SMOOS

SMOC2 in osteoarthritis

Coordinatore	KATHOLIEKE UNIVERSITEIT LEUVEN    more  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Stijn Cognome: Delauré Email: send email Telefono: +32 16 320 944 Fax: +32 16 324 198
Nazionalità Coordinatore	Belgium [BE]
Totale costo	169˙800 €
EC contributo	169˙800 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-05-01   -   2014-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Stijn Cognome: Delauré Email: send email Telefono: +32 16 320 944 Fax: +32 16 324 198	BE (LEUVEN)	coordinator	169˙800.00

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 Obiettivo del progetto (Objective)

'This project will study the role of SMOC2 in the biology and pathology of synovial joints with specific attention towards osteoarthritis (OA), one of the most common chronic diseases. SMOC2 is a novel secreted protein that can interact with bone morphogenetic protein (BMP) and Wingless-like (Wnt) signaling key pathways in joint development, homeostasis, disease and repair. We will use a translational research approach combining in vitro data with mechanistic insights obtained in a well characterized animal model and then linking this to ex vivo patient data. In addition, SMOC2 and modified versions of the protein will be specifically tested for therapeutic applications. If successful, this project will teach us how SMOC2 interacts with BMP and Wnts in joint biology and disease. The aim is to define SMOC2 biology as a therapeutic target to improve diagnosis, treatment and prognosis of osteoarthritis. Dr. Cailotto, the experience researcher candidate for the fellowship, will be trained in the use of animal models and dealing with translational research hypotheses. He will also benefit from complementary skills training and interactions with industry in order to gain further maturity and independence as a researcher. This additional training will be beneficial to his career as well as to the European Research Area as there is a great societal need for translational researcher in the field of chronic joint diseases able to make links between basic biology and clinical questions. The project pays specific attention to cross-sectorial interactions and communication with the scientific community as well as with the primary stakeholders for osteoarthritis: the patients and population at risk.'

Introduzione (Teaser)

European researchers put the pathology of osteoarthritis (OA) under the microscope to identify new therapeutic targets. The outcome of the study will hopefully improve OA diagnosis, treatment and prognosis.