LINCMHEM

Role of DNA methylation in the regulation of lincRNAs in Hematological Malignancies

 Coordinatore FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA 

 Organization address address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008

contact info
Titolo: Ms.
Nome: Ana
Cognome: Iglesias Garcia
Email: send email
Telefono: 34948194700
Fax: 34948194718

 Nazionalità Coordinatore Spain [ES]
 Totale costo 352˙823 €
 EC contributo 352˙823 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-09-01   -   2016-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA

 Organization address address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008

contact info
Titolo: Ms.
Nome: Ana
Cognome: Iglesias Garcia
Email: send email
Telefono: 34948194700
Fax: 34948194718

ES (PAMPLONA) coordinator 352˙823.70

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

genes    dna    mechanism    affecting    genetic    methylation    intergenic    cancer    pathogenesis    lncrnas    rnas    coding    malignancies    lincrnas    play    alterations    ncrnas    human    expression    hematological    regulation    addition    genome   

 Obiettivo del progetto (Objective)

'Traditionally, cancer researchers have focused their best efforts on studying the genetic alterations affecting the coding genes. Subsequently, it was observed that in addition to genetic alterations, epigenetic alterations affecting coding genes play an important role in tumor development. In the last decade, largely due to the ability to sequence the human genome and the observation that much of the genome is transcribed but not translated, genes known as 'non-coding RNAs' (ncRNAs) have attracted great interest in relation to their biological functions and their role in human tumors. In addition to the small ncRNAs like miRNAs, is also revealing that the human genome also encodes numerous long non-coding RNAs (lncRNAs). Some of these lncRNAs are being found in the intergenic regions of the genome (long intergenic non-coding RNAs - lincRNAs). It is estimated that there may be more than 8000 lincRNAs in the human genome. The mechanism that regulates these lincRNAs and the functional mechanism of the vast majority of these lincRNAs are not known, but the few that have been studied are known to exert their function in the nucleus and to be involved in chromatin remodeling and transcription regulation. The expression of lincRNAs is altered in cancer, playing an important role in the initiation, prognosis and progression of human neoplasies. In this regard, preliminary results from our group show that DNA methylation may play an important role in the regulation of lincRNAs and probably in the pathogenesis of hematological malignancies. For all these reasons, the objectives of this “LincMHeM” proposal are to determine whether inappropriate DNA methylation is involved in regulating lincRNA expression, and if such deregulated lincRNAs are involved in pathogenesis and are potential therapeutic targets for treating B cell hematological malignancies (multiple myeloma, lymphoma and acute lymphoblastic leukemia).'

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