BIOCHEMICAL IMAGING
Fatty acid processing and metabolism in muscle cells revealed by non-linear vibrational imaging
| Coordinatore | MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 100˙000 € |
| EC contributo | 100˙000 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2012-CIG |
| Funding Scheme | MC-CIG |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-08-01 - 2016-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | coordinator | 100˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'Fatty acid (FA) intake and its subsequent fate are implicated the two most prevalent diseases in the developed world, coronary heart disease and type 2 insulin-resistant diabetes. More than 300 million people world-wide live with type 2 diabetes, and its incidence is increasing rapidly, especially in developing countries. In Europe alone, direct medical expenses for type 2 diabetes totals more than 30 Billion € per year and more than 50% of these costs are related to hospitalization. This Career Integration Grant application outlines the PI’s research programme to use a non-linear vibrational imaging technique in order to explore the underlying FA dynamics during ectopic fat deposition and FA metabolism in muscle cells.
Ectopic fat appears in muscle of insulin-resistant, type 2 diabetics and also, paradoxically, in endurance trained athletes – who have acute insulin sensitivity. The methods developed in this proposal will provide a platform for answering many unresolved questions regarding FA dynamics in muscle cells from intake (and lipogenesis) to FA metabolism in both normal and insulin-resistant muscle cells. The scientific results gleaned from this research will provide new data about FA packaging into LDs and FA metabolism upon triggered lipolysis as a function of insulin activity levels. Furthermore, experiments investigating LD proximity to mitochondria in normal and insulin-resistant muscle cells will provide much needed data to help unravel the “athletes paradox” outlined above. The outcome of the PI’s research plan will reveal a link between FA processing and insulin resistance, which is critical for design of new therapeutics to treat type 2 diabetes.'