PREN-IBD

Influence of protein prenylation and its modulation on the immune system

 Coordinatore UNIVERSITATSKLINIKUM ERLANGEN 

 Organization address address: Maximiliansplatz 2
city: ERLANGEN
postcode: 91054

contact info
Titolo: Dr.
Nome: Katrin
Cognome: Faber
Email: send email
Telefono: +49 9131 8546753
Fax: +49 9131 8535903

 Nazionalità Coordinatore Germany [DE]
 Totale costo 167˙390 €
 EC contributo 167˙390 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-08-01   -   2014-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM ERLANGEN

 Organization address address: Maximiliansplatz 2
city: ERLANGEN
postcode: 91054

contact info
Titolo: Dr.
Nome: Katrin
Cognome: Faber
Email: send email
Telefono: +49 9131 8546753
Fax: +49 9131 8535903

DE (ERLANGEN) coordinator 167˙390.40

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

biology    differentiation    biological    function    proteins    expression    deletion    cd    cre    cell    mice    ggtasei    prenylation    related    types    immune    cytoskeletal    cells    epithelial    models    protein   

 Obiettivo del progetto (Objective)

'Prenylation is a postranslational process leading to changes in protein structure due to the incorporation of a lipidic moiety that significantly modifies their physicochemical properties and their behaviour. Prenylation is therefore a crucial step for key cell processes, such as interaction between proteins, cell and differentiation, cytoskeletal function and vesicular trafficking. The modification of prenylation is proposed as an attractive option in biological and therapeutic research, as its alteration can cause significant changes in cell biology. In fact, several prenylation inhibitors are currently included in preclinical and clinical research as anticancer agents (Sasaki M, 2003; Mach F, 2002). Many prenylation-modified processes can be considered of immune or inflammatory nature. In addition, a major substrate for prenylation reactions are small G proteins, which are involved in the activation of some relevant signaling pathways in the immune system. Thus, the immune response could be controlled by modulating prenylation. Specific cell-type inhibition of prenylation could be interesting allowing a better knowledge of its implication in cell biology considering several cell types related to the immune response. A novel technique for in vivo experiment is the genetic design of animals suffering from a cell-specific deficiency in the expression of a particular protein. This project is intended to study the influence of the lack of expression of one of the major enzymes involved in prenylation, GGTaseI, specifically in several cell types related to immune response, such as intestinal epithelial cells or lymphocytes. We will create strains by crossing Pggt1b-flox mice (Sjogren AK, 2007) with Villino-Cre mice (deletion of GGTaseI in epithelial cells) or with CD4-Cre mice (deletion of GGTaseI in CD4 T cells) and do analysis of the evolution of these mice after several models of inflammation-associated colon cancer (AOM / DSS model) or in colitis models.'

Introduzione (Teaser)

Prenylation, post-translational modifications of proteins are essential for a number of biological processes, including cytoskeletal function and cell differentiation. Emerging evidence implicates these protein structural changes in disease development

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