ECOPOD

Environmentally Controlled Polymorphism of non-B DNA structures

 Coordinatore Masarykova univerzita 

 Organization address address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177

contact info
Titolo: Mrs.
Nome: Veronika
Cognome: Papouskova
Email: send email
Telefono: 420549000000

 Nazionalità Coordinatore Czech Republic [CZ]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-10-01   -   2016-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Masarykova univerzita

 Organization address address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177

contact info
Titolo: Mrs.
Nome: Veronika
Cognome: Papouskova
Email: send email
Telefono: 420549000000

CZ (BRNO STRED) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

biomedical    chemical    dna    sequences    mechanistic    physical    quadruplexes    regions    structures   

 Obiettivo del progetto (Objective)

'Repetitive blocks of guanine- and cytosine-rich sequences, such as those occurring in centromeric and telomeric DNA regions and promoter regions of protein coding genes, have ability to form G- and C-quadruplex structures, respectively. These non-B DNA structures are involved in more than 40 pathological human conditions including cancer. From a biophysical point of view, a common property to both G- and C-rich sequences is their inherent sensitivity to non-specific, physical-chemical environmental factors promoting their conformational polymorphism. Despite significant effort, motivated by both biological significance and biotechnological and biomedical applications of these non-B DNA motifs, the mechanistic nature of the environmentally induced effects remains poorly understood. The mechanistic insight and revealing of relationships between the DNA sequence and its folding topology in relation to its environment is essential for both rational design of novel nanomaterials and ways for their manipulations as well as for related biomedical applications. In this project, we propose systematic investigations of the influence of non-specific physical-chemical factors on structure of the DNA quadruplexes. In parallel, we propose characterization of these structures under the physiological conditions in vivo using state-of-the-art method of in-cell NMR spectroscopy. The acquired information will help to identify physiologically relevant structures of G- and C-quadruplexes.'

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METALZCOMP (2009)

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