NADETOX

NAnomics in vitro DEvelopmental TOXcology

 Coordinatore TECHNISCHE UNIVERSITEIT DELFT 

 Organization address address: Stevinweg 1
city: DELFT
postcode: 2628 CN

contact info
Titolo: Mrs.
Nome: Karin
Cognome: Graaf Van Der
Email: send email
Telefono: +31 15 2781773

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 183˙805 €
 EC contributo 183˙805 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-10-19   -   2014-10-18

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT

 Organization address address: Stevinweg 1
city: DELFT
postcode: 2628 CN

contact info
Titolo: Mrs.
Nome: Karin
Cognome: Graaf Van Der
Email: send email
Telefono: +31 15 2781773

NL (DELFT) coordinator 183˙805.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

dna    embryo    stability    environment    nadetox    metallic    fetax    nanoparticles    assay    medium    xenopus    nps   

 Obiettivo del progetto (Objective)

'The progress made in improving the development and the production of nanoparticles (NPs) is enormous. Metallic nanoparticles (mNPs) are among the most widely used types of NPs in electronics, foods, containers, pharmaceutical drugs, cosmetics and paints. This trend will lead to an ever-increasing presence of NPs in the environment. This scenario means that humans and the environment will be exposed to more and more nanotechnology-based products whose health risks and environmental impacts of NPs might outweigh their benefits. In order to promote prevention and safety in manufacturing and handling of NPs, NADETOX aims at evaluating the nanodevelopmental toxicity of selected metallic cobalt, silver and gold NPs extensively used in nanomedicine for cancer therapy. This novel and multidisciplinary research project is based on the 3Rs in vitro approach (Reduction, Refinement, Replacement), involving the development of a mechanistically-based alternative method, Frog Embryo Teratogenesis Assay-Xenopus (FETAX), and the combined use of peculiar advanced spectrochemical, radioanalytical, biochemical and molecular biology techniques. These methods offer the opportunity to label NPs, avoiding surface modification, to localise and quantify them in organisms. NADETOX aims at the following goals: (i) characterisation of NPs establishing their size and morphology, (ii) study of stability and of the eventual release of metal ions from radiolabelled NPs in the reconstituted water medium suitable for the culture of Xenopus embryos (FETAX medium), (iii) evaluation of embryolethality and teratogenicity of NPs by FETAX assay, (iv) biokinetics studies to measure uptake, metabolic fate and biopersistence of NPs in Xenopus at embryo and larva stages and structure diagnosis at DNA level, to get information on the genomic stability following formation of DNA-adducts.'

Altri progetti dello stesso programma (FP7-PEOPLE)

OXY-SENSE (2009)

"OXY-SENSE - A biosensor, image analysis, and work flow system platform for the study of neuronal injury and assessment of cellular bioenergetics"

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CORPA (2015)

COgnitive Radio Platform and Algorithms

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ROOTS (2013)

The roots of plant productivity: how the rhizosphere interact with the aboveground armament for indirect and direct defense against abiotic stressors

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