been cloned in several fish species but only recently a vIL-10 has been identified in the genome of koi-herpes-virus (KHV), a highly pathogenic virus of carp. Very little is known about the function of fish IL-10 and nothing is known about the activity of khvIL-10. However, the presence of this cytokine in both fish and their viruses, suggests a conservation of function throughout the vertebrate lineage. The first aim is to identify IL-10-producing leukocytes in carp. The second aim is to study the effect(s) of carp and KHV IL-10 on different leukocytes, in vitro. The third aim is to investigate the immunomodulatory effect(s) of carp and KHV IL-10 in vivo during a natural infection of carp. The overall aim is to investigate the biological activity of both host and viral IL-10 in fish to study the evolutionary conservation of function of this important regulatory cytokine.'