INFO

Organoids as infection model

Coordinatore	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW    more  Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV contact info Nome: Don Cognome: Van Velzen Email: send email Telefono: +31 30 2121800 Fax: +31 30 2516464
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	183˙805 €
EC contributo	183˙805 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-IEF
Funding Scheme	MC-IEF
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-04-01   -   2014-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW  Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV contact info Nome: Don Cognome: Van Velzen Email: send email Telefono: +31 30 2121800 Fax: +31 30 2516464	NL (AMSTERDAM)	coordinator	183˙805.80

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 Obiettivo del progetto (Objective)

'The mucosal surfaces of the human stomach and gut are in constant contact with bacteria and viruses. This encompasses the often mutually beneficial relationships with commensals as well as encounters with pathogens. The study of host-microbe interactions is hampered by a lack of suitable model systems: many bacteria or viruses cannot be cultured or existing models do not sufficiently recount the human disease. This project aims at the development of new in vitro models and the subsequent characterization of the host response to three microorganisms: the carcinogenic bacterium Helicobacter pylori, the most common cause for non-bacterial gastroenteritis, Norovirus, and the commensal Small Filamentous Bacteria. A culture system that was recently developed in lab of Dr. Clevers will be used in which adult stem cells give rise to three-dimensional structures (‘organoids’) resembling mature, polarized epithelium of the stomach, small intestine and colon.'