NAMIC
Nanowire Atomic Force Microscopy for Real Time Imaging of Nanoscale Biological Processes
| Coordinatore | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Switzerland [CH] |
| Totale costo | 1˙264˙640 € |
| EC contributo | 1˙264˙640 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2012-StG_20111012 |
| Funding Scheme | ERC-SG |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-12-01 - 2017-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | hostInstitution | 1˙264˙640.40 |
| 2 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | hostInstitution | 1˙264˙640.40 |
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Obiettivo del progetto (Objective)
'Short summary:
The ability to measure structures with nanoscale resolution continues to transform physics, materials science and life science alike. Nevertheless, while there are excellent tools to obtain detailed molecular-level static structure (for example in biology), there are very few tools to develop an understanding of how these structures change dynamically as they fulfill their biological function. New biologically-compatible, high-speed nanoscale characterization technologies are required to perform these measurements. In this project, we will develop a nanowire-based, high-speed atomic force microscope (NW-HS-AFM) capable of imaging the dynamics of molecular processes on living cells. We will use this instrument to study the dynamic pore-formation mechanisms of novel peptide antibiotics. This increase in performance over current AFMs will be achieved through the use of electron-beam-deposited nanogranular tunneling resistors on prefabricated nanowire AFM cantilevers. By combining these cantilevers with our state of the art high-speed AFM technology, we expect to obtain nanoscale-resolution images of protein pores on living cells at rates of tens of milliseconds per image. This capability will open a whole new arena for seeing nanoscale life in action.'