FOLDHALO

Folding with Halogen Bonding

 Coordinatore POLITECNICO DI MILANO 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Italy [IT]
 Totale costo 1˙393˙000 €
 EC contributo 1˙393˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111012
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-03-01   -   2018-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    AALTO-KORKEAKOULUSAATIO

 Organization address address: OTAKAARI 1
city: ESPOO
postcode: 2150

contact info
Titolo: Prof.
Nome: Olli
Cognome: Ikkala
Email: send email
Telefono: +358 50 4100 454

FI (ESPOO) beneficiary 223˙968.00
2    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Sinikka
Cognome: Soirinsuo
Email: send email
Telefono: +358 20722 5010
Fax: +358 207227071

FI (ESPOO) beneficiary 40˙032.00
3    POLITECNICO DI MILANO

 Organization address address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133

contact info
Titolo: Dr.
Nome: Franca
Cognome: Di Censo
Email: send email
Telefono: 390224000000
Fax: 390224000000

IT (MILANO) hostInstitution 1˙129˙000.00
4    POLITECNICO DI MILANO

 Organization address address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133

contact info
Titolo: Prof.
Nome: Pierangelo
Cognome: Metrangolo
Email: send email
Telefono: 390224000000
Fax: 390224000000

IT (MILANO) hostInstitution 1˙129˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

sites    halogenated    bonding    recognition    chemistry    synthetic    molecules    biology    polyhalogenated    intermolecular    strand    organic    involving    halogen    pollutants    crystallographers    interactions    atoms   

 Obiettivo del progetto (Objective)

'The focus of this research project will be on halogen bonding, namely any noncovalent interactions involving halogen atoms as electrophilic species (electron density acceptor sites, Lewis acids, halogen bonding-donors). In particular, the overall goal of the project will be to fully elucidate the capabilities and properties of halogen atoms as recognition “sticky” sites in the context of biomolecules. The general objective of this research project will be achieved through the application of a multi-dimensional approach to the understanding of the intermolecular interactions involving halogenated molecules in chemistry and biology. The programme of work will centre around three closely integrated and synergistic strands. The common theme is to exploit halogen bonding for the design of “smart” peptides and foldamers (Strand 1), the obtainment of complexes of polyhalogenated organic pollutants with serum proteins (Strand 2), and to assemble biomimetic sensors for polyhalogenated organic pollutants (Strand 3). For the first time a multidisciplinary team composed by synthetic chemists, small molecule crystallographers, biologists, physicists, and protein crystallographers will join forces around the fundamental issues of: a) contributing to the establishment of the nature and properties of halogen bonding in ligand/biomolecule systems; b) improving our understanding of long-distance intermolecular interactions and their role on the energy profiles of biochemical transformations; c) facilitating preparation of more rationally designed new halogenated drugs; d) allowing for the mechanistic understanding of reactivity of halogen-containing molecules for the development of efficient and 'green' synthetic and bioremediation methods. The overall aim of this project is, therefore, to enlighten to the scientific community the potential that halogen bonding has to become a very powerful tool in the manipulation of molecular recognition phenomena in chemistry and biology.'

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Mathematical Methods for Financial Risk Management

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A-BINGOS (2014)

Accreting binary populations in Nearby Galaxies: Observations and Simulations

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GABACELLSANDMEMORY (2010)

Linking GABAergic neurones to hippocampal-entorhinal system functions

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