EMP-ECM

Towards Engineered Multicomponent Polysaccharide Hydrogels for Surrogate Extracellular Matrices

 Coordinatore BEN-GURION UNIVERSITY OF THE NEGEV 

 Organization address address: Office of the President - Main Campus
city: BEER SHEVA
postcode: 84105

contact info
Titolo: Ms.
Nome: Daphna
Cognome: Tripto
Email: send email
Telefono: +972 8 6472435
Fax: +972 8 6472930

 Nazionalità Coordinatore Israel [IL]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-03-01   -   2016-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    BEN-GURION UNIVERSITY OF THE NEGEV

 Organization address address: Office of the President - Main Campus
city: BEER SHEVA
postcode: 84105

contact info
Titolo: Ms.
Nome: Daphna
Cognome: Tripto
Email: send email
Telefono: +972 8 6472435
Fax: +972 8 6472930

IL (BEER SHEVA) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cellular    mechanical    effect    polysaccharide    relations    polymers    molecules    engineering    systematic    peptides    hierarchical    peptide    bioactive    function    hydrogels    synthetic    ing    structure   

 Obiettivo del progetto (Objective)

'Current effort in the engineering of synthetic extracellular matrixes has focused on installing molecular features (peptides, proteins and bio-interactive polymers) within insoluble scaffolds, either by self-assembly or through covalent modifications of polymer or biopolymer networks. Apart from their direct role in cell interaction, bioactive molecules or peptide sequences affect the hierarchical structural organization and mechanical properties of the resulting material, thus indirectly affecting the cellular response. The overall aim of the proposed research is to develop a fundamental understanding of the structure-mechanical properties-function relations of multicomponent polysaccharide hydrogels used in tissue engineering applications and to apply this understanding in the development of engineering principles that can serve as a generic guide for the design of polysaccharide-based materials for biological applications. Three specific aims will be addressed: 1) Characterization of the interrelations between the chemical compositions of the building blocks (both polymers and peptides) and the resulting structure of the bioactive gels; 2) Systematic investigation of the effect of the different structures on the physical properties of the hydrogel constructs; and 3) Evaluation of the cellular response of the synthesized hydrogels. A methodical study correlating the effect of the bioactive molecules on the resulting hierarchical structure (explored by small angle scattering) and consequent properties will be performed to elucidate the synergetic interactions among the components that determine scaffold effectiveness. A systematic exploration of the polysaccharide type, method of peptide incorporation and gelling parameters will reveal the key factors involved in structure-function relations of the synthetic ECMs. These factors will be employed to create general guidelines for the design of multi-component polysaccharide hydrogels for desired applications.'

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