LiPhos

Living Photonics: Monitoring light propagation through cells

 Coordinatore AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS 

 Organization address address: Serrano 117
city: Madrid
postcode: 28006

contact info
Titolo: Mr.
Nome: Alberto
Cognome: Sereno Alvarez
Email: send email
Telefono: +34 91 566 8852
Fax: +34 91 566 89 13

 Nazionalità Coordinatore Spain [ES]
 Totale costo 4˙175˙431 €
 EC contributo 3˙200˙000 €
 Programma FP7-ICT
Specific Programme "Cooperation": Information and communication technologies
 Code Call FP7-ICT-2011-8
 Funding Scheme CP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-11-01   -   2015-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: Serrano 117
city: Madrid
postcode: 28006

contact info
Titolo: Mr.
Nome: Alberto
Cognome: Sereno Alvarez
Email: send email
Telefono: +34 91 566 8852
Fax: +34 91 566 89 13

ES (Madrid) coordinator 0.00
2    AARHUS UNIVERSITET

 Organization address address: Nordre Ringgade
city: AARHUS C
postcode: 8000

contact info
Titolo: Mr.
Nome: Emil
Cognome: Hornung-Nissen
Email: send email
Telefono: +45 5144 7573

DK (AARHUS C) participant 0.00
3    CELLIX LIMITED

 Organization address address: LONG MILE ROAD UNIT
city: Dublin
postcode: 12

contact info
Titolo: Ms.
Nome: Vivienne
Cognome: WILLIAMS
Email: send email
Telefono: 35314500155
Fax: 35314500158

IE (Dublin) participant 0.00
4    DUBLIN CITY UNIVERSITY

 Organization address address: Glasnevin
city: DUBLIN
postcode: 9

contact info
Titolo: Prof.
Nome: Jens
Cognome: Ducrée
Email: send email
Telefono: +353 1 700 5377
Fax: +353 1 700 7873

IE (DUBLIN) participant 0.00
5    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III

 Organization address address: C/ MELCHIOR FERNANDEZ ALMAGRO
city: MADRID
postcode: 28029

contact info
Titolo: Mrs.
Nome: Luzma
Cognome: García
Email: send email
Telefono: 34914531200

ES (MADRID) participant 0.00
6    IXSCIENT LIMITED

 Organization address address: POPES GROVE
city: TWICKENHAM MIDDLESEX
postcode: TW1 4JX

contact info
Titolo: Mr.
Nome: David
Cognome: WENN
Email: send email
Telefono: +44 7585 606228
Fax: +44 20 8892 7809

UK (TWICKENHAM MIDDLESEX) participant 0.00
7    LIONIX BV

 Organization address address: HALLENWEG
city: ENSCHEDE
postcode: 7522 NH

contact info
Titolo: Mr.
Nome: Erwin
Cognome: Bomert
Email: send email
Telefono: 31532030053

NL (ENSCHEDE) participant 0.00
8    RIJKSUNIVERSITEIT GRONINGEN

 Organization address address: Broerstraat
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Dr.
Nome: Dick
Cognome: Veldhuis
Email: send email
Telefono: 31503634142
Fax: 31503634847

NL (GRONINGEN) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

tool    diseases    culture    waveguide    healthy    spectral    disease    innovative    cvd    light    living    liphos    photonics    diagnosis    diagnose    measuring    cells    cell   

 Obiettivo del progetto (Objective)

LIPHOS is focused on the development of completely innovative biophotonic diagnosis tools, which are for the first time implemented using cells as constituent material. Here, and unlike existing systems, light remains confined in a waveguide whose core is uniquely composed by cells, giving rise to the 'Living photonics' concept. In this context, cells play a two-fold role: i) they form the biomaterial with higher refractive index than the surrounding media, thus defining the waveguide; ii) they are interrogated by the light coupled into them, acting as reporter elements and exhibiting a specific spectral response. The advantage of this configuration is the highly-efficient cell-light interaction, making it possible to diagnose diseases by measuring and comparing their photonic fingerprint (PIN). This key parameter, newly introduced in LIPHOS, consists of the spectral response of the living photonics and includes the different inherent or acquired bands and peaks (scattering, absorbance and/or fluorescence) directly related to the cell culture under study. This is highly specific, since healthy and non-healthy cell cultures present different PINs. This ground-breaking method will give rise to a powerful analytical tool, which could be applied to study and diagnose a disease at cell culture level. The ultimate aim of the LIPHOS project is the diagnosis of cardiovascular diseases (CVD). This target will be addressed firstly by measuring adherent cell layers cultured under controlled conditions and representing disease or healthy states. At a later stage, the LIPHOS concept will undergo pre-clinical validation as a diagnostic tool for CVD, using arterial segments obtained from patients with known endothelial dysfunction.nLIPHOS provides a realistic, yet innovative and game-changing opportunity of reducing the impact of CVD in society and in the global economy, as well as providing huge market possibilities to the companies involved.

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