MASPGREEN

Mechanically-Assisted Synthesis of Pharmaceuticals: A Greener Energy Input

 Coordinatore THE MANCHESTER METROPOLITAN UNIVERSITY 

 Organization address address: All Saints Building Oxford Road
city: MANCHESTER
postcode: M15 6BH

contact info
Titolo: Dr.
Nome: Margaret
Cognome: Eastcott
Email: send email
Telefono: 441612000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-05-01   -   2017-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE MANCHESTER METROPOLITAN UNIVERSITY

 Organization address address: All Saints Building Oxford Road
city: MANCHESTER
postcode: M15 6BH

contact info
Titolo: Dr.
Nome: Margaret
Cognome: Eastcott
Email: send email
Telefono: 441612000000

UK (MANCHESTER) coordinator 100˙000.00

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Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

chemistry    synthesis    chemical    synthetic    pharmaceutical    sustainable    transformation    organic    mechanochemistry   

 Obiettivo del progetto (Objective)

'In a world with increasing population and limited resources, the development of new synthetic procedures will not only be judged by their yield and/or product selectivity, but also by their ecological and economical footprint. Mechanochemistry is a branch of sustainable chemistry which involves a rapid and clean way to transfer the energy needed for the chemical transformation, using friction, via either ball-milling or grinding. In this project, we intend to exploit the attractive practical advantages and opportunities that mechanochemistry offers for the development of the sustainable synthesis of complex pharmaceutical products. In particular, the research focuses on the study of a collection of the most useful tools in organic chemistry: alkylation, condensation, addition, cycloaddition and hydrogenation reactions, in both their racemic and enantioselective version. The development, optimisation and assessment of these transformations will be performed using the biologically active barbiturates as synthetic scaffolds. Moreover, through the study and determination of the key kinetic and thermodynamic parameters for the optimised mechanochemical process, and by means of computational chemistry, we will develop and validate a robust predictive model for these kinds of transformation.

This project provides a strong foundation for an innovative network that integrates organic, pharmaceutical, analytical and physical chemistry in the common pursuit of becoming greener. This research aims for a cleaner and more efficient synthesis of pharmaceuticals whilst gaining a better understanding of the physico-chemical parameters that govern mechanochemistry. We envisage that this project will open a significant number of new research opportunities in environmentally-friendly synthesis.'

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