SARM

"Endometrial and embryonic genomics, searching for biomarkers in assisted reproduction (short title: Search for Assisted Reproduction Markers)"

 Coordinatore REPRODUKTIIVMEDITSIINI TAK AS 

 Organization address address: TIGI 61B
city: TARTU
postcode: 50410

contact info
Titolo: Prof.
Nome: Andres
Cognome: Salumets
Email: send email
Telefono: 3727330400

 Nazionalità Coordinatore Estonia [EE]
 Totale costo 2˙659˙068 €
 EC contributo 2˙659˙068 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IAPP
 Funding Scheme MC-IAPP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-01-01   -   2016-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    REPRODUKTIIVMEDITSIINI TAK AS

 Organization address address: TIGI 61B
city: TARTU
postcode: 50410

contact info
Titolo: Prof.
Nome: Andres
Cognome: Salumets
Email: send email
Telefono: 3727330400

EE (TARTU) coordinator 375˙149.97
2    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Dr.
Nome: Miles
Cognome: Davies
Email: send email
Telefono: 46852486593

SE (STOCKHOLM) participant 883˙234.50
3    IVIOMICS SL

 Organization address address: CL CATEDRATICO AGUSTIN ESCARDINO 9
city: PATERNA
postcode: 46980

contact info
Titolo: Mr.
Nome: Marcos
Cognome: Alepuz
Email: send email
Telefono: 34963905310
Fax: 34963902522

ES (PATERNA) participant 748˙637.40
4    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Monique
Cognome: Vanhaeren
Email: send email
Telefono: +32 16 32 9561
Fax: +32 16 32 6515

BE (LEUVEN) participant 510˙532.00
5    TARTU ULIKOOL

 Organization address address: ULIKOOLI 18
city: TARTU
postcode: 50090

contact info
Titolo: Prof.
Nome: Ants
Cognome: Kurg
Email: send email
Telefono: 3727375018

EE (TARTU) participant 141˙514.44

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

infertility    tartu    endometrial    reproduction    estonia    embryos    medical    sequencing    ivf    cell    medicine    treatment    human    embryo    sarm    single    improvements    pregnancy    reproductive    technological    rate   

 Obiettivo del progetto (Objective)

'Infertility is a serious medical concern preventing the parenthood in 10% of couples. Infertility treatment using assisted reproduction techniques (ART) is popular in Europe with up to 5% of children born thanks to medical help. Despite many technological improvements the overall pregnancy rate after infertility treatment using the most commonly practiced in vitro fertilization (IVF) remains only 30% per single cycle. The specific features of human reproduction include the high prevalence of diverse chromosomal pathologies in oocytes and early embryos, and significant dysregulation in gene expression in embryo and endometrial tissue, both being the risk factors for implantation failure and decreased pregnancy rate after IVF. Hence, the intrinsic motivation for the current SARM project stems from the perceived need to contribute to future IVF improvements and benefit from the recent breakthroughs in technological innovations. Our primary research objective is to unravel the molecular nature of human preimplantation embryo development and endometrial maturation. This ambitious goal will be achieved by exploiting highly sophisticated single-cell genomics tools, such as fine-resolution mapping of DNA copy-number changes by using SNP-arrays and sequencing platforms, and characterizing single-cell transcriptional landscape by RNA-sequencing. These studies are likely to propose novel embryonal and endometrial biomarkers useful for selecting the most competent embryos for transfer or identifying the causes of female infertility of endometrial origin. The SARM consortium consists of 2 industrial (IVIOMICS, Paterna/Spain and Competence Centre on Reproductive Medicine, Tartu/Estonia) and 3 academic (Karolinska Institute, Stockholm/Sweden; Katholieke Universiteit Leuven, Belgium and University of Tartu/Estonia) partners, forming a strong, stimulating and coherent research environment ensuring the pooling of complementary scientific skills in reproductive genetics and medicine.'

Altri progetti dello stesso programma (FP7-PEOPLE)

POLYQ MUTANT AR/SBMA (2013)

SBMA as a model of polyglutamine diseases: generation of a suitable cell system to study the post-transcriptional modifications of mutant androgen receptor and to discover potential therapeutic drugs

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ARTIFACTO (2009)

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HYPERBOLIC GRAPHS (2011)

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