DYNAMAX

"Dynamic axial chirality of tertiary aromatic amides, applications in asymmetric synthesis."

 Coordinatore UNIVERSITE PARIS-SUD 

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Mrs.
Nome: Charlotte
Cognome: Croquet
Email: send email
Telefono: +33 1 69153722
Fax: +331 69155599

 Nazionalità Coordinatore France [FR]
 Totale costo 193˙594 €
 EC contributo 193˙594 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2016-01-20

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Mrs.
Nome: Charlotte
Cognome: Croquet
Email: send email
Telefono: +33 1 69153722
Fax: +331 69155599

FR (ORSAY) coordinator 193˙594.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

tertiary    acid    quaternary    compounds    plans    host    chirality    laboratory    aromatic    alpha    amino    axial    acids    starting    asymmetric    synthesis   

 Obiettivo del progetto (Objective)

'A few years ago, the host laboratory has started a new project based on Memory of Chirality and dynamic axial chirality of tertiary aromatic amides and developed a new asymmetric synthesis of quaternary alpha-amino acids by using only the chirality of starting tertiary alpha-amino acid. The host laboratory is also currently working on the development of a new synthesis of enantioenriched non proteinogenic tertiary alpha-amino acid starting from achiral compounds (glycine and aromatic acid) and based on frozen chirality. The good results obtained encouraged them to pursue in this field. The current project consists in further extensions of these methodologies. This project is a great challenge because it is very original in terms of asymmetric synthesis, and in case of success, it would lead to the achievement of absolute asymmetric synthesis of tertiary alpha-amino acids. First, the projects plans to modify the substrates (to improve if possible the results) and then to extend these methodologies to other electrophiles in order to obtain functionalized quaternary or tertiary alpha-amino acids by aldolisation and conjugate addition. Another extension would be the application to the asymmetric synthesis of biologically active compounds, sphingophungines . Finally, the project plans to use the host laboratory expertise in the synthesis of oxazolidinone with external axial chirality to produce new chiral ligands and use them in asymmetric catalysis.'

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