AIRSHIP

Acute Inflammation Resolution by Soluble Human Inhibitory Protein

Coordinatore	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Austria [AT]
Totale costo	150˙000 €
EC contributo	150˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-PoC
Funding Scheme	CSA-SA(POC)
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-12-01   -   2013-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH  Organization address address: Dr. Ignaz Seipel-Platz 2 city: WIEN postcode: 1010 contact info Titolo: Ms. Nome: Sigrid Cognome: Strodl Email: send email Telefono: +43 1 4016070028 Fax: +43 1 40160970000	AT (WIEN)	hostInstitution	150˙000.00

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 Obiettivo del progetto (Objective)

'Acute inflammatory processes are associated with infections as well as autoimmune flares at the basis of a variety of human diseases. While the molecular components and the logic of pro-inflammatory program are relatively well understood, less is known about the molecular mechanism of resolution, governing the termination of inflammatory responses. In the course of carrying out the i-FIVE ERC grant project plan, we identified a novel, secreted, soluble enzyme as a negative regulator of pro-inflammatory immunity receptors. Here we propose a defined and focused set of measures aimed at obtaining solid evidence for therapeutic feasibility of this novel biological agent in resolving inflammatory processes as well as for the securing of intellectual property. The AIRSHIP workplan proposes to obtain enough purified, soluble, endotoxin-free, active and glycosylated protein material to execute two critical tests, one monitoring the inflammatory response in human cells, and one addressing beneficiary effects in a lung murine infection model. Armed with such a successful proof of concept package and having strategically positioned and secured our intellectual property rights we would be determined to embark into an ambitious commercialization initiative.'