NEUROMICS

Exploring the changing genomic landscape during neural fate acquisition in Drosophila

Coordinatore	FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS    more  Organization address address: N PLASTIRA STR 100 city: HERAKLION postcode: 70013 contact info Titolo: Ms. Nome: Zinovia Cognome: Papatheodorou Email: send email Telefono: +30 2810 391522 Fax: +30 2810 391555
Nazionalità Coordinatore	Greece [EL]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-08-01   -   2017-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS  Organization address address: N PLASTIRA STR 100 city: HERAKLION postcode: 70013 contact info Titolo: Ms. Nome: Zinovia Cognome: Papatheodorou Email: send email Telefono: +30 2810 391522 Fax: +30 2810 391555	EL (HERAKLION)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Western societies are faced with a variety of human conditions of neurological nature spanning from cancer to psychological disorders. In biomedical research Drosophila has been used extensively as a genetic model organism to study development and disease related phenotypes. Many key molecules that participate in the development of the nervous system are conserved from fly to human. Here, I propose to combine the powerful Drosophila genetics with the novel deep-sequencing assays to reveal what determines the neural stem cell (neuroblast) fate in the developing embryo. In particular, I propose to map the genome binding events of co-operating key gene regulatory transcription factors specifically in the early neuroectoderm from which nascent neuroblasts will arise. I will also document the chromatin structure and gene expression profiles in these two distinct tissues, neuroectoderm and neuroblasts. This systems biology approach will reveal what determines neural stem cell biogenesis at the global genomic level, which remains to date unexplored. Drosophila is ideal for this approach, as it affords sophisticated transgenesis tools for the targeting of bait molecules to specific tissues and developmental stages. In addition, I aim to integrate our Drosophila data with available expression data form human neural tissue diseases in order to discover potential novel candidates relevant for human disease by cross-species bioinformatics. The successful completion of this proposal will be the cornerstone in my career development path establishing me as a competitive independent researcher in the field of transcriptional regulation of complex multicellular systems.'