HIPPOFRONTALSYN

Hippocampal-prefrontal synaptic transmission in cognitive function

Coordinatore	WEIZMANN INSTITUTE OF SCIENCE    more  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Gabi Cognome: Bernstein Email: send email Telefono: +972 8 934 4026
Nazionalità Coordinatore	Israel [IL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-08-01   -   2016-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Gabi Cognome: Bernstein Email: send email Telefono: +972 8 934 4026	IL (REHOVOT)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Neural circuitry underlies human behavior in all of its forms. High-level ‘Executive’ regions such as the prefrontal cortex (PFC) are the subject of particular interest as functional imaging, electrophysiological, and post-mortem studies have shown cellular and neurophysiological abnormalities in these regions associated with psychiatric disorders (e.g. schizophrenia, mood disorders, and addiction). The prefrontal cortex is one of the most highly interconnected regions of the brain, integrating inputs from widespread cortical and subcortical regions and transmitting information to an equally diverse set of targets. Major sources of synaptic input into the PFC include the thalamus and the hippocampus, which convey sensory, contextual and spatial information to be processed in the PFC and guide decision making and goal-directed behavior. A direct synaptic connection between the ventral hippocampus and the prefrontal cortex has been proposed to subserve the synchronization of activity between these two regions in defined behavioral states. Recent studies have indicated that the organization of PFC neurons that receive direct hippocampal input might support the entrainment of PFC activity to hippocampal theta oscillations. The goal of this proposal is to identify the prefrontal neuron population which receives direct hippocampal input and test the contribution of these neurons to cognitive processing and emotional states. Using an innovative combination of imaging approaches, electrophysiology and optogenetic techniques, we will first quantify the functional properties of hippocampal-prefrontal synapses and then examine the effects of neuromodulation on the properties of these synapses. Finally, through trans-synaptic labeling we will directly manipulate the activity of cells receiving monosynaptic hippocampal input and test the hypothesis that hippocampal-prefrontal theta phase-locking plays an important role in cognitive processing.'