NEURO-COMM

Inter-areal cortical communication: investigating the relationship between hemodynamic and electrophysiological measurements

 Coordinatore EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH 

 Organization address address: Raemistrasse 101
city: ZUERICH
postcode: 8092

contact info
Titolo: Prof.
Nome: Nicole
Cognome: Wenderoth
Email: send email
Telefono: +41 44 635 61 57

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-06-01   -   2017-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH

 Organization address address: Raemistrasse 101
city: ZUERICH
postcode: 8092

contact info
Titolo: Prof.
Nome: Nicole
Cognome: Wenderoth
Email: send email
Telefono: +41 44 635 61 57

CH (ZUERICH) coordinator 100˙000.00

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fmri    magnetic    hemodynamic    slow    temporal    brain    cortical    functional    eeg    fast    spatial    interactions    networks    fluctuations    oscillations    electrophysiological    measured    areal    invasively    scales    communication    inter   

 Obiettivo del progetto (Objective)

'Perception, cognition and behaviour are achieved through the coordination of multiple brain regions, which exchange information between each other. Large-scale functional interactions arise at two distinct but potentially related temporal scales: “slow” hemodynamic fluctuations measured with functional magnetic resonance imaging (fMRI); and “fast” electrophysiological oscillations of the neurons, as measured non-invasively by electroencephalography (EEG) and magnetoencephalography, and invasively at finer spatial scales by local field potentials and multi-unit activity. Despite enormous recent progress, our understanding of the relationship between, and functional role of fast and slow synchronization in inter-areal cortical communication is still limited. In this project, we will study interactions in large-scale functional networks of healthy human volunteers using combined electrophysiological and hemodynamic measures. We will characterize functional brain networks showing coherent hemodynamic activity at rest and examine how the functional architecture of these networks varies with active behaviour. Moreover, we will study large-scale interactions at different spatio-temporal scales, relating slow fMRI fluctuations with fast EEG oscillations recorded simultaneously. Finally, we will target specific areas under different states by transcranial magnetic stimulation to investigate the causal effects of these focal perturbations on the spatial and temporal properties of brain networks. These studies will provide deeper insights into the mechanisms underlying inter-areal cortical communication and their functional role with respect to behaviour.'

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