SELF-TOLERANCE

"Generating self-antigen diversity in the thymus: from gene expression patterns in single cells to the system level, an integrative approach"

 Coordinatore DEUTSCHES KREBSFORSCHUNGSZENTRUM 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 2˙014˙560 €
 EC contributo 2˙014˙560 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-ADG_20110310
 Funding Scheme ERC-AG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-06-01   -   2017-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Prof.
Nome: Bruno Anton
Cognome: Kyewski
Email: send email
Telefono: +49 6221 423734
Fax: -429909

DE (HEIDELBERG) hostInstitution 2˙014˙560.00
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Prof.
Nome: Ina
Cognome: Krischek
Email: send email
Telefono: +49 6221 422700
Fax: +49 6221 422708

DE (HEIDELBERG) hostInstitution 2˙014˙560.00

Mappa


 Word cloud

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autoimmune    receptor    molecular    biology    cell    cells    tras    epigenetic    pge    expression    immune    generation    antigens    self    tolerance    principles    repertoire    relation    tecs    thymic   

 Obiettivo del progetto (Objective)

'The thymus plays a central role in the induction of self-tolerance, a hallmark of the immune system. During T cell development a highly diverse T cell receptor repertoire is probed against a matching array of self-antigens. While the generation of the T cell receptor repertoire relies on unique genetic recombination mechanisms, the corresponding molecular principles underlying the generation of TCR ligands - self-peptide/MHC complexes - are less well understood; recent data indicate that novel principles of epigenetic control are employed. This proposal aims at understanding a unique feature of thymic epithelial cells (TECs), namely the expression of a multitude of tissue-restricted antigens (TRAs), a phenomenon termed promiscuous gene expression (pGE) in the context of self-tolerance. The integrative approach of this proposal has 4 main objectives (i) a characterization of the molecular control of different pools of pGE beyond the role of the Autoimmune Regulator (Aire) in relation to the developmental biology of TECs (ii) a comprehensive and comparative analysis of expression patterns of TRAs in single cells of different species in relation to epigenetic signatures and higher chromatin order, (iii) translating these findings to the cellular dynamics and topology of the thymic medullary compartment, e.g. individual mTEC clones in situ (iv) the modelling of these different levels of analysis by a system biology approach, e.g. testing our hypothesis that clusters of TRAs in the genome represent an “operational unit” of pGE. We expect from these studies new basic insights into a fascinating and still arcane aspect of the vertebrate immune system, which will also contribute to our understanding of the etiology and pathophysiology of human autoimmune diseases.'

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FLEXABLE (2013)

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CARNOMORPH (2013)

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