COOL-HRTEM

A double tilt cryoholder for ultra high resolution transmission electron microscopy at low temperatures

 Coordinatore TECHNISCHE UNIVERSITEIT DELFT 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 149˙953 €
 EC contributo 149˙953 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-PoC
 Funding Scheme CSA-SA(POC)
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-11-01   -   2013-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT

 Organization address address: Stevinweg 1
city: DELFT
postcode: 2628 CN

contact info
Titolo: Ms.
Nome: Jose
Cognome: Van Vugt
Email: send email
Telefono: +31 15 278 7413
Fax: +31 15 278 4301

NL (DELFT) hostInstitution 149˙953.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

aring    temperature    resolution    tilt    sub    tem    cryoholders    least    specimen       commercial    double    holders    images    plan   

 Obiettivo del progetto (Objective)

'The transmission electron microscope (TEM) is an essential instrument facilitating studies of the nanoscale material structure at sub-1Å resolution for R&D in the area of materials science, nanoscience and nanotechnology. In order to access the highly relevant temperature range between 77 K and room temperature, special specimen cryoholders need to be used that allow for a double tilt of the specimen under study. However, it is impossible to make images with sub-1Å resolution with the existing commercial double-tilt cryoholders. This is due to effects of thermal gradient-induced drift and mechanical vibrations. As part of my ERC Advanced Grant I have pioneered single-tilt cryoholders with electrical feedthroughs that largely overcome these problems, resulting in sub-1Å high resolution TEM at ~100 K in at least 15% of the images that are recorded. With this proposal, I wish to take these advances towards a proof of concept for a double-tilt cryoholder that allows sub-1Å high-resolution TEM in at least 80% of the recordings at any temperature between 77 K and 300 K and represents a user-friendly standard technique with commercial potential. I plan to make these holders available to researchers at similar price levels of currently available holders. Based on my acknowledged track record in developing microscopy innovations, I have drafted a plan to prototype this invention. I will seek an industrial partner to perform a design cycle for real production, and next produce the holders.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

DRUGE3CRLS (2013)

Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases

Read More  

SYNTHPHOTO (2014)

Powering cells with light: the synthetic biology of photosynthesis

Read More  

DALDECS (2010)

Development and Application of Laser Diagnostic Techniques for Combustion Studies

Read More