DIAGMAL

Translation of the direct-on-blood PCR-NALFIA system into an innovative near point-of-care diagnostic for malaria

 Coordinatore HET KONINKLIJK INSTITUUT VOOR DE TROPEN 

 Organization address address: "Mauritskade, 63"
city: AMSTERDAM
postcode: 1092 AD

contact info
Titolo: Dr.
Nome: Hendricus
Cognome: Schallig
Email: send email
Telefono: +31 205665447
Fax: +31 206971841

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 3˙555˙961 €
 EC contributo 2˙652˙374 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-2
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-09-01   -   2016-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    HET KONINKLIJK INSTITUUT VOOR DE TROPEN

 Organization address address: "Mauritskade, 63"
city: AMSTERDAM
postcode: 1092 AD

contact info
Titolo: Dr.
Nome: Hendricus
Cognome: Schallig
Email: send email
Telefono: +31 205665447
Fax: +31 206971841

NL (AMSTERDAM) coordinator 942˙320.00
2    Q-BIOANALYTIC GMBH

 Organization address address: FISCHKAI 1
city: BREMERHAVEN
postcode: 27572

contact info
Titolo: Dr.
Nome: Boris
Cognome: Oberheitmann
Email: send email
Telefono: +49 4714832442

DE (BREMERHAVEN) participant 677˙080.00
3    FORSITE DIAGNOSTICS LTD

 Organization address address: BLOCK 21, Sand Hutton
city: YORK
postcode: YO41 1LZ

contact info
Titolo: Dr.
Nome: Paul
Cognome: Meakin
Email: send email
Telefono: +44 1904462462

UK (YORK) participant 534˙274.00
4    GLOBAL INNOVATION NETWORK OY

 Organization address address: Automaatiotie 1
city: OULUNSALO
postcode: 90460

contact info
Titolo: Mrs.
Nome: Sinikka
Cognome: Fabritius
Email: send email
Telefono: +358 407785642

FI (OULUNSALO) participant 498˙700.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

malaria    read    blood    treatment    mdx    successful    simple    pcr    direct    diagnostic    limitations    tests    contamination    risk   

 Obiettivo del progetto (Objective)

'Accurate diagnosis of malaria is essential to timely install proper treatment. Current diagnostic methods for malaria have limitations, such as detection limit and problems with antigen persistence after successful treatment (rapid diagnostic tests) or may require technical expertise and equipment (microscopy). Treatment on the basis of clinical symptoms only (fever = malaria) must be abandoned. Molecular diagnostic tests (MDx) could circumvent some of the mentioned limitations, but tests are incompatable with the Point of Care concept as they require sample processing, have a contamination risk and complicated read-out systems. Although Real-Time PCR assays have overcome some of these problems, the need of large and expensive equipment and the inability to perform it directly on blood shows the need to further improvement and simplification of MDx. Building on the successful outcomes of EU FP7 project “MALACTRES”, the current proposal aims to further built on the concept of a direct on blood PCR system combined with a simple read-out system. This concept has the following advantages: - Direct on blood: no DNA extraction or sample processing; - Simple read-out system (black/white), no need for gel electrophoresis or computer. The proof of concept was delivered in laboratory ring trials and field evaluations in Thailand and Burkina Faso. The proposed diagnostic will have the following additional features: - Direct on blood and simple read-out - Closed system: reduced risk of contamination - Stabilizing reagents included: increased shelf life, no cold storage - Cheap, quick, sensitive and specific. It is envisaged that a full marketable product will be available in 36 months. During development the consortium (dominated by SMEs) will also look into possibilities to adapt the developed system to small hand-held PCR devices preferably in combination with solar-power operated or chargeable batteries that further enhances the application of the test in remote settings.'

Altri progetti dello stesso programma (FP7-HEALTH)

EUROVISIONNET (2008)

Visual Impairment and Degeneration: A Road-map for Vision Research within Europe

Read More  

SETTREND (2010)

"Schistosoma Epigenetics - Targets, Regulation, New Drugs"

Read More  

CHERISH (2009)

"Improving Diagnoses of Mental Retardation in Children in Central Eastern Europe and Central Asia through Genetic Characterisation and Bioinformatics/-Statistics,"

Read More