I-FIVE

Interferon-focused Innate Immunity Interactome and Inhibitome

Coordinatore	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Austria [AT]
Totale costo	1˙974˙022 €
EC contributo	1˙974˙022 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-AdG
Funding Scheme	ERC-AG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-04-01   -   2015-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH  Organization address address: Dr. Ignaz Seipel-Platz 2 city: WIEN postcode: 1010 contact info Titolo: Dr. Nome: Gerhard Cognome: Schadler Email: send email Telefono: 4314020000000 Fax: 43140200000000	AT (WIEN)	hostInstitution	1˙974˙022.40
2	CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH  Organization address address: Dr. Ignaz Seipel-Platz 2 city: WIEN postcode: 1010 contact info Titolo: Prof. Nome: Giulio Gino Maria Cognome: Superti Furga Email: send email Telefono: 436644000000 Fax: 43140200000000	AT (WIEN)	hostInstitution	1˙974˙022.40

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 Obiettivo del progetto (Objective)

'After a decade of development in model organisms and later in mammalian cells, mass spectrometry-based functional proteomics approaches have come of age and are ready to enable a systematic study of the innate immune system. We propose to cross the large-scale proteomics and innate immunity disciplines to obtain a functionally annotated map of the molecular machinery involved in viral recognition and leading to the hallmark interferon response, through a three-pronged approach: 1. Map the interactome of innate immunity proteins in macrophages to establish the network of components leading to interferon production; 2. Chart the interactions of molecular patterns, mostly nucleic acids, to identify the receptors and sensors at the non-self/self interface; 3. Study viral pathogenicity factors as molecular jammers of the anti-viral response and elucidate their mode of action to uncover critical nodes (inhibitome). Datasets are integrated and released at regular intervals with embargoed windows allowing a network of collaborators/own laboratory to do in-depth validation. New components at data intersections will be tested through loss-of-function experiments and standardized read-outs for the interferon pathway as well as genetic association with autoimmune diseases. Because of its unbiased/large scope and its cross-validating approaches, wherein the newly mapped circuitry is modeled, challenged by inducers and perturbed by viral agents, i-FIVE has the potential to promote a systems-level understanding of the interferon branch of molecular innate immunity. This insight may in turn create medical opportunities for the treatment of autoimmune disorders, septic shoc, arthritis as well as in boosting anti-viral responses.'

Introduzione (Teaser)

Shipping is essential for the health of Europe's economy, carrying millions of people and billions tonnes of goods from place to place every year. An EU-funded project hasensured that a greater portion of goods are transported by sea while the carbon footprint is reduced.

Descrizione progetto (Article)

Compared to other modes of transport, shipping has a clear advantage in terms of emissions per tonne nautical mile.

However, the amount of trade carried by sea is expected to rise over the coming years.

Green house gas emissions from shipping are thus likely to increase if ships are not designed with less resistance, cleaner engines and power production based on alternative fuels.In particular, the design of propellers has changed very little in the past years, although it affects the overall energy efficiency of the vessels.

To address these concerns, the 'Strategic research for innovative marine propulsion concepts' (http://www.streamline-project.eu/ (STREAMLINE)) has investigated three new, radically different propeller systems.The first relies on the installation of the propeller far behind the ships, so the size of the propeller can be increased dramatically while lowering its speed.

The second moves large amounts of water through relatively small changes in velocity, imitating the tail of a whale as it propels itself through water.

And the third comprises an array of small propellers, where water coming out of one set of propellers enhances the efficiency of the next set and so on.At the same time, the STREAMLINE team applied computational fluid dynamics tools and theoretical models to achieve higher levels of the efficiency for several currently used propellers.

They also searched for ways to boost the efficiency of water jet propulsion.

Despite the unparalleled performance at high speeds, a major drawback of waterjets is that for low speeds this propulsion system becomes inefficient as compared to conventional propellers.

Extensive tests in the laboratory have shown that power consumption for the new propeller systems can decrease by up to 13.5 %, while the overall efficiency gains can reach 30 %.

Once improvements verified in the laboratory move to the commercialisation phase, the STREAMLINE project will have a significant effect on reducing fuel consumption and polluting emissions in the not so distant future.