INSANE IN A MEMBRANE

The origin and function of CD20 positive T-cells in health and disease

 Coordinatore THE UNIVERSITY OF EXETER 

 Organization address address: Northcote House, The Queen's Drive
city: EXETER
postcode: EX4 4QJ

contact info
Titolo: Ms.
Nome: Gaynor
Cognome: Hughes
Email: send email
Telefono: +44 1392 725835
Fax: +44 1392 263686

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 104˙516 €
 EC contributo 104˙516 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IEF
 Funding Scheme MC-IEF
 Anno di inizio 0
 Periodo (anno-mese-giorno) 0000-00-00   -   0000-00-00

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER

 Organization address address: Northcote House, The Queen's Drive
city: EXETER
postcode: EX4 4QJ

contact info
Titolo: Ms.
Nome: Gaynor
Cognome: Hughes
Email: send email
Telefono: +44 1392 725835
Fax: +44 1392 263686

UK (EXETER) coordinator 104˙516.70

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    ra    cells    progression    oc    preliminary    cd    immune    patients    pathogenesis    data    cancer    determine    tem    population    auto   

 Obiettivo del progetto (Objective)

'The expression of CD20 is generally assumed to be restricted to lymphocytes of the B-cell lineage. However, there is accumulating evidence that a small subpopulation of T-cells also express CD20. These CD20 T-cells, which might be described as “insane in their membrane”, were first reported in 1993. The role of these cells in the immune system, however, has never been addressed. The preliminary data presented in the current proposal indicates that the vast majority of these CD20 T-cells are in fact effector memory T-cells (TEM). Moreover, preliminary data implicate these CD20 TEM cells in the pathogenesis of Rheumatoid Arthritis (RA) and Ovarian Cancer (OC). In RA patients, these CD20 TEM cells secrete large amounts of the pro-inflammatory cytokine IL-17. In OC patients, CD20 TEM cells account for a striking 20% of all resident T-cells in the peritoneal fluid of patients. Taken together, these findings suggest that CD20 TEM cells may represent a thus far neglected, but important, immune cell population involved in the pathogenesis of major human diseases like auto-immunity and cancer. The aim of the current proposal is to determine the origin and function of CD20 TEM cells in healthy individuals, and determine their involvement in auto-immune and cancer progression. To this end, we will determine the precise phenotype of CD20 TEM cells, their broad antigen-specificity, and changes that occur within this population during RA/OC progression. In addition, we will determine if CD20 T-cells can be induced from naive T-cells. Finally, we will perform preliminary experiments to determine whether CD20 T-cells might be used for cancer immunotherapy, or selectively eliminated for treatment of auto-immune disease.'

Altri progetti dello stesso programma (FP7-PEOPLE)

CELNIC (2012)

Role of gene silencing pathways in C. elegans nicotine dependence

Read More  

4U2NIGHT (2011)

Malopolska Researchers’ Night 2011

Read More  

STSON NANOSTRUCTURES (2009)

Investigation of the electronic properties of nanostructures at the atomic scale by means of low temperature scanning tunneling microscopy/spectroscopy in ultrahigh vacuum conditions

Read More